Gene Review:
NUDT1 - nudix (nucleoside diphosphate linked...
Homo sapiens
Synonyms:
2-hydroxy-dATP diphosphatase, 7,8-dihydro-8-oxoguanine triphosphatase, 8-oxo-dGTPase, MTH1, Nucleoside diphosphate-linked moiety X motif 1, ...
Satoh,
Kuroda,
Yang,
Safrany,
Shears,
Takahashi,
Maraboeuf,
Sakai,
Yakushiji,
Mishima,
Shirakawa,
Iwai,
Hayakawa,
Sekiguchi,
Nakabeppu,
Nakabeppu,
Tsuchimoto,
Ichinoe,
Ohno,
Ide,
Hirano,
Yoshimura,
Tominaga,
Furuichi,
Sakumi,
Bialkowski,
Kasprzak,
Tsuzuki,
Egashira,
Igarashi,
Iwakuma,
Nakatsuru,
Tominaga,
Kawate,
Nakao,
Nakamura,
Ide,
Kura,
Nakabeppu,
Katsuki,
Ishikawa,
Sekiguchi,
Nakabeppu,
Tsuchimoto,
Yamaguchi,
Sakumi,
- Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates. Mishima, M., Sakai, Y., Itoh, N., Kamiya, H., Furuichi, M., Takahashi, M., Yamagata, Y., Iwai, S., Nakabeppu, Y., Shirakawa, M. J. Biol. Chem. (2004)
- Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers. Halford, S.E., Rowan, A.J., Lipton, L., Sieber, O.M., Pack, K., Thomas, H.J., Hodgson, S.V., Bodmer, W.F., Tomlinson, I.P. Am. J. Pathol. (2003)
- Enhanced expression of the 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase gene in human breast tumor cells. Wani, G., Milo, G.E., D'Ambrosio, S.M. Cancer Lett. (1998)
- Biological significance of the defense mechanisms against oxidative damage in nucleic acids caused by reactive oxygen species: from mitochondria to nuclei. Nakabeppu, Y., Tsuchimoto, D., Ichinoe, A., Ohno, M., Ide, Y., Hirano, S., Yoshimura, D., Tominaga, Y., Furuichi, M., Sakumi, K. Ann. N. Y. Acad. Sci. (2004)
- Defense mechanism to oxidative DNA damage in glial cells. Iida, T., Furuta, A., Nakabeppu, Y., Iwaki, T. Neuropathology : official journal of the Japanese Society of Neuropathology. (2004)
- ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Perraud, A.L., Fleig, A., Dunn, C.A., Bagley, L.A., Launay, P., Schmitz, C., Stokes, A.J., Zhu, Q., Bessman, M.J., Penner, R., Kinet, J.P., Scharenberg, A.M. Nature (2001)
- Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase. Tsuzuki, T., Egashira, A., Igarashi, H., Iwakuma, T., Nakatsuru, Y., Tominaga, Y., Kawate, H., Nakao, K., Nakamura, K., Ide, F., Kura, S., Nakabeppu, Y., Katsuki, M., Ishikawa, T., Sekiguchi, M. Proc. Natl. Acad. Sci. U.S.A. (2001)
- A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides. Ishibashi, T., Hayakawa, H., Sekiguchi, M. EMBO Rep. (2003)
- Inhibition of 8-oxo-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) activity of the antimutagenic human MTH1 protein by nucleoside 5'-diphosphates. Bialkowski, K., Kasprzak, K.S. Free Radic. Biol. Med. (2003)
- Functional significance of the conserved residues for the 23-residue module among MTH1 and MutT family proteins. Fujii, Y., Shimokawa, H., Sekiguchi, M., Nakabeppu, Y. J. Biol. Chem. (1999)
- Sensitivity of Escherichia coli (MutT) and human (MTH1) 8-oxo-dGTPases to in vitro inhibition by the carcinogenic metals, nickel(II), copper(II), cobalt(II) and cadmium(II). Porter, D.W., Yakushiji, H., Nakabeppu, Y., Sekiguchi, M., Fivash, M.J., Kasprzak, K.S. Carcinogenesis (1997)
