Gene Review:
NTHL1 - nth endonuclease III-like 1 (E. coli)
Homo sapiens
Synonyms:
Bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase, DNA glycoslyase/AP lyase, Endonuclease III-like protein 1, NTH1, OCTS3, ...
- A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue. Takao, M., Kanno, S., Kobayashi, K., Zhang, Q.M., Yonei, S., van der Horst, G.T., Yasui, A. J. Biol. Chem. (2002)
- Lung cancer in smoking patients inversely alters the activity of hOGG1 and hNTH1. Radak, Z., Goto, S., Nakamoto, H., Udud, K., Papai, Z., Horvath, I. Cancer Lett. (2005)
- Protection of pulmonary epithelial cells from oxidative stress by hMYH adenine glycosylase. Kremer, T.M., Rinne, M.L., Xu, Y., Chen, X.M., Kelley, M.R. Respir. Res. (2004)
- Expression of DNA repair protein: MYH, NTH1, and MTH1 in colorectal cancer. Koketsu, S., Watanabe, T., Nagawa, H. Hepatogastroenterology (2004)
- Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA. Hazra, T.K., Izumi, T., Boldogh, I., Imhoff, B., Kow, Y.W., Jaruga, P., Dizdaroglu, M., Mitra, S. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III. Aspinwall, R., Rothwell, D.G., Roldan-Arjona, T., Anselmino, C., Ward, C.J., Cheadle, J.P., Sampson, J.R., Lindahl, T., Harris, P.C., Hickson, I.D. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Differential specificity of human and Escherichia coli endonuclease III and VIII homologues for oxidative base lesions. Katafuchi, A., Nakano, T., Masaoka, A., Terato, H., Iwai, S., Hanaoka, F., Ide, H. J. Biol. Chem. (2004)
- Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity. Marenstein, D.R., Chan, M.K., Altamirano, A., Basu, A.K., Boorstein, R.J., Cunningham, R.P., Teebor, G.W. J. Biol. Chem. (2003)
- Detection of oxidative clustered DNA lesions in X-irradiated mouse skin tissues and human MCF-7 breast cancer cells. Gollapalle, E., Wang, R., Adetolu, R., Tsao, D., Francisco, D., Sigounas, G., Georgakilas, A.G. Radiat. Res. (2007)
- Escherichia coli Nth and human hNTH1 DNA glycosylases are involved in removal of 8-oxoguanine from 8-oxoguanine/guanine mispairs in DNA. Matsumoto, Y., Zhang, Q.M., Takao, M., Yasui, A., Yonei, S. Nucleic Acids Res. (2001)
- Cloning and characterization of a mouse homologue (mNthl1) of Escherichia coli endonuclease III. Sarker, A.H., Ikeda, S., Nakano, H., Terato, H., Ide, H., Imai, K., Akiyama, K., Tsutsui, K., Bo, Z., Kubo, K., Yamamoto, K., Yasui, A., Yoshida, M.C., Seki, S. J. Mol. Biol. (1998)
- Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes. Imai, K., Sarker, A.H., Akiyama, K., Ikeda, S., Yao, M., Tsutsui, K., Shohmori, T., Seki, S. Gene (1998)
- Purification and characterization of human NTH1, a homolog of Escherichia coli endonuclease III. Direct identification of Lys-212 as the active nucleophilic residue. Ikeda, S., Biswas, T., Roy, R., Izumi, T., Boldogh, I., Kurosky, A., Sarker, A.H., Seki, S., Mitra, S. J. Biol. Chem. (1998)
- Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage. Takao, M., Aburatani, H., Kobayashi, K., Yasui, A. Nucleic Acids Res. (1998)
- Cellular repair of oxidatively induced DNA base lesions is defective in prostate cancer cell lines, PC-3 and DU-145. Trzeciak, A.R., Nyaga, S.G., Jaruga, P., Lohani, A., Dizdaroglu, M., Evans, M.K. Carcinogenesis (2004)
- In vitro and in vivo dimerization of human endonuclease III stimulates its activity. Liu, X., Choudhury, S., Roy, R. J. Biol. Chem. (2003)
- Identification of 5-formyluracil DNA glycosylase activity of human hNTH1 protein. Miyabe, I., Zhang, Q.M., Kino, K., Sugiyama, H., Takao, M., Yasui, A., Yonei, S. Nucleic Acids Res. (2002)
- NEIL1 excises 3' end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1. Parsons, J.L., Zharkov, D.O., Dianov, G.L. Nucleic Acids Res. (2005)
- Human NTH1 physically interacts with p53 and proliferating cell nuclear antigen. Oyama, M., Wakasugi, M., Hama, T., Hashidume, H., Iwakami, Y., Imai, R., Hoshino, S., Morioka, H., Ishigaki, Y., Nikaido, O., Matsunaga, T. Biochem. Biophys. Res. Commun. (2004)
- Cell-cycle regulation, intracellular sorting and induced overexpression of the human NTH1 DNA glycosylase involved in removal of formamidopyrimidine residues from DNA. Luna, L., Bjørås, M., Hoff, E., Rognes, T., Seeberg, E. Mutat. Res. (2000)
- The novel DNA glycosylase, NEIL1, protects mammalian cells from radiation-mediated cell death. Rosenquist, T.A., Zaika, E., Fernandes, A.S., Zharkov, D.O., Miller, H., Grollman, A.P. DNA Repair (Amst.) (2003)
- Expression of the oxidative base excision repair enzymes is not induced in TK6 human lymphoblastoid cells after low doses of ionizing radiation. Inoue, M., Shen, G.P., Chaudhry, M.A., Galick, H., Blaisdell, J.O., Wallace, S.S. Radiat. Res. (2004)
- Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2. Dou, H., Mitra, S., Hazra, T.K. J. Biol. Chem. (2003)