Gene Review:
NFE2L2 - nuclear factor, erythroid 2-like 2
Homo sapiens
Synonyms:
HEBP1, NF-E2-related factor 2, NFE2-related factor 2, NRF2, Nuclear factor erythroid 2-related factor 2, ...
- Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology. Kim, Y.J., Ahn, J.Y., Liang, P., Ip, C., Zhang, Y., Park, Y.M. Cancer Res. (2007)
- Nitric oxide-induced transcriptional up-regulation of protective genes by Nrf2 via the antioxidant response element counteracts apoptosis of neuroblastoma cells. Dhakshinamoorthy, S., Porter, A.G. J. Biol. Chem. (2004)
- Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription. Katoh, Y., Itoh, K., Yoshida, E., Miyagishi, M., Fukamizu, A., Yamamoto, M. Genes Cells (2001)
- Transcription factor Nrf2 protects HepG2 cells against CYP2E1 plus arachidonic acid-dependent toxicity. Gong, P., Cederbaum, A.I. J. Biol. Chem. (2006)
- Dopamine activates Nrf2-regulated neuroprotective pathways in astrocytes and meningeal cells. Shih, A.Y., Erb, H., Murphy, T.H. J. Neurochem. (2007)
- The nuclear matrix protein, NRP/B, enhances Nrf2-mediated oxidative stress responses in breast cancer cells. Seng, S., Avraham, H.K., Jiang, S., Yang, S., Sekine, M., Kimelman, N., Li, H., Avraham, S. Cancer Res. (2007)
- NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Hayes, J.D., McMahon, M. Trends Biochem. Sci. (2009)
- Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features. Solis, L.M., Behrens, C., Dong, W., Suraokar, M., Ozburn, N.C., Moran, C.A., Corvalan, A.H., Biswal, S., Swisher, S.G., Bekele, B.N., Minna, J.D., Stewart, D.J., Wistuba, I.I. Clin. Cancer Res. (2010)
- Mechanistic studies of the nrf2-keap1 signaling pathway*. Zhang, D.D. Drug Metab. Rev. (2006)
- Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway. Kensler, T.W., Wakabayashi, N., Biswal, S. Annu. Rev. Pharmacol. Toxicol. (2007)
- Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Nguyen, T., Sherratt, P.J., Pickett, C.B. Annu. Rev. Pharmacol. Toxicol. (2003)
- Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling. Lo, S.C., Li, X., Henzl, M.T., Beamer, L.J., Hannink, M. EMBO J. (2006)
- Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress. Dinkova-Kostova, A.T., Liby, K.T., Stephenson, K.K., Holtzclaw, W.D., Gao, X., Suh, N., Williams, C., Risingsong, R., Honda, T., Gribble, G.W., Sporn, M.B., Talalay, P. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Nrf2-dependent activation of the antioxidant responsive element by tert-butylhydroquinone is independent of oxidative stress in IMR-32 human neuroblastoma cells. Lee, J.M., Moehlenkamp, J.D., Hanson, J.M., Johnson, J.A. Biochem. Biophys. Res. Commun. (2001)
- Carbon monoxide mediates heme oxygenase 1 induction via Nrf2 activation in hepatoma cells. Lee, B.S., Heo, J., Kim, Y.M., Shim, S.M., Pae, H.O., Kim, Y.M., Chung, H.T. Biochem. Biophys. Res. Commun. (2006)
- Effect of isothiocyanates on nuclear accumulation of NF-kappaB, Nrf2, and thioredoxin in caco-2 cells. Jakubíková, J., Sedlák, J., Bod'o, J., Bao, Y. J. Agric. Food Chem. (2006)
- Neuronal sensitivity to kainic acid is dependent on the Nrf2-mediated actions of the antioxidant response element. Kraft, A.D., Lee, J.M., Johnson, D.A., Kan, Y.W., Johnson, J.A. J. Neurochem. (2006)
- Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2. Huang, H.C., Nguyen, T., Pickett, C.B. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Moi, P., Chan, K., Asunis, I., Cao, A., Kan, Y.W. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells. Hosoya, T., Maruyama, A., Kang, M.I., Kawatani, Y., Shibata, T., Uchida, K., Warabi, E., Noguchi, N., Itoh, K., Yamamoto, M. J. Biol. Chem. (2005)
- Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene. Dhakshinamoorthy, S., Jaiswal, A.K. Oncogene (2001)
- Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: role of mitogen-activated protein kinases and Nrf2. Anwar, A.A., Li, F.Y., Leake, D.S., Ishii, T., Mann, G.E., Siow, R.C. Free Radic. Biol. Med. (2005)
