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Gene Review: 

ninaB  -  neither inactivation nor afterpotential B

Drosophila melanogaster

Synonyms: CG9347, DRPE65, Dmel\CG9347, RPE65, anon-WO0148162.1, ...
 
 
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Disease relevance of ninaB

 

High impact information on ninaB

  • Analysis of the blind Drosophila mutant ninaB identifies the gene encoding the key enzyme for vitamin A formation invivo [2].
  • The Drosophila ninaB gene encodes a beta,beta-carotene-15,15'-oxygenase responsible for the centric cleavage of beta-carotene that produces the retinal chromophore of rhodopsin [3].
 

Biological context of ninaB

References

  1. Filling the gap in vitamin A research. Molecular identification of an enzyme cleaving beta-carotene to retinal. von Lintig, J., Vogt, K. J. Biol. Chem. (2000) [Pubmed]
  2. Analysis of the blind Drosophila mutant ninaB identifies the gene encoding the key enzyme for vitamin A formation invivo. von Lintig , J., Dreher, A., Kiefer, C., Wernet, M.F., Vogt, K. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  3. Drosophila ninaB and ninaD act outside of retina to produce rhodopsin chromophore. Gu, G., Yang, J., Mitchell, K.A., O'Tousa, J.E. J. Biol. Chem. (2004) [Pubmed]
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