Gene Review:
MN1 - meningioma (disrupted in balanced...
Homo sapiens
Synonyms:
MGCR, MGCR1, MGCR1-PEN, dJ353E16.2
- MN1-TEL, the product of the t(12;22) in human myeloid leukemia, immortalizes murine myeloid cells and causes myeloid malignancy in mice. Carella, C., Bonten, J., Rehg, J., Grosveld, G.C. Leukemia (2006)
- Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma. Lekanne Deprez, R.H., Riegman, P.H., Groen, N.A., Warringa, U.L., van Biezen, N.A., Molijn, A.C., Bootsma, D., de Jong, P.J., Menon, A.G., Kley, N.A. Oncogene (1995)
- Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. Buijs, A., Sherr, S., van Baal, S., van Bezouw, S., van der Plas, D., Geurts van Kessel, A., Riegman, P., Lekanne Deprez, R., Zwarthoff, E., Hagemeijer, A. Oncogene (1995)
- TEL and MN1 fusion in myelodysplastic syndrome: new evidence for a therapy-related event. Vieira, L., Marques, B., Ambrósio, A.P., Chumbo, M., Reis, A.B., Júnior, E.C., Boavida, M.G. Br. J. Haematol. (2000)
- Drug resistance associated with loss of p53 involves extensive alterations in microtubule composition and dynamics. Galmarini, C.M., Kamath, K., Vanier-Viornery, A., Hervieu, V., Peiller, E., Falette, N., Puisieux, A., Ann Jordan, M., Dumontet, C. Br. J. Cancer (2003)
- Genetic mapping of a second myotonic dystrophy locus. Ranum, L.P., Rasmussen, P.F., Benzow, K.A., Koob, M.D., Day, J.W. Nat. Genet. (1998)
- High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics. Heuser, M., Beutel, G., Krauter, J., D??hner, K., von Neuhoff, N., Schlegelberger, B., Ganser, A. Blood (2006)
- Conditional MN1-TEL knock-in mice develop acute myeloid leukemia in conjunction with overexpression of HOXA9. Kawagoe, H., Grosveld, G.C. Blood (2005)
- Labd-14-ene-8,13-diol (sclareol) induces cell cycle arrest and apoptosis in human breast cancer cells and enhances the activity of anticancer drugs. Dimas, K., Papadaki, M., Tsimplouli, C., Hatziantoniou, S., Alevizopoulos, K., Pantazis, P., Demetzos, C. Biomed. Pharmacother. (2006)
- The 1,25(OH)2D3-regulated transcription factor MN1 stimulates vitamin D receptor-mediated transcription and inhibits osteoblastic cell proliferation. Sutton, A.L., Zhang, X., Ellison, T.I., Macdonald, P.N. Mol. Endocrinol. (2005)
- The MN1-TEL fusion protein, encoded by the translocation (12;22)(p13;q11) in myeloid leukemia, is a transcription factor with transforming activity. Buijs, A., van Rompaey, L., Molijn, A.C., Davis, J.N., Vertegaal, A.C., Potter, M.D., Adams, C., van Baal, S., Zwarthoff, E.C., Roussel, M.F., Grosveld, G.C. Mol. Cell. Biol. (2000)
- The MN1 oncoprotein activates transcription of the IGFBP5 promoter through a CACCC-rich consensus sequence. Meester-Smoor, M.A., Molijn, A.C., Zhao, Y., Groen, N.A., Groffen, C.A., Boogaard, M., van Dalsum-Verbiest, D., Grosveld, G.C., Zwarthoff, E.C. J. Mol. Endocrinol. (2007)
- MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML. Heuser, M., Argiropoulos, B., Kuchenbauer, F., Yung, E., Piper, J., Fung, S., Schlenk, R.F., Dohner, K., Hinrichsen, T., Rudolph, C., Schambach, A., Baum, C., Schlegelberger, B., Dohner, H., Ganser, A., Humphries, R.K. Blood (2007)
- Influence of new molecular prognostic markers in patients with karyotypically normal acute myeloid leukemia: recent advances. Mrózek, K., Döhner, H., Bloomfield, C.D. Curr. Opin. Hematol. (2007)
- Long-range sequence composition mirrors linkage disequilibrium pattern in a 1.13 Mb region of human chromosome 22. Eisenbarth, I., Striebel, A.M., Moschgath, E., Vogel, W., Assum, G. Hum. Mol. Genet. (2001)
- Analysis of TEL proteins in human leukemias. Poirel, H., Lacronique, V., Mauchauffé, M., Le Coniat, M., Raffoux, E., Daniel, M.T., Erickson, P., Drabkin, H., MacLeod, R.A., Drexler, H.G., Ghysdael, J., Berger, R., Bernard, O.A. Oncogene (1998)
- Recovery of anal sphincter function after the ileoanal reservoir procedure in patients over the age of fifty. Jorge, J.M., Wexner, S.D., James, K., Nogueras, J.J., Jagelman, D.G. Dis. Colon Rectum (1994)