Gene Review:
NSF - N-ethylmaleimide-sensitive factor
Homo sapiens
Synonyms:
N-ethylmaleimide-sensitive fusion protein, NEM-sensitive fusion protein, SKD2, Vesicle-fusing ATPase, Vesicular-fusion protein NSF
- Cleavage of cellubrevin by tetanus toxin does not affect fusion of early endosomes. Link, E., McMahon, H., Fischer von Mollard, G., Yamasaki, S., Niemann, H., Südhof, T.C., Jahn, R. J. Biol. Chem. (1993)
- Synaptotagmin regulates mast cell functions. Baram, D., Mekori, Y.A., Sagi-Eisenberg, R. Immunol. Rev. (2001)
- A novel class of fusion polypeptides inhibits exocytosis. Matsushita, K., Morrell, C.N., Lowenstein, C.J. Mol. Pharmacol. (2005)
- Inhibition of the membrane fusion machinery prevents exit from the TGN and proteolytic processing by furin. Band, A.M., Määttä, J., Kääriäinen, L., Kuismanen, E. FEBS Lett. (2001)
- Ground reaction forces, bone characteristics, and tibial stress fracture in male runners. Crossley, K., Bennell, K.L., Wrigley, T., Oakes, B.W. Medicine and science in sports and exercise. (1999)
- Early convergence research and education supported by the National Science Foundation. Bainbridge, W.S. Ann. N. Y. Acad. Sci. (2004)
- Cognitive dietary restraint is associated with stress fractures in women runners. Guest, N.S., Barr, S.I. International journal of sport nutrition and exercise metabolism. (2005)
- Teaching engineering ethics using role-playing in a culturally diverse student group. Prince, R.H. Science and engineering ethics. (2006)
- Synaptosomal proteins, beta-soluble N-ethylmaleimide-sensitive factor attachment protein (beta-SNAP), gamma-SNAP and synaptotagmin I in brain of patients with Down syndrome and Alzheimer's disease. Yoo, B.C., Cairns, N., Fountoulakis, M., Lubec, G. Dementia and geriatric cognitive disorders. (2001)
- S-nitrosylation of NSF controls membrane trafficking. Söllner, T.H., Sequeira, S. Cell (2003)
- Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13. McBride, H.M., Rybin, V., Murphy, C., Giner, A., Teasdale, R., Zerial, M. Cell (1999)
- Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro. Rabouille, C., Kondo, H., Newman, R., Hui, N., Freemont, P., Warren, G. Cell (1998)
- Crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion protein. Lenzen, C.U., Steinmann, D., Whiteheart, S.W., Weis, W.I. Cell (1998)
- Brefeldin A, a drug that blocks secretion, prevents the assembly of non-clathrin-coated buds on Golgi cisternae. Orci, L., Tagaya, M., Amherdt, M., Perrelet, A., Donaldson, J.G., Lippincott-Schwartz, J., Klausner, R.D., Rothman, J.E. Cell (1991)
- Gadolinium deposition in nephrogenic fibrosing dermopathy. Boyd, A.S., Zic, J.A., Abraham, J.L. J. Am. Acad. Dermatol. (2007)
- Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs. Fasshauer, D., Sutton, R.B., Brunger, A.T., Jahn, R. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery. Lemons, P.P., Chen, D., Bernstein, A.M., Bennett, M.K., Whiteheart, S.W. Blood (1997)
- On and off membrane dynamics of the endoplasmic reticulum-golgi tethering factor p115 in vivo. Brandon, E., Szul, T., Alvarez, C., Grabski, R., Benjamin, R., Kawai, R., Sztul, E. Mol. Biol. Cell (2006)
- Mast cell degranulation requires N-ethylmaleimide-sensitive factor-mediated SNARE disassembly. Puri, N., Kruhlak, M.J., Whiteheart, S.W., Roche, P.A. J. Immunol. (2003)
- Distinct domains of syntaxin are required for synaptic vesicle fusion complex formation and dissociation. Kee, Y., Lin, R.C., Hsu, S.C., Scheller, R.H. Neuron (1995)
- The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a conformational change in syntaxin. Hanson, P.I., Otto, H., Barton, N., Jahn, R. J. Biol. Chem. (1995)
- Three-dimensional structure of the amino-terminal domain of syntaxin 6, a SNAP-25 C homolog. Misura, K.M., Bock, J.B., Gonzalez, L.C., Scheller, R.H., Weis, W.I. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Expression of vesicular monoamine transporters, synaptosomal-associated protein 25 and syntaxin1: a signature of human small cell lung carcinoma. Graff, L., Castrop, F., Bauer, M., Höfler, H., Gratzl, M. Cancer Res. (2001)
- Differential roles for NSF and GRIP/ABP in AMPA receptor cycling. Braithwaite, S.P., Xia, H., Malenka, R.C. Proc. Natl. Acad. Sci. U.S.A. (2002)
