High impact information on chp

• These data are consistent with the proposal that chaoptin is involved in the adhesion between photoreceptor cell membranes [1].
• Chaoptin, a cell surface glycoprotein required for Drosophila photoreceptor cell morphogenesis, contains a repeat motif found in yeast and human [1].
• Chaoptin synthesized in vitro is associated with rough endoplasmic reticulum microsomal membrane in an integral fashion, consistent with its extraction characteristics in vivo [1].
• In accordance with the mutant phenotype, we have renamed this genetic locus chaoptic and the encoded glycoprotein, chaoptin [2].
• This localization and the morphological abnormalities in mutants support the hypothesis that chaoptin may mediate adhesion between closely apposed membranes [2].

Biological context of chp

• On the basis of biochemical and genetic analyses we previously proposed that chaoptin might function as a cell adhesion molecule [3].
• The pil chp genes appear to control the expression of additional virulence factors, however, since the wild-type fly-killing phenotype of a subset of mutants isolated on the basis of their compact colony morphology indicated that twitching motility itself was not required for full virulence in the fly [4].
• Neural-specific and lethal-specific mutations map to unique exons, while neural-lethal mutations map to shared exons [5].

Anatomical context of chp

• The chaoptic gene is expressed exclusively in photoreceptor neurons, and mutations of the gene result in reduced developmental competence of cells to generate normal rhabdomeric membranes [6].
• Immunoelectron microscopy indicates that chaoptin is distributed along the length of the microvillus [2].

Associations of chp with chemical compounds

• Drosophila chaoptin, a member of the leucine-rich repeat family, is a photoreceptor cell-specific adhesion molecule [3].
• Immunoreactivity to 22C10, a marker of an early neuronal antigen, as well as to the photoreceptor-specific antibody 24B10, suggests that differentiation of neuronal and photoreceptor antigens does not require 20-hydroxyecdysone [7].

Other interactions of chp

• In contrast, the distribution of the opsin transcript was not affected by the chaoptic mutation [6].
• Neural-specific overexpression of drosophila plenty of SH3s (DPOSH) extends the longevity of adult flies [8].

References