Gene Review:
PDGFB - platelet-derived growth factor beta...
Homo sapiens
Synonyms:
IBGC5, PDGF subunit B, PDGF-2, PDGF2, Platelet-derived growth factor B chain, ...
- Induction of growth factor RNA expression in human malignant melanoma: markers of transformation. Albino, A.P., Davis, B.M., Nanus, D.M. Cancer Res. (1991)
- Shear stress magnitude and directionality modulate growth factor gene expression in preconditioned vascular endothelial cells. Passerini, A.G., Milsted, A., Rittgers, S.E. J. Vasc. Surg. (2003)
- Dermatofibrosarcoma protuberans with COL1A1 (exon 18) -PDGFB (exon 2) fusion transcript. Saeki, H., Ohmatsu, H., Hoashi, T., Asano, N., Idezuki, T., Kawabata, Y., Asahina, A., Kikuchi, K., Tamaki, K. Br. J. Dermatol. (2003)
- Expression of the normal human sis/PDGF-2 coding sequence induces cellular transformation. Gazit, A., Igarashi, H., Chiu, I.M., Srinivasan, A., Yaniv, A., Tronick, S.R., Robbins, K.C., Aaronson, S.A. Cell (1984)
- Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis. Collins, T., Ginsburg, D., Boss, J.M., Orkin, S.H., Pober, J.S. Nature (1985)
- Brain-behaviour relationships in people at high genetic risk of schizophrenia. Lymer, G.K., Job, D.E., William, T., Moorhead, J., McIntosh, A.M., Owens, D.G., Johnstone, E.C., Lawrie, S.M. Neuroimage (2006)
- Internal consistency and validity of the Stroke Impact Scale 2.0 (SIS 2.0) and SIS-16 in an Australian sample. Edwards, B., O'Connell, B. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. (2003)
- Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. Simon, M.P., Pedeutour, F., Sirvent, N., Grosgeorge, J., Minoletti, F., Coindre, J.M., Terrier-Lacombe, M.J., Mandahl, N., Craver, R.D., Blin, N., Sozzi, G., Turc-Carel, C., O'Brien, K.P., Kedra, D., Fransson, I., Guilbaud, C., Dumanski, J.P. Nat. Genet. (1997)
- PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model. Sasahara, M., Fries, J.W., Raines, E.W., Gown, A.M., Westrum, L.E., Frosch, M.P., Bonthron, D.T., Ross, R., Collins, T. Cell (1991)
- Production of platelet-derived growth factor-like mitogen by smooth-muscle cells from human atheroma. Libby, P., Warner, S.J., Salomon, R.N., Birinyi, L.K. N. Engl. J. Med. (1988)
- Negative trans-acting mechanisms controlling expression of platelet-derived growth factor A and B MRNA in somatic cell hybrids. Levéen, P., Betsholtz, C., Westermark, B. Exp. Cell Res. (1993)
- Detection of COL1A1-PDGFB fusion transcripts in dermatofibrosarcoma protuberans by reverse transcription-polymerase chain reaction using archival formalin-fixed, paraffin-embedded tissues. Wang, J., Hisaoka, M., Shimajiri, S., Morimitsu, Y., Hashimoto, H. Diagn. Mol. Pathol. (1999)
- Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans. Rubin, B.P., Schuetze, S.M., Eary, J.F., Norwood, T.H., Mirza, S., Conrad, E.U., Bruckner, J.D. J. Clin. Oncol. (2002)
- Sustained complete remission of metastatic dermatofibrosarcoma protuberans with imatinib mesylate. Labropoulos, S.V., Fletcher, J.A., Oliveira, A.M., Papadopoulos, S., Razis, E.D. Anticancer Drugs (2005)
- The cell cycle dependence of c-sis gene expression: artifactual conclusions in cells prepared by chemical but not physical techniques. Press, R.D., Jacobberger, J.W., Samols, D., Goldthwait, D. Cell and tissue kinetics. (1990)
- Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis. Sjöblom, T., Shimizu, A., O'Brien, K.P., Pietras, K., Dal Cin, P., Buchdunger, E., Dumanski, J.P., Ostman, A., Heldin, C.H. Cancer Res. (2001)
- Human PDGFA receptor gene maps to the same region on chromosome 4 as the KIT oncogene. Stenman, G., Eriksson, A., Claesson-Welsh, L. Genes Chromosomes Cancer (1989)
- Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberans. Maki, R.G., Awan, R.A., Dixon, R.H., Jhanwar, S., Antonescu, C.R. Int. J. Cancer (2002)
- Disruption of the PDGFB gene in a 1;22 translocation patient does not cause Costello syndrome. Sutajová, M., Neukirchen, U., Meinecke, P., Czeizel, A.E., Tímár, L., Sólyom, E., Gal, A., Kutsche, K. Genomics (2004)
