Gene Review:
PLAG1 - pleiomorphic adenoma gene 1
Homo sapiens
Synonyms:
PSA, Pleiomorphic adenoma gene 1 protein, SGPA, ZNF912, Zinc finger protein PLAG1
Hensen,
Van Valckenborgh,
Kas,
Van de Ven,
Voz,
Debiec-Rychter,
Van Valckenborgh,
Van den Broeck,
Hagemeijer,
Van de Ven,
Kas,
Van Damme,
Voz,
Castilla,
Perrat,
Martinez,
Landrette,
Keys,
Oikemus,
Flanegan,
Heilman,
Garrett,
Dutra,
Anderson,
Pihan,
Wolff,
Liu,
Kas,
Voz,
Hensen,
Meyen,
Van de Ven,
Voz,
Agten,
Van de Ven,
Kas,
- Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations. Kas, K., Voz, M.L., Röijer, E., Aström, A.K., Meyen, E., Stenman, G., Van de Ven, W.J. Nat. Genet. (1997)
- Transcriptional activation capacity of the novel PLAG family of zinc finger proteins. Kas, K., Voz, M.L., Hensen, K., Meyen, E., Van de Ven, W.J. J. Biol. Chem. (1998)
- Amplification of MGC2177, PLAG1, PSMC6P, and LYN in a malignant mixed tumor of salivary gland detected by cDNA microarray with tyramide signal amplification. Tsang, Y.T., Chang, Y.M., Lu, X., Rao, P.H., Lau, C.C., Wong, K.K. Cancer Genet. Cytogenet. (2004)
- Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene. Aström, A.K., Voz, M.L., Kas, K., Röijer, E., Wedell, B., Mandahl, N., Van de Ven, W., Mark, J., Stenman, G. Cancer Res. (1999)
- Amplification and overexpression of the IGF2 regulator PLAG1 in hepatoblastoma. Zatkova, A., Rouillard, J.M., Hartmann, W., Lamb, B.J., Kuick, R., Eckart, M., von Schweinitz, D., Koch, A., Fonatsch, C., Pietsch, T., Hanash, S.M., Wimmer, K. Genes Chromosomes Cancer (2004)
- Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia. Castilla, L.H., Perrat, P., Martinez, N.J., Landrette, S.F., Keys, R., Oikemus, S., Flanegan, J., Heilman, S., Garrett, L., Dutra, A., Anderson, S., Pihan, G.A., Wolff, L., Liu, P.P. Proc. Natl. Acad. Sci. U.S.A. (2004)
- The tumorigenic diversity of the three PLAG family members is associated with different DNA binding capacities. Hensen, K., Van Valckenborgh, I.C., Kas, K., Van de Ven, W.J., Voz, M.L. Cancer Res. (2002)
- Repression of the Transactivating Capacity of the Oncoprotein PLAG1 by SUMOylation. Van Dyck, F., Delvaux, E.L., Van de Ven, W.J., Chavez, M.V. J. Biol. Chem. (2004)
- Sumoylation and acetylation play opposite roles in the transactivation of PLAG1 and PLAGL2. Zheng, G., Yang, Y.C. J. Biol. Chem. (2005)
- Salivary gland tumors in transgenic mice with targeted PLAG1 proto-oncogene overexpression. Declercq, J., Van Dyck, F., Braem, C.V., Van Valckenborgh, I.C., Voz, M., Wassef, M., Schoonjans, L., Van Damme, B., Fiette, L., Van de Ven, W.J. Cancer Res. (2005)
- Wnt pathway is involved in pleomorphic adenomas induced by overexpression of PLAG1 in transgenic mice. Zhao, X., Ren, W., Yang, W., Wang, Y., Kong, H., Wang, L., Yan, L., Xu, G., Fei, J., Fu, J., Zhang, C., Wang, Z. Int. J. Cancer (2006)
- PLAG1 alterations in lipoblastoma: involvement in varied mesenchymal cell types and evidence for alternative oncogenic mechanisms. Gisselsson, D., Hibbard, M.K., Dal Cin, P., Sciot, R., Hsi, B.L., Kozakewich, H.P., Fletcher, J.A. Am. J. Pathol. (2001)
- Characterization of chromosome aberrations in salivary gland tumors by FISH, including multicolor COBRA-FISH. Jin, C., Martins, C., Jin, Y., Wiegant, J., Wennerberg, J., Dictor, M., Gisselsson, D., Strömbeck, B., Fonseca, I., Mitelman, F., Tanke, H.J., Höglund, M., Mertens, F. Genes Chromosomes Cancer (2001)
- Pleomorphic adenoma gene 1 is expressed in cultured benign and malignant salivary gland tumor cells. Queimado, L., Lopes, C., Du, F., Martins, C., Bowcock, A.M., Soares, J., Lovett, M. Lab. Invest. (1999)
- Immunohistochemical evaluation of transglutaminase C in tumours of salivary glands. Lee, C.H., Lee, S.K., Chi, J.G., Park, S.C., Chung, S.I., Saitoh, M., Shrestha, P., Mori, M. Eur. J. Cancer, B, Oral Oncol. (1996)
- Amino acid sequence alignment of bacterial and mammalian pancreatic serine proteases based on topological equivalences. James, M.N., Delbaere, L.T., Brayer, G.D. Can. J. Biochem. (1978)
- PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II. Voz, M.L., Agten, N.S., Van de Ven, W.J., Kas, K. Cancer Res. (2000)
- An intronic polymorphism associated with increased XRCC1 expression, reduced apoptosis and familial breast cancer. Bu, D., Tomlinson, G., Lewis, C.M., Zhang, C., Kildebeck, E., Euhus, D.M. Breast Cancer Res. Treat. (2006)
- The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter. Voz, M.L., Aström, A.K., Kas, K., Mark, J., Stenman, G., Van de Ven, W.J. Oncogene (1998)
- Histologic localization of PLAG1 (pleomorphic adenoma gene 1) in pleomorphic adenoma of the salivary gland: cytogenetic evidence of common origin of phenotypically diverse cells. Debiec-Rychter, M., Van Valckenborgh, I., Van den Broeck, C., Hagemeijer, A., Van de Ven, W.J., Kas, K., Van Damme, B., Voz, M.L. Lab. Invest. (2001)
- Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11. Landrette, S.F., Kuo, Y.H., Hensen, K., Barjesteh van Waalwijk van Doorn-Khosrovani, S., Perrat, P.N., Van de Ven, W.J., Delwel, R., Castilla, L.H. Blood (2005)
- Fluorescence in situ hybridization mapping of breakpoints in pleomorphic adenomas with 8q12-13 abnormalities identifies a subgroup of tumors without PLAG1 involvement. Röijer, E., Kas, K., Behrendt, M., Van de Ven, W., Stenman, G. Genes Chromosomes Cancer (1999)
- CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas. Asp, J., Persson, F., Kost-Alimova, M., Stenman, G. Genes Chromosomes Cancer (2006)