Gene Review:
PFKFB3 - 6-phosphofructo-2-kinase/fructose-2,6...
Homo sapiens
Synonyms:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, 6PF-2-K/Fru-2,6-P2ase 3, 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme, IPFK2, PFK/FBPase 3, ...
- Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect. Minchenko, A., Leshchinsky, I., Opentanova, I., Sang, N., Srinivas, V., Armstead, V., Caro, J. J. Biol. Chem. (2002)
- Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers. Bobarykina, A.Y., Minchenko, D.O., Opentanova, I.L., Moenner, M., Caro, J., Esumi, H., Minchenko, O.H. Acta Biochim. Pol. (2006)
- Insulin induces PFKFB3 gene expression in HT29 human colon adenocarcinoma cells. Riera, L., Manzano, A., Navarro-Sabaté, A., Perales, J.C., Bartrons, R. Biochim. Biophys. Acta (2002)
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and tumor cell glycolysis. Chesney, J. Current opinion in clinical nutrition and metabolic care. (2006)
- PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate. Okar, D.A., Manzano, A., Navarro-Sabatè, A., Riera, L., Bartrons, R., Lange, A.J. Trends Biochem. Sci. (2001)
- The proinflammatory mediator macrophage migration inhibitory factor induces glucose catabolism in muscle. Benigni, F., Atsumi, T., Calandra, T., Metz, C., Echtenacher, B., Peng, T., Bucala, R. J. Clin. Invest. (2000)
- 14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase. Pozuelo Rubio, M., Peggie, M., Wong, B.H., Morrice, N., MacKintosh, C. EMBO J. (2003)
- 6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia. Obach, M., Navarro-Sabaté, A., Caro, J., Kong, X., Duran, J., Gómez, M., Perales, J.C., Ventura, F., Rosa, J.L., Bartrons, R. J. Biol. Chem. (2004)
- Activation of 6-phosphofructo-2-kinase by pp60v-src is an indirect effect. Marchand, M.J., Maisin, L., Hue, L., Rousseau, G.G. Biochem. J. (1992)
- Phosphorylation of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase/PFKFB3 family of glycolytic regulators in human cancer. Bando, H., Atsumi, T., Nishio, T., Niwa, H., Mishima, S., Shimizu, C., Yoshioka, N., Bucala, R., Koike, T. Clin. Cancer Res. (2005)
- Cloning and chromosomal characterization of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 gene (PFKFB3, iPFK2). Mahlknecht, U., Chesney, J., Hoelzer, D., Bucala, R. Int. J. Oncol. (2003)
- Expression and hypoxia-responsiveness of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 in mammary gland malignant cell lines. Minchenko, O.H., Opentanova, I.L., Ogura, T., Minchenko, D.O., Komisarenko, S.V., Caro, J., Esumi, H. Acta Biochim. Pol. (2005)
- An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect. Chesney, J., Mitchell, R., Benigni, F., Bacher, M., Spiegel, L., Al-Abed, Y., Han, J.H., Metz, C., Bucala, R. Proc. Natl. Acad. Sci. U.S.A. (1999)
- High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers. Atsumi, T., Chesney, J., Metz, C., Leng, L., Donnelly, S., Makita, Z., Mitchell, R., Bucala, R. Cancer Res. (2002)
- Anti-CD69 antibodies enhance phorbol-dependent glucose metabolism and Ca2+ levels in human thymocytes. Antagonist effect of cyclosporin A. Conde, M., Montaño, R., Moreno-Aurioles, V.R., Ramirez, R., Sanchez-Mateos, P., Sanchez-Madrid, F., Sobrino, F. J. Leukoc. Biol. (1996)
- Expression of Inducible 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase/PFKFB3 Isoforms in Adipocytes and Their Potential Role in Glycolytic Regulation. Atsumi, T., Nishio, T., Niwa, H., Takeuchi, J., Bando, H., Shimizu, C., Yoshioka, N., Bucala, R., Koike, T. Diabetes (2005)
- Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases. Yalcin, A., Clem, B.F., Simmons, A., Lane, A., Nelson, K., Clem, A.L., Brock, E., Siow, D., Wattenberg, B., Telang, S., Chesney, J. J. Biol. Chem. (2009)
- Evaluation of the role of protein kinase Czeta in insulin-induced heart 6-phosphofructo-2-kinase activation. Mouton, V., Vertommen, D., Bertrand, L., Hue, L., Rider, M.H. Cell. Signal. (2007)
- Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in human brain. Kessler, R., Eschrich, K. Brain Res. Mol. Brain Res. (2001)
- Glucokinase Regulatory Network in Pancreatic {beta}-Cells and Liver. Baltrusch, S., Tiedge, M. Diabetes (2006)
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis. Rider, M.H., Bertrand, L., Vertommen, D., Michels, P.A., Rousseau, G.G., Hue, L. Biochem. J. (2004)
- Molecular cloning, expression, and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/ fructose-2, 6-bisphosphatase gene (PFKFB3). Manzano, A., Rosa, J.L., Ventura, F., Pérez, J.X., Nadal, M., Estivill, X., Ambrosio, S., Gil, J., Bartrons, R. Cytogenet. Cell Genet. (1998)