The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

PLXNB3  -  plexin B3

Homo sapiens

Synonyms: KIAA1206, PLEXB3, PLEXR, PLXN6, Plexin-B3
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on PLXNB3

  • We have previously shown that plexin B3 is a highly potent stimulator of neurite outgrowth, which makes its gene PLXNB3 an intriguing candidate gene for traits related to human brain development and cerebral connectivity [1].
  • A human specific haplotype in Plexin B3 is associated with verbal performance and brain white matter volume [2].
  • We further demonstrate that plexin-B3 activation by Sema5A mediates functional responses in plexin-B3-expressing cells (either fibroblasts, epithelial and primary endothelial cells) [3].
  • Elevated Phe blocks L1-mediated, but not plexin B3-mediated outgrowth, whereas tyrosine is ineffective [4].
  • When expressed in fibroblasts, the neuronal cell adhesion molecules L1 and plexin B3 strongly increase the length of neurites emanating from cerebellar neurons in co-culture experiments [4].
 

Anatomical context of PLXNB3

  • In order to investigate functional properties of B-plexins, we analyzed the expression of human and murine plexin B3 and expressed full-length human plexins B2 (B2) and B3 (B3) in NIH-3T3 cells [5].
  • These findings suggest that plexin B3 may influence cognitive performance, and the development of white matter in vivo in a way similar to its known stimulating effect on neurite outgrowth in vitro [1].
 

Other interactions of PLXNB3

  • X-linked adrenoleukodystrophy with partial deletion of ALD due to fusion with the neighbor gene, PLXNB3 [6].

References

  1. Plexin B3 is genetically associated with verbal performance and white matter volume in human brain. Rujescu, D., Meisenzahl, E.M., Krejcova, S., Giegling, I., Zetzsche, T., Reiser, M., Born, C.M., Möller, H.J., Veske, A., Gal, A., Finckh, U. Mol. Psychiatry (2007) [Pubmed]
  2. A human specific haplotype in Plexin B3 is associated with verbal performance and brain white matter volume. Rujescu, D., Meisenzahl, E.M., Krejcova, S., Giegling, I., Zetzsche, T., Reiser, M., Born, C.M., Möller, H.J., Veske, A., Gal, A., Finckh, U. Mol. Psychiatry (2007) [Pubmed]
  3. Plexin-B3 is a functional receptor for semaphorin 5A. Artigiani, S., Conrotto, P., Fazzari, P., Gilestro, G.F., Barberis, D., Giordano, S., Comoglio, P.M., Tamagnone, L. EMBO Rep. (2004) [Pubmed]
  4. Elevated phenylalanine levels interfere with neurite outgrowth stimulated by the neuronal cell adhesion molecule L1 in vitro. Hartwig, C., Gal, A., Santer, R., Ullrich, K., Finckh, U., Kreienkamp, H.J. FEBS Lett. (2006) [Pubmed]
  5. Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin. Hartwig, C., Veske, A., Krejcova, S., Rosenberger, G., Finckh, U. BMC neuroscience [electronic resource]. (2005) [Pubmed]
  6. X-linked adrenoleukodystrophy with partial deletion of ALD due to fusion with the neighbor gene, PLXNB3. Matsumoto, T., Miyake, N., Watanabe, Y., Yamanaka, G., Oana, S., Ogiwara, M., Hoshika, A., Sasaki, N., Miyahara, H., Niikawa, N. Am. J. Med. Genet. A (2005) [Pubmed]
 
WikiGenes - Universities