High impact information on HOXB5

• Conversely, the 3' HoxB genes (Hoxb1 and Hoxb3-Hoxb5) are sensitive to RA but not FGF treatments at these stages [1].
• Dorsal root ganglia and the lung rudiment also contain Ghox 2.1 message, but in somewhat lower amounts [2].
• Mid- and forebrain, the heart, presomitic mesenchyme and notochord do not contain detectable levels of Ghox 2.1 mRNA [2].
• In situ hybridization with 35S-labelled antisense riboprobes derived from Ghox 2.1 demonstrates that this gene is expressed at high levels in spinal chord, myelencephalon and mesonephros [2].
• Of particular interest is the expression of Ghox 2.1 in a well-defined patch of mesenchymal tissue situated in an anterioproximal region of the limb bud [2].

Anatomical context of HOXB5

• Hoxb-5 and Hoxb-6 expression domains demarcate the trachea, bronchial tree, and air sacs [3].
• We analyzed the spatial expression patterns of Hox genes belonging to the HoxA and HoxB cluster (Hoxa-4 approximately a-9, Hoxb-5 approximately b-9) in the developing chick digestive tract [4].

References