Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene: FGFRL1 - fibroblast growth factor receptor-like 1

Homo sapiens

Synonyms: FGF homologous factor receptor, FGFR5, FGF receptor-like protein 1, FGFR-like protein, FHFR, Fibroblast growth factor receptor 5, Fibroblast growth factor receptor-like 1 precursor, UNQ480/PRO943

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Trueb, B., Kim, I., Trueb, B., Trueb, B., Schild, C., et al.

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Disease relevance of FGFRL1

Recombinant FGFRL1 protein was produced in a baculovirus system with intact disulfide bonds [1].

High impact information on FGFRL1

Signalling by the FGFR-like tyrosine kinase, Kringelchen, is essential for bud detachment in Hydra vulgaris [2].
Small amounts of the FGFRL1 mRNA were also detected in other tissues such as skeletal muscle and heart [1].
Clones for a novel transmembrane receptor termed FGFRL1 were isolated from a subtracted, cartilage-specific cDNA library prepared from chicken sterna [1].
The novel gene (FGFRL1) is located on human chromosome 4 band p16 in close proximity to the gene for FGFR3 [3].
The IIIc isoforms of FGFR1 and 2 and the novel FGFR5 were expressed in the aorta, but expression of the FGF receptor 3 was not detected in cDNAs derived from aortic tissue [4].

Biological context of FGFRL1

Since FGFRL1 appears to be involved in the control of cell proliferation and differentiation, its aberrant expression might contribute to the development and progression of ovarian tumors [5].
In human beings, the FGFRL1 gene is located on chromosome 4, adjacent to the SPON2, CTBP1 and MEAEA genes [6].
These results suggest that FGFR5 may provide a binding site for some other fibroblast growth factors and may regulate some pancreatic function [7].

Anatomical context of FGFRL1

Among 23 adult human tissues, FGFR5 mRNA is preferentially expressed in the pancreas [7].
Recombinant FGFR5 expressed in COS-7 cells is not secreted, but recombinant truncated FGFR5 lacking the predicted transmembrane domain is secreted [7].
As demonstrated by in situ hybridization of 16-day-old embryos, the Fgfrl1 mRNA occurs in cartilaginous structures such as the primordia of bones and the permanent cartilage of the trachea, the ribs and the nose [8].

Associations of FGFRL1 with chemical compounds

A unique feature of FGFR5 is that it does not contain an intracellular tyrosine kinase domain [9].

Analytical, diagnostic and therapeutic context of FGFRL1

FGFRL1 was expressed preferentially in skeletal tissues as demonstrated by Northern blotting and in situ hybridization [1].

References

Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues. Trueb, B., Zhuang, L., Taeschler, S., Wiedemann, M. J. Biol. Chem. (2003)
Signalling by the FGFR-like tyrosine kinase, Kringelchen, is essential for bud detachment in Hydra vulgaris. Sudhop, S., Coulier, F., Bieller, A., Vogt, A., Hotz, T., Hassel, M. Development (2004)
Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors. Wiedemann, M., Trueb, B. Genomics (2000)
Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells. Antoine, M., Wirz, W., Tag, C.G., Mavituna, M., Emans, N., Korff, T., Stoldt, V., Gressner, A.M., Kiefer, P. Growth Factors (2005)
Aberrant expression of FGFRL1, a novel FGF receptor, in ovarian tumors. Schild, C., Trueb, B. Int. J. Mol. Med. (2005)
Fish possess multiple copies of fgfrl1, the gene for a novel FGF receptor. Trueb, B., Neuhauss, S.C., Baertschi, S., Rieckmann, T., Schild, C., Taeschler, S. Biochim. Biophys. Acta (2005)
A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas(1). Kim, I., Moon, S., Yu, K., Kim, U., Koh, G.Y. Biochim. Biophys. Acta (2001)
Expression of FGFRL1, a novel fibroblast growth factor receptor, during embryonic development. Trueb, B., Taeschler, S. Int. J. Mol. Med. (2006)
Identification of a new fibroblast growth factor receptor, FGFR5. Sleeman, M., Fraser, J., McDonald, M., Yuan, S., White, D., Grandison, P., Kumble, K., Watson, J.D., Murison, J.G. Gene (2001)