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PNP  -  purine nucleoside phosphorylase

Homo sapiens

 
 
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Disease relevance of NP

 

Psychiatry related information on NP

  • Detection of respiratory-related arousals was also improved by NP and only 3% could account for mouth breathing respiration [4].
  • Optimum conditions for enzymatic hydrolysis of OCE were 50 degrees C, 2 h of reaction time, 0.1% amylase mixture (alpha-amylase plus glucoamylase), and 0.2% protease NP [5].
 

High impact information on NP

 

Chemical compound and disease context of NP

 

Biological context of NP

 

Anatomical context of NP

 

Associations of NP with chemical compounds

 

Regulatory relationships of NP

 

Other interactions of NP

 

Analytical, diagnostic and therapeutic context of NP

  • 3. With starch gel electrophoresis no NP activity could be detected in the patient's haemolysate [16].
  • No effects on ADA and PNP levels appeared to be induced by chemotherapy [30].
  • Based on this information, ADA and NP activities were examined in a variety of congenital and acquired animal models of dysimmunity [31].
  • The patient's PNP cDNA was amplified by PCR and sequenced [32].
  • In order to prove that these mutations were responsible for the disease state, each of the three mutations was constructed separately by site-directed mutagenesis of the normal PNP cDNA, and each was transiently expressed in COS cells [32].

