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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review: 

msn  -  misshapen

Drosophila melanogaster

 
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High impact information on msn

  • Here, we show that Bifocal (Bif), a putative cytoskeletal regulator, is a component of the Msn pathway for regulating R cell growth cone targeting. bif displays strong genetic interaction with msn [1].
  • Loss of msn causes a failure of growth cones to stop at the target, a phenotype similar to loss of dock, whereas overexpression of msn induces pretarget growth cone termination [2].
  • We show that msn acts in the Frizzled (Fz) mediated epithelial planar polarity (EPP) signaling pathway in eyes and wings [3].
  • We have performed a structure-function analysis of Msn in vivo in Drosophila in order to elucidate the mechanism whereby Msn regulates JNK and to determine whether msn, like dock, is required for the correct targeting of photoreceptor axons [4].
  • Mosaic analysis reveals that msn expression is required in photoreceptors in order for their axons to project correctly [4].
 

Biological context of msn

 

Anatomical context of msn

  • The data presented here genetically link msn to two distinct biological events, dorsal closure and photoreceptor axon pathfinding, and thus provide the first evidence that Ste20 kinases of the germinal center kinase family play a role in axonal pathfinding [4].

References

  1. Bifocal is a downstream target of the Ste20-like serine/threonine kinase misshapen in regulating photoreceptor growth cone targeting in Drosophila. Ruan, W., Long, H., Vuong, D.H., Rao, Y. Neuron (2002)
  2. The SH2/SH3 adaptor protein dock interacts with the Ste20-like kinase misshapen in controlling growth cone motility. Ruan, W., Pang, P., Rao, Y. Neuron (1999)
  3. The Drosophila STE20-like kinase misshapen is required downstream of the Frizzled receptor in planar polarity signaling. Paricio, N., Feiguin, F., Boutros, M., Eaton, S., Mlodzik, M. EMBO J. (1999)
  4. The Ste20 kinase misshapen regulates both photoreceptor axon targeting and dorsal closure, acting downstream of distinct signals. Su, Y.C., Maurel-Zaffran, C., Treisman, J.E., Skolnik, E.Y. Mol. Cell. Biol. (2000)
  5. misshapen encodes a protein kinase involved in cell shape control in Drosophila. Treisman, J.E., Ito, N., Rubin, G.M. Gene (1997)
 
 
 
 
 
 
 
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