Gene Review:
P2RX1 - purinergic receptor P2X, ligand gated ion...
Homo sapiens
Synonyms:
ATP receptor, P2X purinoceptor 1, P2X1, Purinergic receptor
- Lack of evidence for functional ADP-activated human P2X1 receptors supports a role for ATP during hemostasis and thrombosis. Vial, C., Pitt, S.J., Roberts, J., Rolf, M.G., Mahaut-Smith, M.P., Evans, R.J. Blood (2003)
- Feed forward cycle of hypotonic stress-induced ATP release, purinergic receptor activation, and growth stimulation of prostate cancer cells. Nandigama, R., Padmasekar, M., Wartenberg, M., Sauer, H. J. Biol. Chem. (2006)
- P2X1 purinoceptor in human platelets. Molecular cloning and functional characterization after heterologous expression. Sun, B., Li, J., Okahara, K., Kambayashi, J. J. Biol. Chem. (1998)
- Extracellular ATP activates multiple signalling pathways and potentiates growth factor-induced c-fos gene expression in MCF-7 breast cancer cells. Wagstaff, S.C., Bowler, W.B., Gallagher, J.A., Hipskind, R.A. Carcinogenesis (2000)
- ERK, PKC and PI3K/Akt pathways mediate extracellular ATP and adenosine-induced proliferation of U138-MG human glioma cell line. Jacques-Silva, M.C., Bernardi, A., Rodnight, R., Lenz, G. Oncology (2004)
- Molecular physiology of P2X receptors. North, R.A. Physiol. Rev. (2002)
- Reduced vas deferens contraction and male infertility in mice lacking P2X1 receptors. Mulryan, K., Gitterman, D.P., Lewis, C.J., Vial, C., Leckie, B.J., Cobb, A.L., Brown, J.E., Conley, E.C., Buell, G., Pritchard, C.A., Evans, R.J. Nature (2000)
- A G protein mutant that inhibits thrombin and purinergic receptor activation of phospholipase A2. Gupta, S.K., Diez, E., Heasley, L.E., Osawa, S., Johnson, G.L. Science (1990)
- ATP receptor regulation of adenylate cyclase and protein kinase C activity in cultured renal LLC-PK1 cells. Anderson, R.J., Breckon, R., Dixon, B.S. J. Clin. Invest. (1991)
- Calcium-dependent regulation of secretion in biliary epithelial cells: the role of apamin-sensitive SK channels. Feranchak, A.P., Doctor, R.B., Troetsch, M., Brookman, K., Johnson, S.M., Fitz, J.G. Gastroenterology (2004)
- Markers for the development of early prostate cancer. Slater, M.D., Lauer, C., Gidley-Baird, A., Barden, J.A. J. Pathol. (2003)
- P2X1 stimulation promotes thrombin receptor-mediated platelet aggregation. Erhardt, J.A., Toomey, J.R., Douglas, S.A., Johns, D.G. J. Thromb. Haemost. (2006)
- Contribution of conserved glycine residues to ATP action at human P2X1 receptors: mutagenesis indicates that the glycine at position 250 is important for channel function. Digby, H.R., Roberts, J.A., Sutcliffe, M.J., Evans, R.J. J. Neurochem. (2005)
- Overexpression of the platelet P2X1 ion channel in transgenic mice generates a novel prothrombotic phenotype. Oury, C., Kuijpers, M.J., Toth-Zsamboki, E., Bonnefoy, A., Danloy, S., Vreys, I., Feijge, M.A., De Vos, R., Vermylen, J., Heemskerk, J.W., Hoylaerts, M.F. Blood (2003)
- P2X1-mediated ERK2 activation amplifies the collagen-induced platelet secretion by enhancing myosin light chain kinase activation. Toth-Zsamboki, E., Oury, C., Cornelissen, H., De Vos, R., Vermylen, J., Hoylaerts, M.F. J. Biol. Chem. (2003)
- The P2X1 receptor, an adenosine triphosphate-gated cation channel, is expressed in human platelets but not in human blood leukocytes. Clifford, E.E., Parker, K., Humphreys, B.D., Kertesy, S.B., Dubyak, G.R. Blood (1998)
- Smooth muscle and purinergic contraction of the human, rabbit, rat, and mouse testicular capsule. Banks, F.C., Knight, G.E., Calvert, R.C., Turmaine, M., Thompson, C.S., Mikhailidis, D.P., Morgan, R.J., Burnstock, G. Biol. Reprod. (2006)
- The purinergic component of human vas deferens contraction. Banks, F.C., Knight, G.E., Calvert, R.C., Thompson, C.S., Morgan, R.J., Burnstock, G. Fertil. Steril. (2006)
- Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors. Kim, Y.C., Brown, S.G., Harden, T.K., Boyer, J.L., Dubyak, G., King, B.F., Burnstock, G., Jacobson, K.A. J. Med. Chem. (2001)
- Purines and their roles in apoptosis. Chow, S.C., Kass, G.E., Orrenius, S. Neuropharmacology (1997)
- A comparison of the binding characteristics of recombinant P2X1 and P2X2 purinoceptors. Michel, A.D., Lundström, K., Buell, G.N., Surprenant, A., Valera, S., Humphrey, P.P. Br. J. Pharmacol. (1996)
- Co-expression of P2X1 and P2X5 receptor subunits reveals a novel ATP-gated ion channel. Torres, G.E., Haines, W.R., Egan, T.M., Voigt, M.M. Mol. Pharmacol. (1998)
- Hetero-oligomeric assembly of P2X receptor subunits. Specificities exist with regard to possible partners. Torres, G.E., Egan, T.M., Voigt, M.M. J. Biol. Chem. (1999)
- Differential expression of P2X-purinoceptor subtypes in circular and longitudinal muscle of canine colon. Lee, H.K., Ro, S., Keef, K.D., Kathy, K.D., Kim, Y.H., Kim, H.W., Horowitz, B., Sanders, K.M. Neurogastroenterol. Motil. (2005)
- A quantitative analysis of purinoceptor expression in the bladders of patients with symptomatic outlet obstruction. O'Reilly, B.A., Kosaka, A.H., Chang, T.K., Ford, A.P., Popert, R., McMahon, S.B. BJU international. (2001)
- P2 receptor expression profiles in human vascular smooth muscle and endothelial cells. Wang, L., Karlsson, L., Moses, S., Hultgårdh-Nilsson, A., Andersson, M., Borna, C., Gudbjartsson, T., Jern, S., Erlinge, D. J. Cardiovasc. Pharmacol. (2002)
- P2X7 receptor activation-induced contraction and lysis in human saphenous vein smooth muscle. Cario-Toumaniantz, C., Loirand, G., Ladoux, A., Pacaud, P. Circ. Res. (1998)