Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

plexB - plexin B

Drosophila melanogaster

Synonyms: CG17245, Dmel\CG17245, PLEXB, PlexB, Plexin-B, ...

Hu, H. et al., Ayoob, J.C. et al., Winberg, M.L. et al.

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High impact information on plexB

In the immune system, VESPR, a member of the Plexin family, is a receptor for a viral-encoded Semaphorin [1].
A different region of PlexB binds to RhoA [2].
Here, we define a seven amino acid sequence in PlexB required for Rac(GTP) binding [2].
Here, we show that plexB, like plexA, is robustly expressed in the developing CNS and is required for motor and CNS axon pathfinding [3].
Drosophila Plexin B is a Sema-2a receptor required for axon guidance [3].

Other interactions of plexB

These results suggest a model whereby PlexB mediates repulsion by coordinately regulating two small GTPases in opposite directions: PlexB binds to Rac(GTP) and downregulates its output by blocking its access to PAK and, at the same time, binds to and increases the output of RhoA [2].

References

Plexin A is a neuronal semaphorin receptor that controls axon guidance. Winberg, M.L., Noordermeer, J.N., Tamagnone, L., Comoglio, P.M., Spriggs, M.K., Tessier-Lavigne, M., Goodman, C.S. Cell (1998) [Pubmed]
Plexin B mediates axon guidance in Drosophila by simultaneously inhibiting active Rac and enhancing RhoA signaling. Hu, H., Marton, T.F., Goodman, C.S. Neuron (2001) [Pubmed]
Drosophila Plexin B is a Sema-2a receptor required for axon guidance. Ayoob, J.C., Terman, J.R., Kolodkin, A.L. Development (2006) [Pubmed]

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