- A valine to methionine polymorphism at codon 83 in the 8-oxo-dGTPase gene MTH1 is not associated with sporadic Parkinson's disease. Satoh, J., Kuroda, Y. Eur. J. Neurol. (2000)
- Identification and characterization of FTSJ2, a novel human nucleolar protein homologous to bacterial ribosomal RNA methyltransferase. Ching, Y.P., Zhou, H.J., Yuan, J.G., Qiang, B.Q., Kung Hf, H.F., Jin, D.Y. Genomics (2002)
- Regulation of intracellular localization of human MTH1, OGG1, and MYH proteins for repair of oxidative DNA damage. Nakabeppu, Y. Prog. Nucleic Acid Res. Mol. Biol. (2001)
- Oxidative damage is increased in human liver tissue adjacent to hepatocellular carcinoma. Jüngst, C., Cheng, B., Gehrke, R., Schmitz, V., Nischalke, H.D., Ramakers, J., Schramel, P., Schirmacher, P., Sauerbruch, T., Caselmann, W.H. Hepatology (2004)
- An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress. Yoshimura, D., Sakumi, K., Ohno, M., Sakai, Y., Furuichi, M., Iwai, S., Nakabeppu, Y. J. Biol. Chem. (2003)
- Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria. Kang, D., Nishida, J., Iyama, A., Nakabeppu, Y., Furuichi, M., Fujiwara, T., Sekiguchi, M., Takeshige, K. J. Biol. Chem. (1995)
- Regulation of expression of the human MTH1 gene encoding 8-oxo-dGTPase. Alternative splicing of transcription products. Oda, H., Nakabeppu, Y., Furuichi, M., Sekiguchi, M. J. Biol. Chem. (1997)
- Role of tryptophan residues in the recognition of mutagenic oxidized nucleotides by human antimutator MTH1 protein. Takahashi, M., Maraboeuf, F., Sakai, Y., Yakushiji, H., Mishima, M., Shirakawa, M., Iwai, S., Hayakawa, H., Sekiguchi, M., Nakabeppu, Y. J. Mol. Biol. (2002)
- Oxidative damage in nucleic acids and Parkinson's disease. Nakabeppu, Y., Tsuchimoto, D., Yamaguchi, H., Sakumi, K. J. Neurosci. Res. (2007)
- Human polynucleotide phosphorylase protein in response to oxidative stress. Hayakawa, H., Sekiguchi, M. Biochemistry (2006)
- 8-Chloro-dGTP, a hypochlorous acid-modified nucleotide, is hydrolyzed by hMTH1, the human MutT homolog. Fujikawa, K., Yakushiji, H., Nakabeppu, Y., Suzuki, T., Masuda, M., Ohshima, H., Kasai, H. FEBS Lett. (2002)
- NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase. Perraud, A.L., Shen, B., Dunn, C.A., Rippe, K., Smith, M.K., Bessman, M.J., Stoddard, B.L., Scharenberg, A.M. J. Biol. Chem. (2003)
- The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cells. Russo, M.T., Blasi, M.F., Chiera, F., Fortini, P., Degan, P., Macpherson, P., Furuichi, M., Nakabeppu, Y., Karran, P., Aquilina, G., Bignami, M. Mol. Cell. Biol. (2004)
- Contribution of hMTH1 to the maintenance of 8-oxoguanine levels in lung DNA of non-small-cell lung cancer patients. Speina, E., Arczewska, K.D., Gackowski, D., Zielińska, M., Siomek, A., Kowalewski, J., Oliński, R., Tudek, B., Kuśmierek, J.T. J. Natl. Cancer Inst. (2005)
- Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates. Yang, X., Safrany, S.T., Shears, S.B. J. Biol. Chem. (1999)
- The absence of Mth1 inactivation and DNA polymerase kappa overexpression in rat mammary carcinomas with frequent A:T to C:G transversions. Okochi, E., Ichimura, S., Sugimura, T., Ushijima, T. Jpn. J. Cancer Res. (2002)