- Identification and characterization of an essential, activating regulatory element of the human SIS/PDGFB promoter in human megakaryocytes. Jin, H.M., Brady, M.L., Fahl, W.E. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Molecular and Biochemical Analyses of Platelet-Derived Growth Factor Receptor (PDGFR) B, PDGFRA, and KIT Receptors in Chordomas. Tamborini, E., Miselli, F., Negri, T., Lagonigro, M.S., Staurengo, S., Dagrada, G.P., Stacchiotti, S., Pastore, E., Gronchi, A., Perrone, F., Carbone, A., Pierotti, M.A., Casali, P.G., Pilotti, S. Clin. Cancer Res. (2006)
- Detection of COL1A1-PDGFB fusion transcripts and platelet-derived growth factor alpha and beta receptors in giant cell fibroblastoma of the postsacrococcygeal region. Kashima, A., Yamashita, A., Moriguchi, S., Marutsuka, K., Tsumori, S., Yoshizato, K., Ishihara, A., Setoyama, M., Asada, Y. Br. J. Dermatol. (2006)
- Developmental patterns of PDGF B-chain, PDGF-receptor, and alpha-actin expression in human glomerulogenesis. Alpers, C.E., Seifert, R.A., Hudkins, K.L., Johnson, R.J., Bowen-Pope, D.F. Kidney Int. (1992)
- Expression of COL1A1-PDGFB fusion transcripts in superficial adult fibrosarcoma suggests a close relationship to dermatofibrosarcoma protuberans. Sheng, W.Q., Hashimoto, H., Okamoto, S., Ishida, T., Meis-Kindblom, J.M., Kindblom, L.G., Hisaoka, M. J. Pathol. (2001)
- The influence of oxidatively modified low density lipoproteins on expression of platelet-derived growth factor by human monocyte-derived macrophages. Malden, L.T., Chait, A., Raines, E.W., Ross, R. J. Biol. Chem. (1991)
- Regulated expression of the platelet-derived growth factor A chain gene in microvascular endothelial cells. Starksen, N.F., Harsh, G.R., Gibbs, V.C., Williams, L.T. J. Biol. Chem. (1987)
- Regulation of platelet-derived growth factor gene expression by transforming growth factor beta and phorbol ester in human leukemia cell lines. Mäkelä, T.P., Alitalo, R., Paulsson, Y., Westermark, B., Heldin, C.H., Alitalo, K. Mol. Cell. Biol. (1987)
- Differential binding and regulation of platelet-derived growth factor A and B chain isoforms by alpha 2-macroglobulin. Bonner, J.C., Osornio-Vargas, A.R. J. Biol. Chem. (1995)
- Expression of PDGF and PDGF receptor mRNA in glomeruli in IgA nephropathy. Terada, Y., Yamada, T., Nakashima, O., Sasaki, S., Nonoguchi, H., Tomita, K., Marumo, F. J. Am. Soc. Nephrol. (1997)
- Control of the expression of c-sis mRNA in human glioblastoma cells by phorbol ester and transforming growth factor beta 1. Press, R.D., Misra, A., Gillaspy, G., Samols, D., Goldthwait, D.A. Cancer Res. (1989)
- Cytokine production in cerebrospinal fluid after subarachnoid haemorrhage. Kikuchi, T., Okuda, Y., Kaito, N., Abe, T. Neurol. Res. (1995)
- Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance. Maxwell, M., Naber, S.P., Wolfe, H.J., Galanopoulos, T., Hedley-Whyte, E.T., Black, P.M., Antoniades, H.N. J. Clin. Invest. (1990)
- Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation. Hermansson, M., Nistér, M., Betsholtz, C., Heldin, C.H., Westermark, B., Funa, K. Proc. Natl. Acad. Sci. U.S.A. (1988)
- Association of markers for TGFbeta3, TGFbeta2 and TIMP1 with systemic sclerosis. Susol, E., Rands, A.L., Herrick, A., McHugh, N., Barrett, J.H., Ollier, W.E., Worthington, J. Rheumatology (Oxford, England) (2000)
- Analysis of gene mutations in three cases of dermatofibrosarcoma protuberans (DFSP): ordinary DFSP, DFSP with fibrosarcomatous lesion (DFSP-FS) and lung metastasis of DFSP-FS. Saeki, H., Hoashi, T., Tada, Y., Ashida, R., Kuwano, Y., Le Pavoux, A., Tsunemi, Y., Shikada, J., Torii, H., Kawabata, Y., Kikuchi, K., Tamada, Y., Matsumoto, Y., Tamaki, K. J. Dermatol. Sci. (2003)
- Transforming activity of the chimeric sequence formed by the fusion of collagen gene COL1A1 and the platelet derived growth factor b-chain gene in dermatofibrosarcoma protuberans. Greco, A., Fusetti, L., Villa, R., Sozzi, G., Minoletti, F., Mauri, P., Pierotti, M.A. Oncogene (1998)
- COL1A1-PDGFB fusion in a ring chromosome 4 found in a dermatofibrosarcoma protuberans. Navarro, M., Simon, M.P., Migeon, C., Turc-Carel, C., Pedeutour, F. Genes Chromosomes Cancer (1998)
- Expression of recombinant platelet-derived growth factor A- and B-chain homodimers in rat-1 cells and human fibroblasts reveals differences in protein processing and autocrine effects. Bywater, M., Rorsman, F., Bongcam-Rudloff, E., Mark, G., Hammacher, A., Heldin, C.H., Westermark, B., Betsholtz, C. Mol. Cell. Biol. (1988)