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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review: 

GPHN  -  gephyrin

Gallus gallus

Synonyms: Gephyrin
 
 
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High impact information on GPHN

  • Our results show that the first aggregates of the GABA(A) receptor, the glycine receptor, and gephyrin appear in the inner plexiform layer after 8 days in culture simultaneously with the development of the first active zones and postsynaptic densities [1].
  • These results reveal different patterns of development for the investigated pre- and postsynaptic proteins and indicate a parallel appearance of gephyrin, glycine receptor, and the beta 2 and beta 3-subunits of the GABAA receptor with the first synaptic specializations in the inner plexiform layer of the developing chick retina [2].
  • Six monoclonal antibodies, directed against glycine and gamma-aminobutyric acid (GABA)A receptor subunits, the intracellular receptor-associated protein gephyrin, synaptotagmin, and synaptophysin were used to determine the initial appearance and distribution of their antigens [2].
 

Analytical, diagnostic and therapeutic context of GPHN

References

  1. Synapse formation and agrin expression in stratospheroid cultures from embryonic chick retina. Hering, H., Kröger, S. Dev. Biol. (1999) [Pubmed]
  2. Formation of synaptic specializations in the inner plexiform layer of the developing chick retina. Hering, H., Kröger, S. J. Comp. Neurol. (1996) [Pubmed]
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