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Gene Review

NNMT  -  nicotinamide N-methyltransferase

Homo sapiens

Synonyms: Nicotinamide N-methyltransferase
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Disease relevance of NNMT


Psychiatry related information on NNMT

  • Developing xenobiotic enzyme inhibitors of NNMT for individuals, or dietary modification for the whole population, could be an important change in thinking on primary and secondary prevention [6].

High impact information on NNMT


Chemical compound and disease context of NNMT


Biological context of NNMT


Anatomical context of NNMT

  • We previously demonstrated that the human nicotinamide N-methytransferase (NNMT) gene was highly expressed in many papillary thyroid cancers and cell lines [1].
  • NNMT gene expression is enhanced in many papillary thyroid cancer cells and activated by hepatocyte nuclear factor (HNF)-1beta [10].
  • COS-1 cells transfected with this construct expressed a high level of NNMT enzymatic activity, and the biochemical properties of this activity were similar to those of human liver NNMT [2].
  • The human liver NNMT cDNA was transcribed in vitro and translated with a reticulocyte lysate system to yield a protein with a molecular mass of approximately 29 kDa that comigrated during SDS-polyacrylamide gel electrophoresis with photoaffinity-labeled human liver NNMT [2].
  • Expression of NNMT was compared in PD and non-PD control cerebella and caudate nucleus [4].

Associations of NNMT with chemical compounds


Regulatory relationships of NNMT


Other interactions of NNMT


Analytical, diagnostic and therapeutic context of NNMT


  1. Activation of nicotinamide N-methyltransferase gene promoter by hepatocyte nuclear factor-1beta in human papillary thyroid cancer cells. Xu, J., Capezzone, M., Xu, X., Hershman, J.M. Mol. Endocrinol. (2005) [Pubmed]
  2. Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization. Aksoy, S., Szumlanski, C.L., Weinshilboum, R.M. J. Biol. Chem. (1994) [Pubmed]
  3. Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer. Roessler, M., Rollinger, W., Palme, S., Hagmann, M.L., Berndt, P., Engel, A.M., Schneidinger, B., Pfeffer, M., Andres, H., Karl, J., Bodenmüller, H., Rüschoff, J., Henkel, T., Rohr, G., Rossol, S., Rösch, W., Langen, H., Zolg, W., Tacke, M. Clin. Cancer Res. (2005) [Pubmed]
  4. Expression of nicotinamide N-methyltransferase (E.C. in the Parkinsonian brain. Parsons, R.B., Smith, M.L., Williams, A.C., Waring, R.H., Ramsden, D.B. J. Neuropathol. Exp. Neurol. (2002) [Pubmed]
  5. Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells. Xu, J., Moatamed, F., Caldwell, J.S., Walker, J.R., Kraiem, Z., Taki, K., Brent, G.A., Hershman, J.M. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  6. Parkinson's disease: the first common neurological disease due to auto-intoxication? Williams, A.C., Cartwright, L.S., Ramsden, D.B. QJM : monthly journal of the Association of Physicians. (2005) [Pubmed]
  7. A genomewide exploration suggests a new candidate gene at chromosome 11q23 as the major determinant of plasma homocysteine levels: results from the GAIT project. Souto, J.C., Blanco-Vaca, F., Soria, J.M., Buil, A., Almasy, L., Ordoñez-Llanos, J., Martín-Campos, J.M., Lathrop, M., Stone, W., Blangero, J., Fontcuberta, J. Am. J. Hum. Genet. (2005) [Pubmed]
  8. Human liver nicotinamide N-methyltransferase: ion-pairing radiochemical assay, biochemical properties and individual variation. Rini, J., Szumlanski, C., Guerciolini, R., Weinshilboum, R.M. Clin. Chim. Acta (1990) [Pubmed]
  9. Nicotinamide homeostasis: a xenobiotic pathway that is key to development and degenerative diseases. Williams, A.C., Ramsden, D.B. Med. Hypotheses (2005) [Pubmed]
  10. Histone deacetylase inhibitor depsipeptide represses nicotinamide N-methyltransferase and hepatocyte nuclear factor-1beta gene expression in human papillary thyroid cancer cells. Xu, J., Hershman, J.M. Thyroid (2006) [Pubmed]
  11. Gene expression analysis of renal carcinoma: adipose differentiation-related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma. Yao, M., Tabuchi, H., Nagashima, Y., Baba, M., Nakaigawa, N., Ishiguro, H., Hamada, K., Inayama, Y., Kishida, T., Hattori, K., Yamada-Okabe, H., Kubota, Y. J. Pathol. (2005) [Pubmed]
  12. Homocyst(e)ine and stroke. Furie, K.L., Kelly, P.J. Seminars in neurology. (2006) [Pubmed]
  13. Human nicotinamide N-methyltransferase pharmacogenetics: gene sequence analysis and promoter characterization. Yan, L., Otterness, D.M., Weinshilboum, R.M. Pharmacogenetics (1999) [Pubmed]
  14. Mouse liver nicotinamide N-methyltransferase pharmacogenetics: biochemical properties and variation in activity among inbred strains. Scheller, T., Orgacka, H., Szumlanski, C.L., Weinshilboum, R.M. Pharmacogenetics (1996) [Pubmed]
  15. Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization. Aksoy, S., Brandriff, B.F., Ward, A., Little, P.F., Weinshilboum, R.M. Genomics (1995) [Pubmed]
  16. High expression of nicotinamide N-methyltransferase in patients with idiopathic Parkinson's disease. Parsons, R.B., Smith, S.W., Waring, R.H., Williams, A.C., Ramsden, D.B. Neurosci. Lett. (2003) [Pubmed]
  17. A direct correlation between nicotinamide N-methyltransferase activity and protein levels in human liver cytosol. Smith, M.L., Burnett, D., Bennett, P., Waring, R.H., Brown, H.M., Williams, A.C., Ramsden, D.B. Biochim. Biophys. Acta (1998) [Pubmed]
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