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DACT1  -  dishevelled-binding antagonist of beta...

Homo sapiens

Synonyms: DAPPER, DAPPER1, DPR1, Dapper antagonist of catenin 1, Dapper homolog 1, ...
 
 
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Disease relevance of DACT1

 

High impact information on DACT1

 

Biological context of DACT1

  • Human DAPPER1 gene was located within human genome draft sequence NT_025892.9 (nucleotide position 39378960-39387891 in the forward orientation), and human DAPPER2 gene within NT_007302.10 (nucleotide position 660279-672480 in the reverse orientation) [1].
  • DAPPER1 and DAPPER2 genes were mapped to human chromosome 14q22.3 and 6q27, respectively [1].
  • Furthermore, a CpG island located at the promoter region and exon 1 of the HDPR1 gene was methylated in 22 (51%) of human HCCs [2].
  • Validation of DAPPER for 3D QSAR: conformational search and chirality metric [5].
  • A molecular graphics program, FRODO, shows Trp and the four Phe residues lying in an approximate ring around the active site of HESOD and thus excellently placed to report on active site perturbations [6].
 

Anatomical context of DACT1

  • FRODO pulse sequences may also prove useful for imaging of blood vessels, heart, abdomen, and other areas where motion, flow, or wraparound artifacts limit image quality [7].
 

Associations of DACT1 with chemical compounds

 

Other interactions of DACT1

  • DAPPER1 (799-amino-acids) and DAPPER2 (774-amino-acids) showed 28.8% total-amino-acid identity [1].

References

  1. Identification and characterization of human DAPPER1 and DAPPER2 genes in silico. Katoh, M., Katoh, M. Int. J. Oncol. (2003) [Pubmed]
  2. HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing. Yau, T.O., Chan, C.Y., Chan, K.L., Lee, M.F., Wong, C.M., Fan, S.T., Ng, I.O. Oncogene (2005) [Pubmed]
  3. Solution conformation of d-CTCGAGCTCGAG by two-dimensional NMR: conformational heterogeneity at XhoI cleavage site. Sheth, A., Hosur, R.V., Govil, G., Hosur, M.V., Kannan, K.K., Tan, Z., Miles, H.T. Biochemistry (1989) [Pubmed]
  4. Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation. Zhang, L., Gao, X., Wen, J., Ning, Y., Chen, Y.G. J. Biol. Chem. (2006) [Pubmed]
  5. Validation of DAPPER for 3D QSAR: conformational search and chirality metric. Wildman, S.A., Crippen, G.M. Journal of chemical information and computer sciences. (2003) [Pubmed]
  6. UV spectroscopic studies of human erythrocyte superoxide dismutase. Mailer, K., Addetia, R., Livesey, D.L. J. Inorg. Biochem. (1989) [Pubmed]
  7. FRODO pulse sequences: a new means of eliminating motion, flow, and wraparound artifacts. Edelman, R.R., Atkinson, D.J., Silver, M.S., Loaiza, F.L., Warren, W.S. Radiology. (1988) [Pubmed]
  8. Modulation of cytotoxicity of cytostatic drugs by hemodialysis in vitro and in vivo. Sauer, H., Füger, K., Blumenstein, M. Cancer Treat. Rev. (1990) [Pubmed]
 
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