References

  1. Purine nucleoside phosphorylase (PNP) and adenosine deaminase (ADA) activities examined cytochemically in unfixed lymphocytes of patients with lymphoproliferative disorders. Maeda, K., Ito, K., Yamaguchi, N. Blood (1981) [Pubmed]
  2. Adenosine deaminase and purine nucleoside phosphorylase in childhood lymphoblastic leukemia: relation with differentiation stage, in vitro drug resistance and clinical prognosis. Pieters, R., Huismans, D.R., Loonen, A.H., Peters, G.J., Hählen, K., van der Does-van den Berg, A., van Wering, E.R., Veerman, A.J. Leukemia (1992) [Pubmed]
  3. The correlation of adenosine deaminase and purine nucleoside phosphorylase activities in human lymphocytes subpopulations and in various lymphoid malignancies. Demeocq, F., Viallard, J.L., Boumsell, L., Richard, Y., Chassagne, J., Plagne, R., Lemerle, J., Bernard, A. Leuk. Res. (1982) [Pubmed]
  4. Nasal prongs in the detection of sleep-related disordered breathing in the sleep apnoea/hypopnoea syndrome. Ballester, E., Badia, J.R., Hernández, L., Farré, R., Navajas, D., Montserrat, J.M. Eur. Respir. J. (1998) [Pubmed]
  5. Development and characterization of a flavoring agent from oyster cooker effluent. Kim, D.S., Baek, H.H., Ahn, C.B., Byun, D.S., Jung, K.J., Lee, H.G., Cadwallader, K.R., Kim, H.R. J. Agric. Food Chem. (2000) [Pubmed]
  6. COPII: a membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum. Barlowe, C., Orci, L., Yeung, T., Hosobuchi, M., Hamamoto, S., Salama, N., Rexach, M.F., Ravazzola, M., Amherdt, M., Schekman, R. Cell (1994) [Pubmed]
  7. Mechanism of RNA polymerase II--specific initiation of transcription in vitro: ATP requirement and uncapped runoff transcripts. Bunick, D., Zandomeni, R., Ackerman, S., Weinmann, R. Cell (1982) [Pubmed]
  8. Purine nucleoside phosphorylase deficiency: improved metabolic and immunologic function with erythrocyte transfusions. Rich, K.C., Majias, E., Fox, I.H. N. Engl. J. Med. (1980) [Pubmed]
  9. Deoxyguanosine toxicity on lymphoid cells as a cause for immunosuppression in purine nucleoside phosphorylase deficiency. Chan, T.S. Cell (1978) [Pubmed]
  10. Characterization of a cell culture model for the study of adenosine deaminase- and purine nucleoside phosphorylase-deficient immunologic disease. Ullman, B., Cohen, A., Martin, D.W. Cell (1976) [Pubmed]
  11. Purine nucleoside phosphorylase in chronic lymphocytic leukemia (CLL). Borgers, M., Verhaegen, H., De Brabander, M., De Cree, J., De Cock, W., Thoné, F., Geuens, G. Blood (1978) [Pubmed]
  12. Distribution of terminal deoxynucleotidyl transferase and purine degradative and synthetic enzymes in subpopulations of human thymocytes. Ma, D.D., Sylwestrowicz, T.A., Granger, S., Massaia, M., Franks, R., Janossy, G., Hoffbrand, A.V. J. Immunol. (1982) [Pubmed]
  13. Combined assay of adenosine deaminase, purine nucleoside phosphorylase, and lactate dehydrogenase in the early clinical evaluation of B-chronic lymphocytic leukemia. Vives Corrons, J.L., Rozman, C., Pujades, M.A., Colomer, D., Perez Vila, E., Anegon, I., Gallart, T., Vives Puiggrós, J., Viñolas, N., Montserrat, E. Am. J. Hematol. (1988) [Pubmed]
  14. Differential distribution of purine metabolizing enzymes between glia and neurons. Ceballos, G., Tuttle, J.B., Rubio, R. J. Neurochem. (1994) [Pubmed]
  15. Erythrocyte adenosine deaminase, purine nucleoside phosphorylase and phosphoribosyltransferase activity in patients with Down's syndrome. Puukka, R., Puukka, M., Leppilampi, M., Linna, S.L., Kouvalainen, K. Clin. Chim. Acta (1982) [Pubmed]
  16. An abnormal form of purine nucleoside phosphorylase in a family with a child with severe defective T-cell-and normal B-cell immunity. van Heukelom, L.H., Staal, G.E., Stoop, J.W., Zegers, B.J. Clin. Chim. Acta (1976) [Pubmed]
  17. Adenosine deaminase and purine nucleoside phosphorylase deficiencies: evaluation of therapeutic interventions in eight patients. Markert, M.L., Hershfield, M.S., Schiff, R.I., Buckley, R.H. J. Clin. Immunol. (1987) [Pubmed]
  18. Nucleoside kinases in T and B lymphoblasts distinguished by autoradiography. Osborne, W.R. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  19. Elevated adenosine deaminase and purine nucleoside phosphorylase activity in peripheral blood null lymphocytes from patients with acquired immune deficiency syndrome. Murray, J.L., Loftin, K.C., Munn, C.G., Reuben, J.M., Mansell, P.W., Hersh, E.M. Blood (1985) [Pubmed]
  20. Erythrocyte adenosine deaminase and purine nucleoside phosphorylase activity in gout. Nishizawa, T., Nishida, Y., Akaoka, I., Yoshimura, T. Clin. Chim. Acta (1975) [Pubmed]
  21. Human purine nucleoside phosphorylase and adenosine deaminase: gene transfer into cultured cells and murine hematopoietic stem cells by using recombinant amphotropic retroviruses. McIvor, R.S., Johnson, M.J., Miller, A.D., Pitts, S., Williams, S.R., Valerio, D., Martin, D.W., Verma, I.M. Mol. Cell. Biol. (1987) [Pubmed]
  22. Purinogenic immunodeficiency diseases: clinical features and molecular mechanisms. Mitchell, B.S., Kelley, W.N. Ann. Intern. Med. (1980) [Pubmed]
  23. Elevated erythrocyte adenosine deaminase activity in patients with acquired immunodeficiency syndrome. Cowan, M.J., Brady, R.O., Widder, K.J. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  24. Metabolism of deoxynucleosides by lymphocytes in long-term culture deficient in different purine enzymes. Simmonds, H.A., Goday, A., Morris, G.S., Brolsma, M.F. Biochem. Pharmacol. (1984) [Pubmed]
  25. Proposed explanation for S-adenosylhomocysteine hydrolase deficiency in purine nucleoside phosphorylase and hypoxanthine-guanine phosphoribosyltransferase-deficient patients. Hershfield, M.S. J. Clin. Invest. (1981) [Pubmed]
  26. Methylthioadenosine phosphorylase and purine nucleoside phosphorylase in B-chronic lymphocytic leukemia. Vertongen, F., Mandelbaum, I. Thymus (1984) [Pubmed]
  27. Adenosine deaminase, nucleoside phosphorylase and hypoxanthine-guanine phosphoribosyltransferase activity in normal lymphocyte subpopulations. Davis, S., Rambotti, P. Anticancer Res. (1982) [Pubmed]
  28. Nucleotide and adenosine metabolism in different cell types of human and rat heart. Kochan, Z., Smolenski, R.T., Yacoub, M.H., Seymour, A.L. J. Mol. Cell. Cardiol. (1994) [Pubmed]
  29. Genetic variation in genes associated with arsenic metabolism: glutathione S-transferase omega 1-1 and purine nucleoside phosphorylase polymorphisms in European and indigenous Americans. Yu, L., Kalla, K., Guthrie, E., Vidrine, A., Klimecki, W.T. Environ. Health Perspect. (2003) [Pubmed]
  30. Adenosine deaminase and purine nucleoside phosphorylase activities in peripheral lymphocytes from patients with solid tumours. Russo, M., Giancane, R., Apice, G., Galanti, B. Br. J. Cancer (1981) [Pubmed]
  31. The activity of purine salvage pathway enzymes in murine and horse models of congenital and acquired dysimmunity. Castles, J.J., Gershwin, M.E., Saito, W., Ardans, A., Osburn, B. Dev. Comp. Immunol. (1977) [Pubmed]
  32. Molecular analysis of mutations in a patient with purine nucleoside phosphorylase deficiency. Aust, M.R., Andrews, L.G., Barrett, M.J., Norby-Slycord, C.J., Markert, M.L. Am. J. Hum. Genet. (1992) [Pubmed]
 
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