Gene Review:
KCNK4 - potassium channel, two pore domain...
Homo sapiens
Synonyms:
K2p4.1, Potassium channel subfamily K member 4, TRAAK, TRAAK1, TWIK-related arachidonic acid-stimulated potassium channel protein, ...
- Lysophospholipids open the two-pore domain mechano-gated K(+) channels TREK-1 and TRAAK. Maingret, F., Patel, A.J., Lesage, F., Lazdunski, M., Honoré, E. J. Biol. Chem. (2000)
- Combined antisense and pharmacological approaches implicate hTASK as an airway O(2) sensing K(+) channel. Hartness, M.E., Lewis, A., Searle, G.J., O'Kelly, I., Peers, C., Kemp, P.J. J. Biol. Chem. (2001)
- TRAAK is a mammalian neuronal mechano-gated K+ channel. Maingret, F., Fosset, M., Lesage, F., Lazdunski, M., Honoré, E. J. Biol. Chem. (1999)
- Cloning of two transcripts, HKT4.1a and HKT4.1b, from the human two-pore K+ channel gene KCNK4. Chromosomal localization, tissue distribution and functional expression. Ozaita, A., Vega-Saenz de Miera, E. Brain Res. Mol. Brain Res. (2002)
- Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano-sensitive K(+) channel. Lesage, F., Maingret, F., Lazdunski, M. FEBS Lett. (2000)
- The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K(+) channels TREK-1 and TRAAK. Meadows, H.J., Chapman, C.G., Duckworth, D.M., Kelsell, R.E., Murdock, P.R., Nasir, S., Rennie, G., Randall, A.D. Brain Res. (2001)
- Antipsychotics inhibit TREK but not TRAAK channels. Thümmler, S., Duprat, F., Lazdunski, M. Biochem. Biophys. Res. Commun. (2007)
- PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels. Lopes, C.M., Rohács, T., Czirják, G., Balla, T., Enyedi, P., Logothetis, D.E. J. Physiol. (Lond.) (2005)
- Trichloroethanol enhances the activity of recombinant human TREK-1 and TRAAK channels. Harinath, S., Sikdar, S.K. Neuropharmacology (2004)
- Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery. Medhurst, A.D., Rennie, G., Chapman, C.G., Meadows, H., Duckworth, M.D., Kelsell, R.E., Gloger, I.I., Pangalos, M.N. Brain Res. Mol. Brain Res. (2001)
- Expression of two-pore domain potassium channels in nonhuman primate sperm. Chow, G.E., Muller, C.H., Curnow, E.C., Hayes, E.S. Fertil. Steril. (2007)
- Expression of stretch-activated potassium channels in human myometrium. Tichenor, J.N., Hansen, E.T., Buxton, I.L. Proc. West. Pharmacol. Soc. (2005)