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Gene Review

C9orf156  -  chromosome 9 open reading frame 156

Homo sapiens

Synonyms: HSPC219, NAP1, Nef-associated protein 1, Thioesterase NAP1
 
 
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High impact information on C9orf156

  • NAP-1-IgG did not compete with 125I-NAP-1 for binding to neutrophils, which suggests that IgG anti-NAP-1 is a molecular trap that prevents binding of NAP-1 to neutrophils after it diffuses from production sites into the circulation [1].
  • However, at pH 2.0 in 9 M urea approximately 15% of the total NAP-1 could be dissociated from the complex [1].
  • The findings suggest a possible role of NAP1 in chromatin remodeling processes involved in transcription and replication by modulating the local linker histone content [2].
  • Here it was examined how NAP1 interacts with chromatin fibers isolated from HeLa cells [2].
  • In addition to its chemotactic activity for neutrophils, NAP-1 induced chemotactic responses by T lymphocytes and basophils [3].
 

Anatomical context of C9orf156

  • Neutrophil attractant protein-1-immunoglobulin G immune complexes and free anti-NAP-1 antibody in normal human serum [1].
  • The purpose of this study was to determine if NAP-1 interacted with other types of blood leukocytes [3].
  • Neutrophil attractant/activation protein-1 (NAP-1) was previously shown to attract human neutrophils, but not monocytes [3].
  • Thus, the predominant response by human subjects to intradermal NAP-1 was neutrophil accumulation in proximity to dermal blood vessels [4].
 

Associations of C9orf156 with chemical compounds

 

Analytical, diagnostic and therapeutic context of C9orf156

  • The ELISA for free NAP-1 used a monoclonal capture antibody that did not bind NAP-1-IgG [1].
  • The effect of NAP1 on the chromatin fiber structure was examined by scanning/atomic force microscopy [2].
  • NAP1 induced a reversible change toward an extended fiber conformation as demonstrated by sedimentation velocity ultracentrifugation experiments [2].
  • The symmetrical histogram obtained by flow cytometry of neutrophils equilibrated at 0 degree C with fluoresceinated NAP-1 indicates that all neutrophils bound the ligand [3].
  • Intradermal injection into normal human subjects of 40 microliters of NAP-1, over a concentration range of 4 x 10(-8) M to 10(-6) M, caused no symptoms or signs such as wheal-and-flare, itching, induration, or tenderness [4].

References

  1. Neutrophil attractant protein-1-immunoglobulin G immune complexes and free anti-NAP-1 antibody in normal human serum. Sylvester, I., Yoshimura, T., Sticherling, M., Schröder, J.M., Ceska, M., Peichl, P., Leonard, E.J. J. Clin. Invest. (1992) [Pubmed]
  2. NAP1 modulates binding of linker histone H1 to chromatin and induces an extended chromatin fiber conformation. Kepert, J.F., Mazurkiewicz, J., Heuvelman, G.L., Tóth, K.F., Rippe, K. J. Biol. Chem. (2005) [Pubmed]
  3. Leukocyte specificity and binding of human neutrophil attractant/activation protein-1. Leonard, E.J., Skeel, A., Yoshimura, T., Noer, K., Kutvirt, S., Van Epps, D. J. Immunol. (1990) [Pubmed]
  4. Neutrophil recruitment by intradermally injected neutrophil attractant/activation protein-1. Leonard, E.J., Yoshimura, T., Tanaka, S., Raffeld, M. J. Invest. Dermatol. (1991) [Pubmed]
  5. Neutrophil attractant/activation protein-1 (NAP-1) causes human basophil histamine release. White, M.V., Yoshimura, T., Hook, W., Kaliner, M.A., Leonard, E.J. Immunol. Lett. (1989) [Pubmed]
 
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