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Gene Review: 

janA  -  janus A

Drosophila melanogaster

Synonyms: BcDNA:AT12574, CG7933, Dmel\CG7933, jan, Jan, ...
 
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Disease relevance of janA

  • Although the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway is part of the antiviral response in arthropods such as Drosophila, here we show that white spot syndrome virus (WSSV) uses a shrimp STAT as a transcription factor to enhance viral gene expression in host cells [1].
 

High impact information on janA

  • We report here that RacGAP50C corresponds to the tumbleweed (tum) gene previously identified based on its defects in dendrite development of sensory neurons [Gao, F. B., Brenman, J. E., Jan, L. Y. & Jan, Y. N. (1999) Genes Dev. 13, 2549-2561] [2].
  • The 5' end of the janB mRNA mapped within the 3' untranslated region of the janA transcribed sequence [3].
  • The two genes also share homology with the adjacent janusA (janA) gene, suggesting that multiple duplication events have occurred within this region of the genome [4].
  • In order to test the possibility that some cis-acting regulatory sequences are shared by the two genes, we carried out a deletion analysis of the jan A/sry beta intergenic region in D. melanogaster using transgenic lacZ fusion genes [5].
  • Sequence comparison of the jan A-sry beta intergenic region and 5'-transcribed domain of each gene between D. melanogaster and D. pseudoobscura reveals short stretches of conserved sequences that may correspond to cis-acting regulator elements [5].
 

Biological context of janA

  • A restriction survey of an additional 28 lines of D. simulans revealed strong linkage disequilibrium over the janA-janB region and identified six more alleles matching the rare haplotype [6].
  • Data obtained from genomic and cDNA sequencing and from a combination of S1 mapping and primer extension experiments indicated a very unusual organization of this locus, which appeared to be composed of two partially overlapping genes, designated janA and janB [3].
  • Results showed that the testis-specific expression of the janB gene is mediated by a short DNA sequence (positions -174 to +107) which is located entirely within the last exon of the upstream janA gene [7].
 

Other interactions of janA

  • Our results show that sry beta cis-acting sequences are located in the (-117; +137) 5'-region of the gene and that jan A cis-regulatory sequences are included in the (-56; +151) 5'-domain of this gene [5].

References

  1. White spot syndrome virus annexes a shrimp STAT to enhance expression of the immediate-early gene ie1. Liu, W.J., Chang, Y.S., Wang, A.H., Kou, G.H., Lo, C.F. J. Virol. (2007)
  2. Function and regulation of Tumbleweed (RacGAP50C) in neuroblast proliferation and neuronal morphogenesis. Goldstein, A.Y., Jan, Y.N., Luo, L. Proc. Natl. Acad. Sci. U.S.A. (2005)
  3. Transcriptional and posttranscriptional regulation contributes to the sex-regulated expression of two sequence-related genes at the janus locus of Drosophila melanogaster. Yanicostas, C., Vincent, A., Lepesant, J.A. Mol. Cell. Biol. (1989)
  4. Molecular evolution of the ocnus and janus genes in the Drosophila melanogaster species subgroup. Parsch, J., Meiklejohn, C.D., Hauschteck-Jungen, E., Hunziker, P., Hartl, D.L. Mol. Biol. Evol. (2001)
  5. Separate cis-regulatory sequences control expression of serendipity beta and janus A, two immediately adjacent Drosophila genes. Yanicostas, C., Ferrer, P., Vincent, A., Lepesant, J.A. Mol. Gen. Genet. (1995)
  6. Patterns of DNA sequence variation suggest the recent action of positive selection in the janus-ocnus region of Drosophila simulans. Parsch, J., Meiklejohn, C.D., Hartl, D.L. Genetics (2001)
  7. Transcriptional and translational cis-regulatory sequences of the spermatocyte-specific Drosophila janusB gene are located in the 3' exonic region of the overlapping janusA gene. Yanicostas, C., Lepesant, J.A. Mol. Gen. Genet. (1990)
 

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Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt

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