Gene Review:
ZAK - sterile alpha motif and leucine zipper...
Homo sapiens
Synonyms:
AZK, MLK7, MLT, MLTK, MRK, ...
- ZAK re-programs atrial natriuretic factor expression and induces hypertrophic growth in H9c2 cardiomyoblast cells. Huang, C.Y., Chueh, P.J., Tseng, C.T., Liu, K.Y., Tsai, H.Y., Kuo, W.W., Chou, M.Y., Yang, J.J. Biochem. Biophys. Res. Commun. (2004)
- Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif. Liu, T.C., Huang, C.J., Chu, Y.C., Wei, C.C., Chou, C.C., Chou, M.Y., Chou, C.K., Yang, J.J. Biochem. Biophys. Res. Commun. (2000)
- A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development. Cho, Y.Y., Bode, A.M., Mizuno, H., Choi, B.Y., Choi, H.S., Dong, Z. Cancer Res. (2004)
- Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy. Liu, H., Ruskon-Fourmestraux, A., Lavergne-Slove, A., Ye, H., Molina, T., Bouhnik, Y., Hamoudi, R.A., Diss, T.C., Dogan, A., Megraud, F., Rambaud, J.C., Du, M.Q., Isaacson, P.G. Lancet (2001)
- Molecular cloning of a human cDNA encoding beta-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferase. Sato, T., Furukawa, K., Bakker, H., Van den Eijnden, D.H., Van Die, I. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Identification of Yin-Yang Regulators and a Phosphorylation Consensus for Male Germ Cell-Associated Kinase (MAK)-Related Kinase. Fu, Z., Larson, K.A., Chitta, R.K., Parker, S.A., Turk, B.E., Lawrence, M.W., Kaldis, P., Galaktionov, K., Cohn, S.M., Shabanowitz, J., Hunt, D.F., Sturgill, T.W. Mol. Cell. Biol. (2006)
- Altered multidrug resistance phenotype caused by anthracycline analogues and cytosine arabinoside in myeloid leukemia. Hu, X.F., Slater, A., Kantharidis, P., Rischin, D., Juneja, S., Rossi, R., Lee, G., Parkin, J.D., Zalcberg, J.R. Blood (1999)
- In vitro bone marrow purging of multidrug-resistant cells with a mouse monoclonal antibody directed against Mr 170,000 glycoprotein and a saporin-conjugated anti-mouse antibody. Dinota, A., Tazzari, P.L., Michieli, M., Visani, G., Gobbi, M., Bontadini, A., Tassi, C., Fanin, R., Damiani, D., Grandi, M. Cancer Res. (1990)
- Apparent stronger expression in the human adrenal cortex than in the human adrenal medulla of Mr 170,000-180,000 P-glycoprotein. Sugawara, I., Nakahama, M., Hamada, H., Tsuruo, T., Mori, S. Cancer Res. (1988)
- Migraine MLT-down: an unusual presentation of migraine in patients with aspartame-triggered headaches. Newman, L.C., Lipton, R.B. Headache. (2001)
- An outbreak of multiply-resistant Klebsiella pneumoniae in the Grampian region of Scotland. Hobson, R.P., MacKenzie, F.M., Gould, I.M. J. Hosp. Infect. (1996)
- Apoptosis induction in human breast cancer MRK-nu-1 cells by a polyamine synthesis inhibitor, methylglyoxal bis(cyclopentylamidinohydrazone)(MGBCP). Kaneko, H., Hibasami, H., Mori, K., Kawarada, Y., Nakashima, K. Anticancer Res. (1998)
- MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest. Gross, E.A., Callow, M.G., Waldbaum, L., Thomas, S., Ruggieri, R. J. Biol. Chem. (2002)
- The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway. Tosti, E., Waldbaum, L., Warshaw, G., Gross, E.A., Ruggieri, R. J. Biol. Chem. (2004)
- Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase. Bloem, L.J., Pickard, T.R., Acton, S., Donoghue, M., Beavis, R.C., Knierman, M.D., Wang, X. J. Mol. Cell. Cardiol. (2001)
- Mixed lineage kinase ZAK utilizing MKK7 and not MKK4 to activate the c-Jun N-terminal kinase and playing a role in the cell arrest. Yang, J.J. Biochem. Biophys. Res. Commun. (2002)
- Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA. Wang, X., Mader, M.M., Toth, J.E., Yu, X., Jin, N., Campbell, R.M., Smallwood, J.K., Christe, M.E., Chatterjee, A., Goodson, T., Vlahos, C.J., Matter, W.F., Bloem, L.J. J. Biol. Chem. (2005)
- The product of the t(11;18), an API2-MLT fusion, marks nearly half of gastric MALT type lymphomas without large cell proliferation. Baens, M., Maes, B., Steyls, A., Geboes, K., Marynen, P., De Wolf-Peeters, C. Am. J. Pathol. (2000)
- High-level expression of MRK 16 and MRK 20 murine monoclonal antibody-define proteins (170,000-180,000 P-glycoprotein and 85,000 protein) in leukaemias and malignant lymphomas. Sugawara, I., Kodo, H., Ohkochi, E., Hamada, H., Tsuruo, T., Mori, S. Br. J. Cancer (1989)
- Immunotherapy with subcutaneous low-dose interleukin-2 and the pineal indole melatonin as a new effective therapy in advanced cancers of the digestive tract. Lissoni, P., Barni, S., Tancini, G., Ardizzoia, A., Rovelli, F., Cazzaniga, M., Brivio, F., Piperno, A., Aldeghi, R., Fossati, D. Br. J. Cancer (1993)
- Reaction of melatonin and related indoles with hydroxyl radicals: EPR and spin trapping investigations. Matuszak, Z., Reszka, K., Chignell, C.F. Free Radic. Biol. Med. (1997)
- The neuroprotective activities of melatonin against the Alzheimer beta-protein are not mediated by melatonin membrane receptors. Pappolla, M.A., Simovich, M.J., Bryant-Thomas, T., Chyan, Y.J., Poeggeler, B., Dubocovich, M., Bick, R., Perry, G., Cruz-Sanchez, F., Smith, M.A. J. Pineal Res. (2002)
- Regulation of P-glycoprotein 1 and 2 gene expression and protein activity in two MCF-7/Dox cell line subclones. Davies, R., Budworth, J., Riley, J., Snowden, R., Gescher, A., Gant, T.W. Br. J. Cancer (1996)
- A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle. Yang, J.J. Biochem. Biophys. Res. Commun. (2003)
- Outbreak of a multiresistant Klebsiella pneumoniae strain in an intensive care unit: antibiotic use as risk factor for colonization and infection. Asensio, A., Oliver, A., González-Diego, P., Baquero, F., Pérez-Díaz, J.C., Ros, P., Cobo, J., Palacios, M., Lasheras, D., Cantón, R. Clin. Infect. Dis. (2000)