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Klrg1  -  killer cell lectin-like receptor subfamily...

Mus musculus

Synonyms: 2F1-Ag, Killer cell lectin-like receptor subfamily G member 1, MAFA, MAFA-L, Mafa, ...
 
 
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Disease relevance of Klrg1

  • AIMS/HYPOTHESIS: Effects of the transcription factor v-maf musculoaponeurotic fibrosarcoma oncogene homologue A (MAFA) on the regulation of beta cell gene expression and function were investigated [1].
 

High impact information on Klrg1

  • The mast cell function-associated Ag (MAFA) is an inhibitory C-type lectin that was originally identified on the cell surface of a rat mucosal mast cell line, RBL-2H3 [2].
  • We have cloned the mouse homologue of the rat MAFA gene, and Northern blot analysis revealed that mouse MAFA (mMAFA) gene expression was strongly induced in effector CD8 T cells and lymphokine-activated NK cells but not in effector CD4 T cells and in mouse mast cells [2].
  • Thus, the MAFA molecule in the mouse is a putative inhibitory receptor on anti-viral CD8 T cells induced in vivo and on NK cells [2].
  • Glucose influenced DNA-binding activity of MAFA in rat islets in a bell-shaped manner [1].
  • Our in vitro study provides molecular targets that explain the phenotype of recently reported Mafa-null mice [1].
 

Biological context of Klrg1

  • RBL-2H3 cells with either normal or knocked-down MAFA expression levels are currently examined for their biological responses e.g. FcRI mediated secretion, cell proliferation and cell adhesion [3].
 

Anatomical context of Klrg1

  • NK cell expression of the killer cell lectin-like receptor G1 (KLRG1), the mouse homolog of MAFA, is modulated by MHC class I molecules [4].
  • Thus, MAFA/2F1-Ag may modulate immunological responses on at least two different cell types bridging the specific and innate immune system [5].
  • The molecular basis of the enhanced inhibition observed upon co-clustering MAFA with the FcepsilonRI is most probably the increased concentration of the inhibitory cell components in the immediate proximity of the activation coupling elements [6].
  • The mast cell function-associated antigen (MAFA) is a type II membrane glycoprotein first identified on rat mast cells and basophils [6].
 

Associations of Klrg1 with chemical compounds

  • The 2F1 antigen (2F1-Ag) and rat MAFA are structurally highly conserved and contain a cytoplasmic motif similar to the immunoreceptor tyrosine-based inhibitory motif that is presumably utilized for inhibitory signaling [5].
 

Other interactions of Klrg1

References

 
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