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Gene Review: 

TCP1  -  t-complex 1

Bos taurus

Synonyms: CCT, CCT-alpha, CCT1, T-complex protein 1 subunit alpha, TCP-1-alpha, ...
 
 
 
 
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Physical interactions of TCP1

  • This interaction takes place between the apical domain of the CCT beta subunit and the nucleotide binding domain of Hsc70, and may serve to deliver the unfolded substrate from Hsc70 to the substrate binding region of CCT [1].

References

  1. The structure of CCT-Hsc70 NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin. Cuéllar, J., Martín-Benito, J., Scheres, S.H., Sousa, R., Moro, F., López-Viñas, E., Gómez-Puertas, P., Muga, A., Carrascosa, J.L., Valpuesta, J.M. Nat. Struct. Mol. Biol. (2008) [Pubmed]
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