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ASMT  -  acetylserotonin O-methyltransferase

Homo sapiens

Synonyms: ASMTY, Acetylserotonin O-methyltransferase, HIOMT, HIOMTY, Hydroxyindole O-methyltransferase
 
 
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Disease relevance of ASMT

 

Psychiatry related information on ASMT

  • The decrease in HIOMT activity in (II) suggests that captivity may affect pineal function, possibly as a consequence of a decrease in locomotor activity [5].
 

High impact information on ASMT

 

Chemical compound and disease context of ASMT

 

Biological context of ASMT

  • The dual promoters and opportunities for alternative splicing suggest a variety of mechanisms for control of HIOMT expression and biological activity in different tissues not previously recognized [12].
  • The HIOMT messages are also alternatively spliced in between exons 6 and 8, generating three distinct messages [12].
  • An antiserum was raised against a mixture of three synthetic peptides, corresponding to three regions of the deduced amino acid sequence of human HIOMT [13].
  • In this study, an HIOMT clone was isolated from a human pineal cDNA library using synthetic oligonucleotide probes based on the bovine HIOMT sequence [13].
  • Aa-nat and Hiomt mRNA and HIOMT activity showed no diurnal rhythm [14].
 

Anatomical context of ASMT

 

Associations of ASMT with chemical compounds

 

Regulatory relationships of ASMT

 

Other interactions of ASMT

  • In captivity illumination affected HIOMT and COMT activites in a similar form to that observed in other species of rodents [5].
  • In (I) the HIOMT activity decreased and the COMT activity increased; no changes were exhibited by HNMT [5].
  • Here we analyzed the effect of tumor necrosis factor-alpha (TNF-alpha) and corticosterone on the transcription of the Aa-nat, hiomt and 14-3-3 protein genes in denervated pineal glands of rats stimulated for 5 hr with norepinephrine, using real-time reverse transcription-polymerase chain reaction [23].
  • Treatment with all-trans-, 13-cis-, and 9-cis-RA induced a gradual 10-fold increase in HIOMT activity and mRNA, without changing the levels of mRNA encoding glyceraldehyde-3-phosphate dehydrogenase, actin, S-antigen, and interphotoreceptor retinoid-binding protein [10].
  • Levels of AA-NAT and HIOMT RNA expression in response to treatment of Y79 cultures with 4 mM dbcAMP or 2 mM butyrate were measured by semi-quantitative reverse-transcription/polymerase chain reaction [11].
 