- Bucillamine induces glutathione biosynthesis via activation of the transcription factor Nrf2. Wielandt, A.M., Vollrath, V., Farias, M., Chianale, J. Biochem. Pharmacol. (2006)
- Mechanism of Action of Sulforaphane: Inhibition of p38 Mitogen-Activated Protein Kinase Isoforms Contributing to the Induction of Antioxidant Response Element-Mediated Heme Oxygenase-1 in Human Hepatoma HepG2 Cells. Keum, Y.S., Yu, S., Chang, P.P., Yuan, X., Kim, J.H., Xu, C., Han, J., Agarwal, A., Kong, A.N. Cancer Res. (2006)
- Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells. Role of p38 kinase and Nrf2 transcription factor. Alam, J., Wicks, C., Stewart, D., Gong, P., Touchard, C., Otterbein, S., Choi, A.M., Burow, M.E., Tou, J. J. Biol. Chem. (2000)
- Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C. Rushworth, S.A., Chen, X.L., Mackman, N., Ogborne, R.M., O'Connell, M.A. J. Immunol. (2005)
- Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2: a novel mechanism in Nrf2 activation. Jain, A.K., Mahajan, S., Jaiswal, A.K. J. Biol. Chem. (2008)
- Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer. Homma, S., Ishii, Y., Morishima, Y., Yamadori, T., Matsuno, Y., Haraguchi, N., Kikuchi, N., Satoh, H., Sakamoto, T., Hizawa, N., Itoh, K., Yamamoto, M. Clin. Cancer Res. (2009)
- Small maf (MafG and MafK) proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD(P)H:Quinone oxidoreductase1 gene. Dhakshinamoorthy, S., Jaiswal, A.K. J. Biol. Chem. (2000)
- Novel cytoprotective mechanism of anti-parkinsonian drug deprenyl: PI3K and Nrf2-derived induction of antioxidative proteins. Nakaso, K., Nakamura, C., Sato, H., Imamura, K., Takeshima, T., Nakashima, K. Biochem. Biophys. Res. Commun. (2006)
- Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells. Ogborne, R.M., Rushworth, S.A., O'Connell, M.A. Arterioscler. Thromb. Vasc. Biol. (2005)
- Nrf2 regulates thromboxane synthase gene expression in human lung cells. Yaekashiwa, M., Wang, L.H. DNA Cell Biol. (2003)
- Cloning and characterization of the human glutathione synthetase 5'-flanking region. Lee, T.D., Yang, H., Whang, J., Lu, S.C. Biochem. J. (2005)
- 1,2,3,4,6-penta-O-galloyl-beta-D-glucose up-regulates heme oxygenase-1 expression by stimulating Nrf2 nuclear translocation in an extracellular signal-regulated kinase-dependent manner in HepG2 cells. Pae, H.O., Oh, G.S., Jeong, S.O., Jeong, G.S., Lee, B.S., Choi, B.M., Lee, H.S., Chung, H.T. World J. Gastroenterol. (2006)
- Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene. Wang, Y., Devereux, W., Stewart, T.M., Casero, R.A. Biochem. J. (2001)
- Redox regulation of the transcriptional repressor Bach1. Ishikawa, M., Numazawa, S., Yoshida, T. Free Radic. Biol. Med. (2005)
- Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression. Chen, X.L., Dodd, G., Thomas, S., Zhang, X., Wasserman, M.A., Rovin, B.H., Kunsch, C. Am. J. Physiol. Heart Circ. Physiol. (2006)
- hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2. Marini, M.G., Chan, K., Casula, L., Kan, Y.W., Cao, A., Moi, P. J. Biol. Chem. (1997)
- Activation of the Nrf2/antioxidant response pathway increases IL-8 expression. Zhang, X., Chen, X., Song, H., Chen, H.Z., Rovin, B.H. Eur. J. Immunol. (2005)
- Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression. Wang, Y., Devereux, W., Stewart, T.M., Casero, R.A. Biochem. J. (2002)
- Chromosomal localization of the human NF-E2 family of bZIP transcription factors by fluorescence in situ hybridization. Chan, J.Y., Cheung, M.C., Moi, P., Chan, K., Kan, Y.W. Hum. Genet. (1995)
- Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2. Sun, Z., Zhang, S., Chan, J.Y., Zhang, D.D. Mol. Cell. Biol. (2007)
- Nrf2-Keap1 Signaling Pathway Regulates Human UGT1A1 Expression in Vitro and in Transgenic UGT1 Mice. Yueh, M.F., Tukey, R.H. J. Biol. Chem. (2007)
- Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione. Kwak, M.K., Itoh, K., Yamamoto, M., Sutter, T.R., Kensler, T.W. Mol. Med. (2001)
- Nrf2: a potential molecular target for cancer chemoprevention by natural compounds. Jeong, W.S., Jun, M., Kong, A.N. Antioxid. Redox Signal. (2006)