Gene Review:
MBD3 - methyl-CpG binding domain protein 3
Homo sapiens
- Methyl CpG-binding domain protein 3 mediates cancer-selective cytotoxicity by histone deacetylase inhibitors via differential transcriptional reprogramming in lung cancer cells. Noh, E.J., Jang, E.R., Jeong, G., Lee, Y.M., Min, C.K., Lee, J.S. Cancer Res. (2005)
- Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Zhang, Y., Ng, H.H., Erdjument-Bromage, H., Tempst, P., Bird, A., Reinberg, D. Genes Dev. (1999)
- MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing. Jin, S.G., Jiang, C.L., Rauch, T., Li, H., Pfeifer, G.P. J. Biol. Chem. (2005)
- Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes. Hendrich, B., Abbott, C., McQueen, H., Chambers, D., Cross, S., Bird, A. Mamm. Genome (1999)
- MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase. Sakai, H., Urano, T., Ookata, K., Kim, M.H., Hirai, Y., Saito, M., Nojima, Y., Ishikawa, F. J. Biol. Chem. (2002)
- The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. Saito, M., Ishikawa, F. J. Biol. Chem. (2002)
- Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression. Ghoshal, K., Majumder, S., Datta, J., Motiwala, T., Bai, S., Sharma, S.M., Frankel, W., Jacob, S.T. J. Biol. Chem. (2004)
- Identification of a murine methyl cytosine phosphate guanine binding domain-containing factor 3 (MBD3) promoter segment sufficient for driving reporter gene expression in neurons in vitro and in vivo. Jung, B.P., Purushotham, D., Eubanks, J.H. Neuroscience (2007)
- MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex. Jiang, C.L., Jin, S.G., Pfeifer, G.P. J. Biol. Chem. (2004)
- Expression of the genes of methyl-binding domain proteins in human gliomas. Schlegel, J., Güneysu, S., Mennel, H.D. Oncol. Rep. (2002)
- Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. Humphrey, G.W., Wang, Y., Russanova, V.R., Hirai, T., Qin, J., Nakatani, Y., Howard, B.H. J. Biol. Chem. (2001)
- Methylation mediated silencing of TMS1/ASC gene in prostate cancer. Das, P.M., Ramachandran, K., Vanwert, J., Ferdinand, L., Gopisetty, G., Reis, I.M., Singal, R. Mol. Cancer (2006)
- A novel murine beta -defensin expressed in tongue, esophagus, and trachea. Jia, H.P., Wowk, S.A., Schutte, B.C., Lee, S.K., Vivado, A., Tack, B.F., Bevins, C.L., McCray, P.B. J. Biol. Chem. (2000)