Gene Review:
PAWR - PRKC, apoptosis, WT1, regulator
Homo sapiens
Synonyms:
PAR4, PRKC apoptosis WT1 regulator protein, Par-4, Prostate apoptosis response 4 protein, par-4
- Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease. Guo, Q., Fu, W., Xie, J., Luo, H., Sells, S.F., Geddes, J.W., Bondada, V., Rangnekar, V.M., Mattson, M.P. Nat. Med. (1998)
- Par4 is a coactivator for a splice isoform-specific transcriptional activation domain in WT1. Richard, D.J., Schumacher, V., Royer-Pokora, B., Roberts, S.G. Genes Dev. (2001)
- Expression and function of the leucine zipper protein Par-4 in apoptosis. Sells, S.F., Han, S.S., Muthukkumar, S., Maddiwar, N., Johnstone, R., Boghaert, E., Gillis, D., Liu, G., Nair, P., Monnig, S., Collini, P., Mattson, M.P., Sukhatme, V.P., Zimmer, S.G., Wood, D.P., McRoberts, J.W., Shi, Y., Rangnekar, V.M. Mol. Cell. Biol. (1997)
- Evidence that Par-4 participates in the pathogenesis of HIV encephalitis. Kruman, I.I., Nath, A., Maragos, W.F., Chan, S.L., Jones, M., Rangnekar, V.M., Jakel, R.J., Mattson, M.P. Am. J. Pathol. (1999)
- Inactivation of the candidate tumor suppressor par-4 in endometrial cancer. Moreno-Bueno, G., Fernandez-Marcos, P.J., Collado, M., Tendero, M.J., Rodriguez-Pinilla, S.M., Garcia-Cao, I., Hardisson, D., Diaz-Meco, M.T., Moscat, J., Serrano, M., Palacios, J. Cancer Res. (2007)
- Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane. Xie, J., Guo, Q. J. Biol. Chem. (2004)
- Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Baas, A.F., Kuipers, J., van der Wel, N.N., Batlle, E., Koerten, H.K., Peters, P.J., Clevers, H.C. Cell (2004)
- The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C. Díaz-Meco, M.T., Municio, M.M., Frutos, S., Sanchez, P., Lozano, J., Sanz, L., Moscat, J. Cell (1996)
- Binding and phosphorylation of par-4 by akt is essential for cancer cell survival. Goswami, A., Burikhanov, R., de Thonel, A., Fujita, N., Goswami, M., Zhao, Y., Eriksson, J.E., Tsuruo, T., Rangnekar, V.M. Mol. Cell (2005)
- Apoptosis by Par-4 in cancer and neurodegenerative diseases. El-Guendy, N., Rangnekar, V.M. Exp. Cell Res. (2003)
- Mapping of the human PAWR (par-4) gene to chromosome 12q21. Johnstone, R.W., Tommerup, N., Hansen, C., Vissing, H., Shi, Y. Genomics (1998)
- Differential involvement of thrombin receptors in Ca2+ release from two different intracellular stores in human platelets. Jardin, I., Ben Amor, N., Bartegi, A., Pariente, J.A., Salido, G.M., Rosado, J.A. Biochem. J. (2007)
- Phosphorylation of Par-4 by protein kinase A is critical for apoptosis. Gurumurthy, S., Goswami, A., Vasudevan, K.M., Rangnekar, V.M. Mol. Cell. Biol. (2005)
- Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. Sanchez, P., De Carcer, G., Sandoval, I.V., Moscat, J., Diaz-Meco, M.T. Mol. Cell. Biol. (1998)
- Identification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cells. El-Guendy, N., Zhao, Y., Gurumurthy, S., Burikhanov, R., Rangnekar, V.M. Mol. Cell. Biol. (2003)
- THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis-response-4 (Par-4) to PML nuclear bodies. Roussigne, M., Cayrol, C., Clouaire, T., Amalric, F., Girard, J.P. Oncogene (2003)
- House dust mite major allergens Der p 1 and Der p 5 activate human airway-derived epithelial cells by protease-dependent and protease-independent mechanisms. Kauffman, H.F., Tamm, M., Timmerman, J.A., Borger, P. Clinical and molecular allergy [electronic resource] : CMA. (2006)
- Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells. Pruitt, K., Ulkü, A.S., Frantz, K., Rojas, R.J., Muniz-Medina, V.M., Rangnekar, V.M., Der, C.J., Shields, J.M. J. Biol. Chem. (2005)
- Prostate apoptosis response gene-4 (par-4) abrogates the survival function of p185(BCR-ABL) in hematopoietic cells. Kukoc-Zivojnov, N., Puccetti, E., Chow, K.U., Bergmann, M., Ruthardt, M., Hoelzer, D., Mitrou, P.S., Weidmann, E., Boehrer, S. Exp. Hematol. (2004)
- Absence of prostate apoptosis response-4 protein in substantia nigra of Parkinson's disease autopsies. Moos, T., Jensen, P.H. Acta Neuropathol. (2004)
- A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1. Johnstone, R.W., See, R.H., Sells, S.F., Wang, J., Muthukkumar, S., Englert, C., Haber, D.A., Licht, J.D., Sugrue, S.P., Roberts, T., Rangnekar, V.M., Shi, Y. Mol. Cell. Biol. (1996)
- Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter. Cheema, S.K., Mishra, S.K., Rangnekar, V.M., Tari, A.M., Kumar, R., Lopez-Berestein, G. J. Biol. Chem. (2003)
- Synthesis of Novel Peptide Inhibitors of Thrombin-induced Platelet Activation. Burke, F.M., Warnock, M., Schmaier, A.H., Mosberg, H.I. Chemical biology & drug design (2006)
- Inhibition of PAR4 signaling mediates ethanol-induced attenuation of platelet function in vitro. Kasuda, S., Sakurai, Y., Shima, M., Morimura, Y., Kudo, R., Takeda, T., Ishitani, A., Yoshioka, A., Hatake, K. Alcohol. Clin. Exp. Res. (2006)
- Do heterotrimeric G proteins redistribute upon G protein-coupled receptor stimulation in platelets? Kahner, B.N., Quinton, T.M., Langan, S., Kunapuli, S.P. Platelets (2006)
- ZIP kinase triggers apoptosis from nuclear PML oncogenic domains. Kawai, T., Akira, S., Reed, J.C. Mol. Cell. Biol. (2003)
- Prostate apoptosis response-4 enhances secretion of amyloid beta peptide 1-42 in human neuroblastoma IMR-32 cells by a caspase-dependent pathway. Guo, Q., Xie, J., Chang, X., Du, H. J. Biol. Chem. (2001)
- Identification of mechanically induced genes in human monocytic cells by DNA microarrays. Ohki, R., Yamamoto, K., Mano, H., Lee, R.T., Ikeda, U., Shimada, K. J. Hypertens. (2002)
- Thrombin inhibits intercellular calcium wave propagation in corneal endothelial cells by modulation of hemichannels and gap junctions. D'hondt, C., Ponsaerts, R., Srinivas, S.P., Vereecke, J., Himpens, B. Invest. Ophthalmol. Vis. Sci. (2007)
- Mutually exclusive expression patterns of Bcl-2 and Par-4 in human prostate tumors consistent with down-regulation of Bcl-2 by Par-4. Qiu, G., Ahmed, M., Sells, S.F., Mohiuddin, M., Weinstein, M.H., Rangnekar, V.M. Oncogene (1999)
- Par-4: an emerging pivotal player in neuronal apoptosis and neurodegenerative disorders. Mattson, M.P., Duan, W., Chan, S.L., Camandola, S. J. Mol. Neurosci. (1999)