Gene Review:
NFKBIB - nuclear factor of kappa light polypeptide...
Homo sapiens
Synonyms:
I-kappa-B-beta, IKBB, IkB-B, IkB-beta, IkappaBbeta, ...
- Inactivation of IkappaBbeta by the tax protein of human T-cell leukemia virus type 1: a potential mechanism for constitutive induction of NF-kappaB. McKinsey, T.A., Brockman, J.A., Scherer, D.C., Al-Murrani, S.W., Green, P.L., Ballard, D.W. Mol. Cell. Biol. (1996)
- Negative regulation of transactivation function but not DNA binding of NF-kappaB and AP-1 by IkappaBbeta1 in breast cancer cells. Newton, T.R., Patel, N.M., Bhat-Nakshatri, P., Stauss, C.R., Goulet, R.J., Nakshatri, H. J. Biol. Chem. (1999)
- IkappaB-mediated inhibition of virus-induced beta interferon transcription. Algarté, M., Nguyen, H., Heylbroeck, C., Lin, R., Hiscott, J. J. Virol. (1999)
- Ikappakappa mediates NF-kappaB activation in human immunodeficiency virus-infected cells. Asin, S., Taylor, J.A., Trushin, S., Bren, G., Paya, C.V. J. Virol. (1999)
- IkappaBbeta-related proteins in normal and transformed colonic epithelial cells. Inan, M.S., Place, R., Tolmacheva, V., Wang, Q.S., Hubbard, A.K., Rosenberg, D.W., Giardina, C. Mol. Carcinog. (2000)
- Mechanisms by which IkappaB proteins control NF-kappaB activity. Simeonidis, S., Stauber, D., Chen, G., Hendrickson, W.A., Thanos, D. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. Chen, Y., Vallee, S., Wu, J., Vu, D., Sondek, J., Ghosh, G. Mol. Cell. Biol. (2004)
- Postrepression activation of NF-kappaB requires the amino-terminal nuclear export signal specific to IkappaBalpha. Huang, T.T., Miyamoto, S. Mol. Cell. Biol. (2001)
- Nuclear factor-kappaB activation by the photochemotherapeutic agent verteporfin. Granville, D.J., Carthy, C.M., Jiang, H., Levy, J.G., McManus, B.M., Matroule, J.Y., Piette, J., Hunt, D.W. Blood (2000)
- CD28 mediates a potent costimulatory signal for rapid degradation of IkappaBbeta which is associated with accelerated activation of various NF-kappaB/Rel heterodimers. Harhaj, E.W., Maggirwar, S.B., Good, L., Sun, S.C. Mol. Cell. Biol. (1996)
- Assignment of the IkappaB-beta gene NFKBIB to human chromosome band 19q13.1 by in situ hybridization. Okamoto, T., Ono, T., Hori, M., Yang, J.P., Tetsuka, T., Kawabe, T., Sonta, S. Cytogenet. Cell Genet. (1998)
- KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta x NF-kappaB complexes. Chen, Y., Wu, J., Ghosh, G. J. Biol. Chem. (2003)
- Regulation of IkappaBbeta expression in testis. Budde, L.M., Wu, C., Tilman, C., Douglas, I., Ghosh, S. Mol. Biol. Cell (2002)
- Expression of nuclear factor kappa B components in human endometrium. Page, M., Tuckerman, E.M., Li, T.C., Laird, S.M. J. Reprod. Immunol. (2002)
- Involvement of NF-kappaB and c-myc signaling pathways in the apoptosis of HL-60 cells induced by alkaloids of Tripterygium hypoglaucum (levl.) Hutch. Zhuang, W.J., Fong, C.C., Cao, J., Ao, L., Leung, C.H., Cheung, H.Y., Xiao, P.G., Fong, W.F., Yang, M.S. Phytomedicine (2004)
- Nuclear IkappaBbeta maintains persistent NF-kappaB activation in HIV-1-infected myeloid cells. DeLuca, C., Petropoulos, L., Zmeureanu, D., Hiscott, J. J. Biol. Chem. (1999)
- Phosphorylation of the PEST domain of IkappaBbeta regulates the function of NF-kappaB/IkappaBbeta complexes. McKinsey, T.A., Chu, Z.L., Ballard, D.W. J. Biol. Chem. (1997)
- IkappaBbeta interacts with the retinoid X receptor and inhibits retinoid-dependent transactivation in lipopolysaccharide-treated cells. Na, S.Y., Kim, H.J., Lee, S.K., Choi, H.S., Na, D.S., Lee, M.O., Chung, M., Moore, D.D., Lee, J.W. J. Biol. Chem. (1998)
- beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta. Wu, C., Ghosh, S. J. Biol. Chem. (1999)
- Ribosomal S6 kinase-1 modulates interleukin-1beta-induced persistent activation of NF-{kappa}B through phosphorylation of I{kappa}Bbeta. Xu, S., Bayat, H., Hou, X., Jiang, B. Am. J. Physiol., Cell Physiol. (2006)
- Cell stress and MKK6b-mediated p38 MAP kinase activation inhibit tumor necrosis factor-induced IkappaB phosphorylation and NF-kappaB activation. Alpert, D., Schwenger, P., Han, J., Vilcek, J. J. Biol. Chem. (1999)
- Persistent interleukin-1beta signaling causes long term activation of NFkappaB in a promoter-specific manner in human glial cells. Griffin, B.D., Moynagh, P.N. J. Biol. Chem. (2006)
- The human T-cell leukemia virus type-1 Tax protein regulates the activity of the IkappaB kinase complex. Li, X.H., Murphy, K.M., Palka, K.T., Surabhi, R.M., Gaynor, R.B. J. Biol. Chem. (1999)
- Constitutive activation of NF-kappaB in Ki-ras-transformed prostate epithelial cells. Kim, B.Y., Gaynor, R.B., Song, K., Dritschilo, A., Jung, M. Oncogene (2002)
- Lipopolysaccharide-induced NF-kappaB activation in human endothelial cells involves degradation of IkappaBalpha but not IkappaBbeta. Zen, K., Karsan, A., Eunson, T., Yee, E., Harlan, J.M. Exp. Cell Res. (1998)
- Interleukin-8 up-regulation by neutrophil elastase is mediated by MyD88/IRAK/TRAF-6 in human bronchial epithelium. Walsh, D.E., Greene, C.M., Carroll, T.P., Taggart, C.C., Gallagher, P.M., O'Neill, S.J., McElvaney, N.G. J. Biol. Chem. (2001)