Gene Review:
HMGA1 - high mobility group AT-hook 1
Canis lupus familiaris
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Disease relevance of HMGA1
- Human and murine HMGA1 non-histone proteins participate in a wide variety of cellular processes including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the induction of neoplastic transformation and promotion of metastatic progression of cancer cells [1].
High impact information on HMGA1
- In this study, we characterised the molecular structure of the canine HMGA1 cDNA, its splice variants and predicted proteins HMGA1a and HMGA1b [1].
- Over-expression of the proteins of HMGA1 is characteristic for various malignant tumours suggesting a relation between high titer of the protein and the neoplastic phenotype [1].
References
- The canine HMGA1. Murua Escobar, H., Soller, J.T., Richter, A., Meyer, B., Winkler, S., Flohr, A.M., Nolte, I., Bullerdiek, J. Gene (2004) [Pubmed]
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