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VTA1  -  vesicle (multivesicular body) trafficking 1

Homo sapiens

Synonyms: C6orf55, DRG-1, DRG1, Dopamine-responsive gene 1 protein, HSPC228, ...
 
 
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Disease relevance of VTA1

  • Drg1, a novel target for modulating sensitivity to CPT-11 in colon cancer cells [1].
  • Depletion of LIP5 by siRNA also decreases human immunodeficiency virus type 1 (HIV-1) budding by 70% [2].
  • Comparison of overexpression and siRNA phenotypes suggests that the roles of these proteins in MVB formation may be more specifically addressed using RNA interference and that both LIP5 and CHMP5 function in MVB sorting, whereas only LIP5 is required for HIV release [2].
 

High impact information on VTA1

  • Clonogenic and apoptosis assays with AS Drg1-expressing cells showed a 2-fold decrease in the IC50 and a 4-5-fold increase in induction of apoptosis with SN-38 [1].
  • Inhibition of endogenous Drg1 expression in Hct116 cells by stable expression of an antisense (AS) Drg1 cDNA increased the sensitivity of cells to undergo apoptosis by SN-38 [1].
  • These findings suggest that DRG-1 may contribute to the dopamine-induced cell growth, which is negatively regulated by NADE [3].
  • In flow cytometry cell cycle analysis, overexpression of DRG-1 in 293 or PC12 cells increased the population of cells in the S phase with a concomitant decrease in G0/G1 population [3].
  • Furthermore, MTT assay showed that stable expression of DRG-1 in 293 cells could promote cell proliferation, and this promotion was suppressed by overexpression of NADE [3].
 

Biological context of VTA1

  • Conversely, the forced expression of Drg1 in SW620 cells increased the resistance of these cells to SN-38-induced apoptosis by 2-5-fold [1].
  • We found that, like SBP-1, the C. elegans ARC105 homologue MDT-15 is required for fatty acid homeostasis, and show that both SBP-1 and MDT-15 control transcription of genes governing desaturation of stearic acid to oleic acid [4].
  • A recent study has shown that SBP-1, a parasite protein associated with Maurer's clefts in the infected red cell cytosol, is essential for transport of the virulence factor PfEMP-1 [5].
 

Anatomical context of VTA1

  • Moreover, when xenografted in mice, AS Drg1-expressing Hct116 cells were 3-fold more sensitive to CPT-11 as compared with vector transfected Hct116 cells [1].
  • Expression of human dopamine responsive gene-1 (DRG-1) is up-regulated in response to treatment of dopamine in the rat astrocytes [3].
  • In the presented studies, DRG-1 was identified to be a conserved gene in the vertebrate and expressed abundantly in human testis, brain and skeletal muscle [3].
 

Associations of VTA1 with chemical compounds

References

  1. Drg1, a novel target for modulating sensitivity to CPT-11 in colon cancer cells. Motwani, M., Sirotnak, F.M., She, Y., Commes, T., Schwartz, G.K. Cancer Res. (2002) [Pubmed]
  2. The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells. Ward, D.M., Vaughn, M.B., Shiflett, S.L., White, P.L., Pollock, A.L., Hill, J., Schnegelberger, R., Sundquist, W.I., Kaplan, J. J. Biol. Chem. (2005) [Pubmed]
  3. Characterization of human dopamine responsive protein DRG-1 that binds to p75NTR-associated cell death executor NADE. Yu, Y., Wang, J., Yuan, H., Qin, F., Wang, J., Zhang, N., Li, Y.Y., Liu, J., Lu, H. Brain Res. (2006) [Pubmed]
  4. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Yang, F., Vought, B.W., Satterlee, J.S., Walker, A.K., Jim Sun, Z.Y., Watts, J.L., DeBeaumont, R., Saito, R.M., Hyberts, S.G., Yang, S., Macol, C., Iyer, L., Tjian, R., van den Heuvel, S., Hart, A.C., Wagner, G., Näär, A.M. Nature (2006) [Pubmed]
  5. Deciphering the export pathway of malaria surface proteins. Epp, C., Deitsch, K. Trends Parasitol. (2006) [Pubmed]
 
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