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Gene: BG4  -  BG4

Drosophila melanogaster

Synonyms: CG12297, Death domain-containing adapter protein BG4, dFADD, FADD
 
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Disease relevance of BG4

  • Our data show that loss of dFADD function renders flies highly susceptible to Gram-negative infections without affecting resistance to Gram-positive bacteria [1].
  • Using inducible expression of dFADD double-stranded RNA, we demonstrate that dFADD is a novel component of the Imd pathway: dFADD double-stranded RNA expression reduces the induction of antibacterial peptide-encoding genes after infection and renders the fly susceptible to Gram-negative bacterial infection [2].
 

High impact information on BG4

  • Using a two-hybrid screen in yeast, we have isolated the death protein dFADD as a molecule that associates with IMD [1].
  • We also show that dMyD88 associates with the death domain-containing adapter Drosophila Fas-associated death domain-containing protein (dFADD), which in turn interacts with the apical caspase Dredd [3].
  • Characterization of reaper- and FADD-induced apoptosis in a lepidopteran cell line [4].
  • Epistatic studies indicate that dFADD acts between Imd and Dredd [2].
  • dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD [5].
 

Biological context of BG4

  • The structural and functional similarities between dFADD and FADD suggest the existence of a FADD-like apoptosis pathway in Drosophila [5].

References

  1. The Drosophila immune defense against gram-negative infection requires the death protein dFADD. Naitza, S., Rossé, C., Kappler, C., Georgel, P., Belvin, M., Gubb, D., Camonis, J., Hoffmann, J.A., Reichhart, J.M. Immunity (2002)
  2. Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults. Leulier, F., Vidal, S., Saigo, K., Ueda, R., Lemaitre, B. Curr. Biol. (2002)
  3. Drosophila MyD88 is an adapter in the Toll signaling pathway. Horng, T., Medzhitov, R. Proc. Natl. Acad. Sci. U.S.A. (2001)
  4. Characterization of reaper- and FADD-induced apoptosis in a lepidopteran cell line. Vucic, D., Seshagiri, S., Miller, L.K. Mol. Cell. Biol. (1997)
  5. dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD. Hu, S., Yang, X. J. Biol. Chem. (2000)
 
 
 
 
 
 
 
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