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Dnmt3a  -  DNA (cytosine-5-)-methyltransferase 3 alpha

Rattus norvegicus

Synonyms: DNA (cytosine-5)-methyltransferase 3A
 
 
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High impact information on Dnmt3a

  • The mRNA and protein levels of de novo methyltransferase Dnmt3b increased, whereas those of Dnmt3a and Dnmt1 decreased, during NGF-induced neurite outgrowth [1].
  • We investigated changes in the DNA methylation machinery, namely, de novo DNA methyltransferases (Dnmt3a and 3b), maintenance DNA methyltransferase (Dnmt1), and methyl CpG binding proteins (MBDs), in rat livers during early stages of tumorigenesis [2].

References

  1. DNA methyltransferase 3b regulates nerve growth factor-induced differentiation of PC12 cells by recruiting histone deacetylase 2. Bai, S., Ghoshal, K., Datta, J., Majumder, S., Yoon, S.O., Jacob, S.T. Mol. Cell. Biol. (2005) [Pubmed]
  2. A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats. Ghoshal, K., Li, X., Datta, J., Bai, S., Pogribny, I., Pogribny, M., Huang, Y., Young, D., Jacob, S.T. J. Nutr. (2006) [Pubmed]
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