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NTF3  -  neurotrophin 3

Homo sapiens

Synonyms: HDNF, NGF-2, NGF2, NT-3, NT3, ...
 
 
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Disease relevance of NTF3

 

Psychiatry related information on NTF3

 

High impact information on NTF3

 

Chemical compound and disease context of NTF3

 

Biological context of NTF3

 

Anatomical context of NTF3

 

Associations of NTF3 with chemical compounds

 

Physical interactions of NTF3

  • The glial-cell-line-derived neurotrophic factor (GDNF) family receptors alpha (GFRalpha) are cell surface bound glycoproteins that mediate interactions of the GDNF ligand family with the RET receptor [34].
  • At the cellular level, NT3 binding to TrkCT1-tamalin induces Arf6 translocation to the membrane, which in turn causes membrane ruffling and the formation of cellular protrusions [35].
  • These observations suggest that sAPP(alpha) acts as an injury-induced neurotrophic factor that interacts with NGF to enhance neuronal viability using the insulin signaling pathway [36].
 

Enzymatic interactions of NTF3

  • Fibroblast growth factor-1 stimulation leads to phosphorylation of the adaptor protein Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target (SNT-1) on C-terminal tyrosine residues, whereas it is constitutively bound through its N-terminal phosphotyrosine-binding domain (PTB) to FGF receptors (FGFRs) [37].
 

Regulatory relationships of NTF3

 

Other interactions of NTF3

 