- CD28 stimulation regulates its association with N-ethylmaleimide-sensitive fusion protein and other proteins involved in vesicle sorting. Heller, M., Watts, J.D., Aebersold, R. Proteomics (2001)
- Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus. MacDonald, P.E., Wang, G., Tsuk, S., Dodo, C., Kang, Y., Tang, L., Wheeler, M.B., Cattral, M.S., Lakey, J.R., Salapatek, A.M., Lotan, I., Gaisano, H.Y. Mol. Endocrinol. (2002)
- Stimulation of NSF ATPase activity by alpha-SNAP is required for SNARE complex disassembly and exocytosis. Barnard, R.J., Morgan, A., Burgoyne, R.D. J. Cell Biol. (1997)
- Synaptic transmission: two players team up for a new tune. Jahn, R. Curr. Biol. (1998)
- Intracellular interaction between syntaxin and Munc 18-1 revealed by fluorescence resonance energy transfer. Yerrapureddy, A., Korte, T., Hollmann, S., Nordhoff, M., Ahnert-Hilger, G., Herrmann, A., Veit, M. Mol. Membr. Biol. (2005)
- Novel putative targets of N-ethylmaleimide sensitive fusion protein (NSF) and alpha/beta soluble NSF attachment proteins (SNAPs) include the Pak-binding nucleotide exchange factor betaPIX. Martin, H.G., Henley, J.M., Meyer, G. J. Cell. Biochem. (2006)
- Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking. Bomberger, J.M., Parameswaran, N., Hall, C.S., Aiyar, N., Spielman, W.S. J. Biol. Chem. (2005)
- Gaf-1, a gamma -SNAP-binding protein associated with the mitochondria. Chen, D., Xu, W., He, P., Medrano, E.E., Whiteheart, S.W. J. Biol. Chem. (2001)
- Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein: implications in the regulation of its hexamerization and exocytosis. Liu, Y., Cheng, K., Gong, K., Fu, A.K., Ip, N.Y. J. Biol. Chem. (2006)
- Control of vesicle fusion by a tyrosine phosphatase. Huynh, H., Bottini, N., Williams, S., Cherepanov, V., Musumeci, L., Saito, K., Bruckner, S., Vachon, E., Wang, X., Kruger, J., Chow, C.W., Pellecchia, M., Monosov, E., Greer, P.A., Trimble, W., Downey, G.P., Mustelin, T. Nat. Cell Biol. (2004)
- R-type voltage-gated Ca(2+) channel interacts with synaptic proteins and recruits synaptotagmin to the plasma membrane of Xenopus oocytes. Cohen, R., Atlas, D. Neuroscience (2004)
- Minireview: aquaporin 2 trafficking. Valenti, G., Procino, G., Tamma, G., Carmosino, M., Svelto, M. Endocrinology (2005)
- Target soluble N-ethylmaleimide-sensitive factor attachment protein receptors (t-SNAREs) differently regulate activation and inactivation gating of Kv2.2 and Kv2.1: Implications on pancreatic islet cell Kv channels. Wolf-Goldberg, T., Michaelevski, I., Sheu, L., Gaisano, H.Y., Chikvashvili, D., Lotan, I. Mol. Pharmacol. (2006)
- Role of vesicle-associated membrane protein-2, through Q-soluble N-ethylmaleimide-sensitive factor attachment protein receptor/R-soluble N-ethylmaleimide-sensitive factor attachment protein receptor interaction, in the exocytosis of specific and tertiary granules of human neutrophils. Mollinedo, F., Martín-Martín, B., Calafat, J., Nabokina, S.M., Lazo, P.A. J. Immunol. (2003)
- Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking. Prekeris, R., Yang, B., Oorschot, V., Klumperman, J., Scheller, R.H. Mol. Biol. Cell (1999)
- Combinatorial SNARE complexes modulate the secretion of cytoplasmic granules in human neutrophils. Mollinedo, F., Calafat, J., Janssen, H., Martín-Martín, B., Canchado, J., Nabokina, S.M., Gajate, C. J. Immunol. (2006)
- NSF and p97/VCP: similar at first, different at last. Brunger, A.T., DeLaBarre, B. FEBS Lett. (2003)
- Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production. Suga, K., Tomiyama, T., Mori, H., Akagawa, K. Biochem. J. (2004)
- Crystal structure of the amino-terminal domain of N-ethylmaleimide-sensitive fusion protein. May, A.P., Misura, K.M., Whiteheart, S.W., Weis, W.I. Nat. Cell Biol. (1999)
- Electron cryomicroscopy structure of N-ethyl maleimide sensitive factor at 11 A resolution. Furst, J., Sutton, R.B., Chen, J., Brunger, A.T., Grigorieff, N. EMBO J. (2003)
- N-Ethylmaleimide-sensitive fusion protein contains high and low affinity ATP-binding sites that are functionally distinct. Matveeva, E.A., He, P., Whiteheart, S.W. J. Biol. Chem. (1997)
- Domain structure of an N-ethylmaleimide-sensitive fusion protein involved in vesicular transport. Tagaya, M., Wilson, D.W., Brunner, M., Arango, N., Rothman, J.E. J. Biol. Chem. (1993)