Gene Review:
PDE4D - phosphodiesterase 4D, cAMP-specific
Homo sapiens
Synonyms:
ACRDYS2, DPDE3, HSPDE4D, PDE43, PDE4DN2, ...
Woo,
Kaushal,
Kissela,
Sekar,
Wolujewicz,
Pal,
Alwell,
Haverbusch,
Ewing,
Miller,
Kleindorfer,
Flaherty,
Chakraborty,
Deka,
Broderick,
Meschia,
Brott,
Brown,
Crook,
Worrall,
Kissela,
Brown,
Rich,
Case,
Evans,
Hague,
Singleton,
Hardy,
Lipworth,
Saleheen,
Bukhari,
Haider,
Nazir,
Khanum,
Shafqat,
Anis,
Frossard,
Hersperger,
Bray-French,
Mazzoni,
Müller,
Bolger,
McCahill,
Huston,
Cheung,
McSorley,
Baillie,
Houslay,
Bartscha,
Ivell,
Persani,
Lania,
Alberti,
Romoli,
Mantovani,
Filetti,
Spada,
Conti,
Bartsch,
Bartlick,
Ivell,
Hakonarson,
- Genotype and haplotype association study of the STRK1 region on 5q12 among Japanese: a case-control study. Nakayama, T., Asai, S., Sato, N., Soma, M. Stroke (2006)
- Familial aggregation, the PDE4D gene, and ischemic stroke in a genetically isolated population. van Rijn, M.J., Slooter, A.J., Schut, A.F., Isaacs, A., Aulchenko, Y.S., Snijders, P.J., Kappelle, L.J., van Swieten, J.C., Oostra, B.A., van Duijn, C.M. Neurology (2005)
- Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease. Lipworth, B.J. Lancet (2005)
- Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Lehnart, S.E., Wehrens, X.H., Reiken, S., Warrier, S., Belevych, A.E., Harvey, R.D., Richter, W., Jin, S.L., Conti, M., Marks, A.R. Cell (2005)
- Association of phosphodiesterase 4D gene polymorphisms with chronic obstructive pulmonary disease: Relationship to interleukin 13 gene polymorphism. Homma, S., Sakamoto, T., Hegab, A.E., Saitoh, W., Nomura, A., Ishii, Y., Morishima, Y., Iizuka, T., Kiwamoto, T., Matsuno, Y., Massoud, H.H., Massoud, H.M., Hassanein, K.M., Sekizawa, K. Int. J. Mol. Med. (2006)
- PGE1 stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases. Terrin, A., Di Benedetto, G., Pertegato, V., Cheung, Y.F., Baillie, G., Lynch, M.J., Elvassore, N., Prinz, A., Herberg, F.W., Houslay, M.D., Zaccolo, M. J. Cell Biol. (2006)
- A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design. Card, G.L., Blasdel, L., England, B.P., Zhang, C., Suzuki, Y., Gillette, S., Fong, D., Ibrahim, P.N., Artis, D.R., Bollag, G., Milburn, M.V., Kim, S.H., Schlessinger, J., Zhang, K.Y. Nat. Biotechnol. (2005)
- Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke. Meschia, J.F., Brott, T.G., Brown, R.D., Crook, R., Worrall, B.B., Kissela, B., Brown, W.M., Rich, S.S., Case, L.D., Evans, E.W., Hague, S., Singleton, A., Hardy, J. Ann. Neurol. (2005)
- Role of FLAP and PDE4D in Myocardial Infarction and Stroke: Target Discovery and Future Treatment Options. Hakonarson, H. Current treatment options in cardiovascular medicine. (2006)
- Palladium-catalyzed cross-coupling reactions for the synthesis of 6, 8-disubstituted 1,7-naphthyridines: a novel class of potent and selective phosphodiesterase type 4D inhibitors. Hersperger, R., Bray-French, K., Mazzoni, L., Müller, T. J. Med. Chem. (2000)
- Comparison of recombinant human PDE4 isoforms: interaction with substrate and inhibitors. Saldou, N., Obernolte, R., Huber, A., Baecker, P.A., Wilhelm, R., Alvarez, R., Li, B., Xia, L., Callan, O., Su, C., Jarnagin, K., Shelton, E.R. Cell. Signal. (1998)
- Prolonged beta adrenoceptor stimulation up-regulates cAMP phosphodiesterase activity in human monocytes by increasing mRNA and protein for phosphodiesterases 4A and 4B. Manning, C.D., McLaughlin, M.M., Livi, G.P., Cieslinski, L.B., Torphy, T.J., Barnette, M.S. J. Pharmacol. Exp. Ther. (1996)
- The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins. Bolger, G.B., McCahill, A., Huston, E., Cheung, Y.F., McSorley, T., Baillie, G.S., Houslay, M.D. J. Biol. Chem. (2003)
- Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoter. Le Jeune, I.R., Shepherd, M., Van Heeke, G., Houslay, M.D., Hall, I.P. J. Biol. Chem. (2002)
- Differential regulation of human antigen-specific Th1 and Th2 lymphocyte responses by isozyme selective cyclic nucleotide phosphodiesterase inhibitors. Essayan, D.M., Kagey-Sobotka, A., Lichtenstein, L.M., Huang, S.K. J. Pharmacol. Exp. Ther. (1997)
- Phosphodiesterases 4D and 7A splice variants in the response of HUVEC cells to TNF-alpha(1). Miró, X., Casacuberta, J.M., Gutiérrez-López, M.D., de Landázuri, M.O., Puigdomènech, P. Biochem. Biophys. Res. Commun. (2000)
- Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase. Verde, I., Pahlke, G., Salanova, M., Zhang, G., Wang, S., Coletti, D., Onuffer, J., Jin, S.L., Conti, M. J. Biol. Chem. (2001)
- Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia. Moon, E., Lee, R., Near, R., Weintraub, L., Wolda, S., Lerner, A. Clin. Cancer Res. (2002)
- ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions. MacKenzie, S.J., Baillie, G.S., McPhee, I., Bolger, G.B., Houslay, M.D. J. Biol. Chem. (2000)
- AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa. Bajpai, M., Fiedler, S.E., Huang, Z., Vijayaraghavan, S., Olson, G.E., Livera, G., Conti, M., Carr, D.W. Biol. Reprod. (2006)
- beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. Baillie, G.S., Sood, A., McPhee, I., Gall, I., Perry, S.J., Lefkowitz, R.J., Houslay, M.D. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Association of phosphodiesterase 4D gene with ischemic stroke in a Pakistani population. Saleheen, D., Bukhari, S., Haider, S.R., Nazir, A., Khanum, S., Shafqat, S., Anis, M.K., Frossard, P. Stroke (2005)
- Long-term regulation of cyclic nucleotide phosphodiesterase type 3B and 4 in 3T3-L1 adipocytes. Oknianska, A., Zmuda-Trzebiatowska, E., Manganiello, V., Degerman, E. Biochem. Biophys. Res. Commun. (2007)
- Relaxin and phosphodiesterases collaborate during decidualization. Bartscha, O., Ivell, R. Ann. N. Y. Acad. Sci. (2004)
- Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cells. MacKenzie, S.J., Houslay, M.D. Biochem. J. (2000)
- RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells. Lynch, M.J., Baillie, G.S., Mohamed, A., Li, X., Maisonneuve, C., Klussmann, E., van Heeke, G., Houslay, M.D. J. Biol. Chem. (2005)
- Phosphodiesterase 4 inhibition synergizes with relaxin signaling to promote decidualization of human endometrial stromal cells. Bartsch, O., Bartlick, B., Ivell, R. J. Clin. Endocrinol. Metab. (2004)
- Induction of specific phosphodiesterase isoforms by constitutive activation of the cAMP pathway in autonomous thyroid adenomas. Persani, L., Lania, A., Alberti, L., Romoli, R., Mantovani, G., Filetti, S., Spada, A., Conti, M. J. Clin. Endocrinol. Metab. (2000)
- Reciprocal regulation of calcium dependent and calcium independent cyclic AMP hydrolysis by protein phosphorylation. Ang, K.L., Antoni, F.A. J. Neurochem. (2002)
- Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epithelium. Barnes, A.P., Livera, G., Huang, P., Sun, C., O'Neal, W.K., Conti, M., Stutts, M.J., Milgram, S.L. J. Biol. Chem. (2005)
- Association of Phosphodiesterase 4D with ischemic stroke: a population-based case-control study. Woo, D., Kaushal, R., Kissela, B., Sekar, P., Wolujewicz, M., Pal, P., Alwell, K., Haverbusch, M., Ewing, I., Miller, R., Kleindorfer, D., Flaherty, M., Chakraborty, R., Deka, R., Broderick, J. Stroke (2006)
- An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics. Willoughby, D., Wong, W., Schaack, J., Scott, J.D., Cooper, D.M. EMBO J. (2006)