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Gene Review

MEIS2  -  Meis homeobox 2

Homo sapiens

Synonyms: Homeobox protein Meis2, HsT18361, MRG1, Meis1-related protein 1
 
 
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Disease relevance of MEIS2

 

High impact information on MEIS2

  • Surprisingly, Vp16-Meis1 (but not engrailed-Meis1) functioned as an autonomous oncoprotein that mimicked combined activities of Meis1 plus Hoxa9, immortalizing early progenitors, inducing low-level expression of Meis1-related signature genes, and causing leukemia without coexpression of exogenous or endogenous Hox genes [2].
  • Strikingly, expression of Hoxa9 or Hoxa7 stimulated both leukemic aggressiveness and transcription of Meis1-related signature genes in Vp16-Meis1 progenitors [2].
  • In acinar cell lines the activity is mediated by a complex comprising PDX1, PBX1b, and MRG1 (MEIS2) [3].
  • Identification of a conserved family of Meis1-related homeobox genes [4].
  • We report the sequence of Mrg1 and MRG2 as well as their chromosomal locations in murine and human genomes [4].
 

Biological context of MEIS2

 

Anatomical context of MEIS2

  • In addition, MEIS2 and PREP1 exhibited expression in the mid-to upper hair cortex, with PREP1 being also expressed in the dermal papilla and the connective tissue sheath of the hair follicle [7].
  • Moreover, immunoblot analysis using mutant animals with germline deficiencies indicated that MRG-1 is synthesized predominantly in oocytes [8].
  • As development proceeds, meis2 is also expressed in the developing retina, pharyngeal arches, and in the vicinity of the gut tube [6].
  • MRG-1, a mortality factor-related chromodomain protein, is required maternally for primordial germ cells to initiate mitotic proliferation in C. elegans [8].
 

Associations of MEIS2 with chemical compounds

 

Other interactions of MEIS2

  • Only the N-terminal region of MEIS2, including the conserved MEIS domains, is required for formation of a trimer on DNA and transcriptional activity: the MEIS homeodomain is dispensable [10].

References

  1. The role of the MEIS homeobox genes in neuroblastoma. Geerts, D., Schilderink, N., Jorritsma, G., Versteeg, R. Cancer Lett. (2003) [Pubmed]
  2. Persistent transactivation by meis1 replaces hox function in myeloid leukemogenesis models: evidence for co-occupancy of meis1-pbx and hox-pbx complexes on promoters of leukemia-associated genes. Wang, G.G., Pasillas, M.P., Kamps, M.P. Mol. Cell. Biol. (2006) [Pubmed]
  3. An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2). Swift, G.H., Liu, Y., Rose, S.D., Bischof, L.J., Steelman, S., Buchberg, A.M., Wright, C.V., MacDonald, R.J. Mol. Cell. Biol. (1998) [Pubmed]
  4. Identification of a conserved family of Meis1-related homeobox genes. Steelman, S., Moskow, J.J., Muzynski, K., North, C., Druck, T., Montgomery, J.C., Huebner, K., Daar, I.O., Buchberg, A.M. Genome Res. (1997) [Pubmed]
  5. Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene. Smith, J.E., Afonja, O., Yee, H.T., Inghirami, G., Takeshita, K. Mamm. Genome (1997) [Pubmed]
  6. Cloning and expression of the TALE superclass homeobox Meis2 gene during zebrafish embryonic development. Biemar, F., Devos, N., Martial, J.A., Driever, W., Peers, B. Mech. Dev. (2001) [Pubmed]
  7. The HOXC13-controlled expression of early hair keratin genes in the human hair follicle does not involve TALE proteins MEIS and PREP as cofactors. Jave-Suárez, L.F., Schweizer, J. Arch. Dermatol. Res. (2006) [Pubmed]
  8. MRG-1, a mortality factor-related chromodomain protein, is required maternally for primordial germ cells to initiate mitotic proliferation in C. elegans. Fujita, M., Takasaki, T., Nakajima, N., Kawano, T., Shimura, Y., Sakamoto, H. Mech. Dev. (2002) [Pubmed]
  9. Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes. Mercader, N., Leonardo, E., Piedra, M.E., Martínez-A, C., Ros, M.A., Torres, M. Development (2000) [Pubmed]
  10. DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex. Liu, Y., MacDonald, R.J., Swift, G.H. J. Biol. Chem. (2001) [Pubmed]
 
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