Analytical, diagnostic and therapeutic context of ASMT

References

  1. Modification of hydroxyindole-O-methyltransferase activity in experimental pineocytomas induced in hamsters by a human papovavirus (JC). Quay, W.B., Ma, Y.H., Varakis, J.N., ZuRhein, G.M., Padgett, B.L., Walker, D.L. J. Natl. Cancer Inst. (1977) [Pubmed]
  2. Hydroxyindole-O-methyltransferase in Y-79 human retinoblastoma cells: effect of cell attachment. Kyritsis, A.P., Wiechmann, A.F., Bok, D., Chader, G.J. J. Neurochem. (1987) [Pubmed]
  3. Melatonin and 5-methoxytryptophol (5-ML) in nervous and/or neurosensory structures of a gastropod mollusc (Helix aspersa maxima): synthesis and diurnal rhythms. Blanc, A., Vivien-Roels, B., Pévet, P., Attia, J., Buisson, B. Gen. Comp. Endocrinol. (2003) [Pubmed]
  4. Serotoninergic and melatoninergic systems are fully expressed in human skin. Slominski, A., Pisarchik, A., Semak, I., Sweatman, T., Wortsman, J., Szczesniewski, A., Slugocki, G., McNulty, J., Kauser, S., Tobin, D.J., Jing, C., Johansson, O. FASEB J. (2002) [Pubmed]
  5. Hydroxyindole-O-methyltransferase (HIOMT), catechol-O-methyltransferase (COMT) and histamine-N-methyltransferase (HNMT) in the pineal gland of the vizcacha (Lagostomus maximus maximus). Guzmán, J.A., Pelzer, L.E., Piezzi, R.S., Scardapane, L., Dominguez, S. J. Neural Transm. (1980) [Pubmed]
  6. Genetic control of melatonin synthesis in the pineal gland of the mouse. Ebihara, S., Marks, T., Hudson, D.J., Menaker, M. Science (1986) [Pubmed]
  7. Gene duplications as a recurrent theme in the evolution of the human pseudoautosomal region 1: isolation of the gene ASMTL. Ried, K., Rao, E., Schiebel, K., Rappold, G.A. Hum. Mol. Genet. (1998) [Pubmed]
  8. Localization of the hydroxyindole-O-methyltransferase gene to the pseudoautosomal region: implications for mapping of psychiatric disorders. Yi, H., Donohue, S.J., Klein, D.C., McBride, O.W. Hum. Mol. Genet. (1993) [Pubmed]
  9. Cyclic AMP and butyrate modulate melatonin synthesis in Y79 human retinoblastoma cells. Wiechmann, A.F., Kyritsis, A.P., Fletcher, R.T., Chader, G.J. J. Neurochem. (1990) [Pubmed]
  10. Retinoic acid increases hydroxyindole-O-methyltransferase activity and mRNA in human Y-79 retinoblastoma cells. Bernard, M., Klein, D.C. J. Neurochem. (1996) [Pubmed]
  11. Regulation of AA-NAT and HIOMT gene expression by butyrate and cyclic AMP in Y79 human retinoblastoma cells. Wiechmann, A.F., Burden, M.A. J. Pineal Res. (1999) [Pubmed]
  12. Structural analysis of the human hydroxyindole-O-methyltransferase gene. Presence of two distinct promoters. Rodriguez, I.R., Mazuruk, K., Schoen, T.J., Chader, G.J. J. Biol. Chem. (1994) [Pubmed]
  13. Human hydroxyindole-O-methyltransferase: presence of LINE-1 fragment in a cDNA clone and pineal mRNA. Donohue, S.J., Roseboom, P.H., Illnerova, H., Weller, J.L., Klein, D.C. DNA Cell Biol. (1993) [Pubmed]
  14. Characterization of human melatonin synthesis using autoptic pineal tissue. Ackermann, K., Bux, R., Rüb, U., Korf, H.W., Kauert, G., Stehle, J.H. Endocrinology (2006) [Pubmed]
  15. Gene expression of the key enzymes of melatonin synthesis in extrapineal tissues of the rat. Stefulj, J., Hörtner, M., Ghosh, M., Schauenstein, K., Rinner, I., Wölfler, A., Semmler, J., Liebmann, P.M. J. Pineal Res. (2001) [Pubmed]
  16. Localization of hydroxyindole O-methyltransferase-synthesizing cells in bovine epithalamus: immunocytochemistry and in-situ hybridization. Sato, T., Deguchi, T., Ichikawa, T., Fujieda, H., Wake, K. Cell Tissue Res. (1991) [Pubmed]
  17. Localization of hydroxyindole-O-methyltransferase in the mammalian pineal gland and retina. Wiechmann, A.F., Bok, D., Horwitz, J. Invest. Ophthalmol. Vis. Sci. (1985) [Pubmed]
  18. An Xp; Yq translocation causing a novel contiguous gene syndrome in brothers with generalized epilepsy, ichthyosis, and attention deficits. Doherty, M.J., Glass, I.A., Bennett, C.L., Cotter, P.D., Watson, N.F., Mitchell, A.L., Bird, T.D., Farrell, D.F. Epilepsia (2003) [Pubmed]
  19. The melatonin receptor subtype MT1 is expressed in human gallbladder epithelia. Aust, S., Thalhammer, T., Humpeler, S., Jäger, W., Klimpfinger, M., Tucek, G., Obrist, P., Marktl, W., Penner, E., Ekmekcioglu, C. J. Pineal Res. (2004) [Pubmed]
  20. Daily variation in the concentration of 5-methoxytryptophol and melatonin in the duck pineal gland and plasma. Zawilska, J.B., Rosiak, J., Vivien-Roels, B., Skene, D.J., Pévet, P., Nowak, J.Z. J. Pineal Res. (2002) [Pubmed]
  21. Hydroxyindole-O-methyltransferase activity in the pineal gland of the muskox (Ovibos moschatus). Tedesco, S.C., Morton, D.J., Reiter, R.J. J. Pineal Res. (1994) [Pubmed]
  22. Possible involvement of neuropeptide Y in the seasonal control of hydroxyindole-O-methyltransferase activity in the pineal gland of the european hamster (Cricetus cricetus). Ribelayga, C., Pévet, P., Simonneaux, V. Brain Res. (1998) [Pubmed]
  23. Effect of TNF-alpha on the melatonin synthetic pathway in the rat pineal gland: basis for a 'feedback' of the immune response on circadian timing. Fernandes, P.A., Cecon, E., Markus, R.P., Ferreira, Z.S. J. Pineal Res. (2006) [Pubmed]
 
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