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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene: VPS29
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vacuolar protein sorting 29 homolog (S....
Homo sapiens
Synonyms: DC15, DC7, DKFZp564F0223, FLJ20492, hVPS29, MDS007, PEP11, Vacuolar protein sorting 29, vacuolar protein sorting 29 (yeast), Vacuolar protein sorting-associated protein 29, Vesicle protein sorting 29
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Four synthetic cationic peptides, pep6, pep7, pep11 and pep20, were tested alone and in combinations for their antimicrobial activities against economically important plant pathogenic fungi (Phytophthora infestans and Alternaria solani) and bacteria (Erwinia carotovora subsp. carotovora and E. carotovora subsp. atroseptica) [2].
In this study, we show that two of the peptides, pep11 and pep46, control virus assembly and cell entry [1].
With strong and broad-spectrum antimicrobial activities of pep11 and pep20 against fungi and bacteria, and with no antagonistic activities, the expression of these peptides in transgenic potato plants could lead to enhanced disease resistance against these pathogens [2].
VPS29 is a component of a retromer complex for recycling a vacuolar sorting receptor VPS10 from the pre-vacuolar compartment to the Golgi complex[3].
We demonstrate that recombinant hVps29 (human Vps29) displays in vitro phosphatase activity towards a serine-phosphorylated peptide, containing the acidic-cluster dileucine motif of the cytoplasmatic tail of the CI-M6PR[4].
The human Vps29 retromer component is a metallo-phosphoesterase for a cation-independent mannose 6-phosphate receptor substrate peptide [4].
The binuclear Zn2+ centre and phosphate group were modelled into the hVps29 catalytic site and pKa calculations provided further insight into the molecular mechanisms of Vps29 phosphatase activity [4].
The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.
