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Gene Review: 

PHF21A  -  PHD finger protein 21A

Homo sapiens

Synonyms: BHC80, BHC80a, BM-006, BRAF35-HDAC complex protein BHC80, KIAA1696
 
 
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High impact information on PHF21A

  • LSD1 is associated with HDAC1/2; CoREST, a SANT domain-containing corepressor; and BHC80, a PHD domain-containing protein, among others [1].
  • While CoREST positively regulates LSD1 function, BHC80 inhibits CoREST/LSD1-mediated demethylation in vitro and may therefore confer negative regulation [1].
  • Similar to NuRD, BHC contains an Mi2-like subunit, BHC80, and a PHD zinc-finger subunit as well as histone deacetylases 1/2 and an MTA-like subunit, the transcriptional corepressor CoREST [2].
  • A component of BRAF-HDAC complex, BHC80, is required for neonatal survival in mice [3].
  • Human cultured cells also contained two isoforms of BHC80 [4].
 

Biological context of PHF21A

  • The C-terminal region of human BHC80 containing PHD zinc-finger domain was capable of binding directly to each of five other components of BHC, and of organizing BHC mediating transcriptional repression [4].
  • A possible role of BHC80 in spermatogenesis is also suggested [4].
 

Anatomical context of PHF21A

  • Two isoforms of mouse BHC80 were predominantly present in the central nervous system and spermatogenic cells [4].
  • Immunohistochemical analysis showed the presence of mouse BHC80 in the nucleus of neuronal cells in the hippocampus and cerebellum [4].
 

Other interactions of PHF21A

  • Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression [4].

References

  1. Regulation of LSD1 histone demethylase activity by its associated factors. Shi, Y.J., Matson, C., Lan, F., Iwase, S., Baba, T., Shi, Y. Mol. Cell (2005) [Pubmed]
  2. A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. Hakimi, M.A., Bochar, D.A., Chenoweth, J., Lane, W.S., Mandel, G., Shiekhattar, R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. A component of BRAF-HDAC complex, BHC80, is required for neonatal survival in mice. Iwase, S., Shono, N., Honda, A., Nakanishi, T., Kashiwabara, S., Takahashi, S., Baba, T. FEBS Lett. (2006) [Pubmed]
  4. Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression. Iwase, S., Januma, A., Miyamoto, K., Shono, N., Honda, A., Yanagisawa, J., Baba, T. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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