High impact information on Axn

• Here the Drosophila protein D-Axin was shown to interact with Armadillo and D-APC [1].
• Hence, D-Axin negatively regulates Wingless signaling by down-regulating the level of Armadillo [1].
• Armadillo nuclear import is regulated by cytoplasmic anchor Axin and nuclear anchor dTCF/Pan [2].
• A role of Dishevelled in relocating Axin to the plasma membrane during wingless signaling [3].
• We determined that WRM-1 and the major canonical Wnt pathway components: BAR-1, SGG-1/GSK-3 and PRY-1/Axin were not involved in the control of B cell polarity [4].

Biological context of Axn

• We also show that the level of Sgg(Zw3) activity regulates the stability of Armadillo protein and modulates the level of phosphorylation of D-Axin and Armadillo [5].

Anatomical context of Axn

• Here, we show that Wingless signaling causes a striking relocation of Drosophila Axin from the cytoplasm to the plasma membrane [3].

Associations of Axn with chemical compounds

• In a yeast two-hybrid screen using the Drosophila Axin protein as a bait, we have identified a Drosophila homolog of CAP, a component of the glucose transport regulatory complex [6].

Physical interactions of Axn

• It may permit the subsequent inactivation of the Axin complex by Wingless signaling [3].

Enzymatic interactions of Axn

• In the absence of Wnt ligand, beta-catenin is phosphorylated by the Axin complex, which earmarks it for rapid degradation by the ubiquitin system [3].

Other interactions of Axn

• Our results provide evidence for a function of Axin in the regulation of Armadillo that is different from its role as a scaffold for GSK3beta [7].
• We propose that Arrow (LRP) recruits Axin to the membrane, and that this interaction leads to Axin degradation [8].

References