Analytical, diagnostic and therapeutic context of NTF3

References

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  4. Brain-derived neurotrophic factor and neurotrophin-3 support the survival and neuritogenesis response of developing cochleovestibular ganglion neurons. Avila, M.A., Varela-Nieto, I., Romero, G., Mato, J.M., Giraldez, F., Van De Water, T.R., Represa, J. Dev. Biol. (1993) [Pubmed]
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  6. Sequential interactions of fibroblast growth factor-2, brain-derived neurotrophic factor, neurotrophin-3, and their receptors define critical periods in the development of cochlear ganglion cells. Hossain, W.A., Brumwell, C.L., Morest, D.K. Exp. Neurol. (2002) [Pubmed]
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  8. Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males. Cheng, C.Y., Hong, C.J., Yu, Y.W., Chen, T.J., Wu, H.C., Tsai, S.J. Brain Res. Mol. Brain Res. (2005) [Pubmed]
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  13. The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Allsopp, T.E., Wyatt, S., Paterson, H.F., Davies, A.M. Cell (1993) [Pubmed]
  14. ADDENDUM: Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Gill, S.S., Patel, N.K., Hotton, G.R., O'sullivan, K., McCarter, R., Bunnage, M., Brooks, D.J., Svendsen, C.N., Heywood, P. Nat. Med. (2006) [Pubmed]
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  16. Nicotine regulates SH-SY5Y neuroblastoma cell proliferation through the release of brain-derived neurotrophic factor. Serres, F., Carney, S.L. Brain Res. (2006) [Pubmed]
  17. Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Gill, S.S., Patel, N.K., Hotton, G.R., O'Sullivan, K., McCarter, R., Bunnage, M., Brooks, D.J., Svendsen, C.N., Heywood, P. Nat. Med. (2003) [Pubmed]
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  21. Novel polymorphisms in the promoter region of the neurotrophin-3 gene and their associations with schizophrenia. Hattori, M., Kunugi, H., Akahane, A., Tanaka, H., Ishida, S., Hirose, T., Morita, R., Yamakawa, K., Nanko, S. Am. J. Med. Genet. (2002) [Pubmed]
  22. Brain-derived neurotrophic factor and neurotrophin-3 induce cell proliferation in the cochleovestibular ganglion through a glycosyl-phosphatidylinositol signaling system. Represa, J., Avila, M.A., Romero, G., Mato, J.M., Giraldez, F., Varela-Nieto, I. Dev. Biol. (1993) [Pubmed]
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  28. A new brain-derived neurotrophic factor transcript and decrease in brain-derived neurotrophic factor transcripts 1, 2 and 3 in Alzheimer's disease parietal cortex. Garzon, D., Yu, G., Fahnestock, M. J. Neurochem. (2002) [Pubmed]
  29. Association study of schizophrenia with polymorphisms at six candidate genes. Virgos, C., Martorell, L., Valero, J., Figuera, L., Civeira, F., Joven, J., Labad, A., Vilella, E. Schizophr. Res. (2001) [Pubmed]
  30. Brain-derived neurotrophic factor-, neurotrophin-3-, and tyrosine kinase receptor-like immunoreactivity in lingual taste bud fields of mature hamster. Ganchrow, D., Ganchrow, J.R., Verdin-Alcazar, M., Whitehead, M.C. J. Comp. Neurol. (2003) [Pubmed]
  31. The influence of inhalative corticosteroids on circulating Nerve Growth Factor, Brain-Derived Neurotrophic Factor and Neurotrophin-3 in allergic asthmatics. Noga, O., Hanf, G., Schäper, C., O'Connor, A., Kunkel, G. Clin. Exp. Allergy (2001) [Pubmed]
  32. Neuroprotection by neurotrophins and GDNF family members in the excitotoxic model of Huntington's disease. Alberch, J., Pérez-Navarro, E., Canals, J.M. Brain Res. Bull. (2002) [Pubmed]
  33. Protection by GDNF and Other Trophic Factors Against the Dopamine-Depleting Effects of Neurotoxic Doses of Methamphetamine. Cass, W.A., Peters, L.E., Harned, M.E., Seroogy, K.B. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
  34. Cloning and characterization of the human GFRA2 locus and investigation of the gene in Hirschsprung disease. Vanhorne, J.B., Gimm, O., Myers, S.M., Kaushik, A., von Deimling, A., Eng, C., Mulligan, L.M. Hum. Genet. (2001) [Pubmed]
  35. A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin. Esteban, P.F., Yoon, H.Y., Becker, J., Dorsey, S.G., Caprari, P., Palko, M.E., Coppola, V., Saragovi, H.U., Randazzo, P.A., Tessarollo, L. J. Cell Biol. (2006) [Pubmed]
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  37. Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells. Manuvakhova, M., Thottassery, J.V., Hays, S., Qu, Z., Rentz, S.S., Westbrook, L., Kern, F.G. Oncogene (2006) [Pubmed]
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  42. The G691S RET polymorphism increases glial cell line-derived neurotrophic factor-induced pancreatic cancer cell invasion by amplifying mitogen-activated protein kinase signaling. Sawai, H., Okada, Y., Kazanjian, K., Kim, J., Hasan, S., Hines, O.J., Reber, H.A., Hoon, D.S., Eibl, G. Cancer Res. (2005) [Pubmed]
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  46. The extracellular domain of p75NTR is necessary to inhibit neurotrophin-3 signaling through TrkA. Mischel, P.S., Smith, S.G., Vining, E.R., Valletta, J.S., Mobley, W.C., Reichardt, L.F. J. Biol. Chem. (2001) [Pubmed]
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  49. Brain-derived neurotrophic factor-, neurotrophin-3-, and tyrosine kinase receptor-like immunoreactivity in lingual taste bud fields of mature hamster after sensory denervation. Ganchrow, D., Ganchrow, J.R., Verdin-Alcazar, M., Whitehead, M.C. J. Comp. Neurol. (2003) [Pubmed]
  50. Tyrosine kinase inhibitor CEP-701 blocks the NTRK1/NGF receptor and limits the invasive capability of prostate cancer cells in vitro. Festuccia, C., Muzi, P., Gravina, G.L., Millimaggi, D., Speca, S., Dolo, V., Ricevuto, E., Vicentini, C., Bologna, M. Int. J. Oncol. (2007) [Pubmed]
 
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