Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

foxo - forkhead box, sub-group O

Drosophila melanogaster

Kramer, J.M., Luo, X., Fuss, B., Giannakou, M.E., Liu, Y., et al.

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Disease relevance of foxo

In step mutant animals both cell size and cell number are reduced, resulting in decreased body size and body weight in larvae, pupae and adults. step acts upstream of PI(3)K and is required for the proper regulation of Akt and the transcription factor FOXO [1].

High impact information on foxo

Here we show that JNK requires Foxo to extend life span in Drosophila [2].
Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway [3].
These data suggest that integrating stress and survival signals through Foxo drives the decision between cell death and repair of damaged cells in vivo [4].
Our results indicate that UV-induced apoptosis is repressed by receptor tyrosine kinase-mediated inactivation of Foxo [4].
Akt and foxo Dysregulation Contribute to Infection-Induced Wasting in Drosophila [5].

Biological context of foxo

The role of FOXO transcription factors and the adipose tissue are therefore evolutionarily conserved in the regulation of aging, and reduction of IIS in the adult is sufficient to mediate its effects on life-span and fecundity [6].
This phenotype can be rescued by co-expression of upstream insulin signaling components, dPI3K and dAkt, however, this rescue is not seen when FOXO is mutated to a constitutively active form [7].
RESULTS: We have identified the Drosophila melanogaster homologue of FOXO (dFOXO), which is conserved in amino acid sequence compared with the mammalian FOXO homologues and Daf-16 [7].

Anatomical context of foxo

We further show that Drosophila FOXO is not required for normal salivary gland death and that the rescue of salivary gland death by PI3K occurs independent of FOXO [8].

Other interactions of foxo

The FOXO (forkhead box, sub-group "O") transcription factors regulate cellular processes under conditions of low levels of insulin signaling [7].

Analytical, diagnostic and therapeutic context of foxo

Studies in mammalian cell culture show that activation of FOXO transcription factors causes cell death or cell cycle arrest [7].

References

The cytohesin Steppke is essential for insulin signalling in Drosophila. Fuss, B., Becker, T., Zinke, I., Hoch, M. Nature (2006)
JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Wang, M.C., Bohmann, D., Jasper, H. Cell (2005)
Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Puig, O., Marr, M.T., Ruhf, M.L., Tjian, R. Genes Dev. (2003)
Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation. Luo, X., Puig, O., Hyun, J., Bohmann, D., Jasper, H. EMBO J. (2007)
Akt and foxo Dysregulation Contribute to Infection-Induced Wasting in Drosophila. Dionne, M.S., Pham, L.N., Shirasu-Hiza, M., Schneider, D.S. Curr. Biol. (2006)
Long-lived Drosophila with overexpressed dFOXO in adult fat body. Giannakou, M.E., Goss, M., Jünger, M.A., Hafen, E., Leevers, S.J., Partridge, L. Science (2004)
Expression of Drosophila FOXO regulates growth and can phenocopy starvation. Kramer, J.M., Davidge, J.T., Lockyer, J.M., Staveley, B.E. BMC Dev. Biol. (2003)
FOXO-independent suppression of programmed cell death by the PI3K/Akt signaling pathway in Drosophila. Liu, Y., Lehmann, M. Dev. Genes Evol. (2006)