Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

PEPB - peptidase B

Homo sapiens

Ferrell, R.E. et al., Zuffardi, O. et al., Tanis, R.J. et al., Graf, J.D., Salzano, F.M. et al., et al.

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High impact information on PEPB

Linkage group 3 comprises PEP-B (peptidase B), MPI-1 (mannosephosphate isomerase), SORD (sorbitol dehydrogenase), and mIDH-2 (mitochondrial isocitrate dehydrogenase) [1].
These results are consistent with the OCU-HSA chromosome homoeologies previously reported, except for PEPB [2].
Their gene pool shows a peptidase B variant (PEPB2BAN1) and "private" polymorphism of carbonic anhydrase2 (CA2BAN1) until now observed only among them [3].
Three private polymorphisms, at the 2,3-diphosphoglycerate mutase, peptidase B, and purine nucleoside phosphorylase loci, have been observed, which may be useful in future studies of genetic relationships between Eskimos and other circumpolar populations [4].
Two "private polymorphisms" were encountered, of PEPB in the Pano and CAII in the Baniwa [5].

Biological context of PEPB

The statistical map, in general, agrees with the cytogenetic map and further localizes PEPB to 12q21 [6].

Anatomical context of PEPB

This paper presents the results of an electrophoretic survey of approximately 4000 individuals from Hiroshima and Nagasaki for four erythrocyte enzymes: isocitrate dehydrogenase, peptidase A, peptidase B, and phosphohexose isomerase [7].
In lymphocyte cultures 9% of the cells had either no or two rings, but the patient's RBC had normal activities of the enzymes lactate dehydrogenase B and peptidase B, whose loci are located on the proximal portions of 12p and 12q, respectively [8].

References

Genetic mapping in Xenopus laevis: eight linkage groups established. Graf, J.D. Genetics (1989)
Of rabbit and man: comparative gene mapping. Soulie, J., de Grouchy, J. Hum. Genet. (1982)
Gene flow across tribal barriers and its effect among the Amazonian Içana river Indians. Salzano, F.M., Gershowitz, H., Mohrenweiser, H., Neel, J.V., Smouse, P.E., Mestriner, M.A., Weimer, T.A., Franco, M.H., Simões, A.L., Constans, J. Am. J. Phys. Anthropol. (1986)
The St. Lawrence Island Eskimos: genetic variation and genetic distance. Ferrell, R.E., Chakraborty, R., Gershowitz, H., Laughlin, W.S., Schull, W.J. Am. J. Phys. Anthropol. (1981)
Electrophoretic variants in three Amerindian tribes: the Baniwa, Kanamari, and Central Pano of western Brazil. Mohrenweiser, H., Neel, J.V., Mestriner, M.A., Salzano, F.M., Migliazza, E., Simões, A.L., Yoshihara, C.M. Am. J. Phys. Anthropol. (1979)
Regional assignment of human genes TPI1, GAPDH, LDHB, SHMT, and PEPB on chromosome 12. Law, M.L., Kao, F.T. Cytogenet. Cell Genet. (1979)
The frequency in Japanese of genetic variants of 22 proteins. IV. Acid phosphatase, NADP-isocitrate dehydrogenase, peptidase A, peptidase B and phosphohexose isomerase. Tanis, R.J., Ueda, N., Satoh, C., Ferrell, R.E., Kishi-Moto, S., Neel, J.V., Hamilton, H.B., Ohno, N. Ann. Hum. Genet. (1978)
Ring chromosome and latent centromeres. Zuffardi, O., Danesino, C., Poloni, L., Pavesi, F., Bianchi, C., Gargantini, L. Cytogenet. Cell Genet. (1980)

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PEPB - peptidase B

Homo sapiens

High impact information on PEPB

Biological context of PEPB

Anatomical context of PEPB

References

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