Psychiatry related information on Rabep1

• Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease [1].

High impact information on Rabep1

• Western blot analysis of the mouse brain showed reduced levels of calpastatin and rabaptin-5 and higher amount of neuronatin in PKU compared to the wild type [2].
• Lipid rafts-associated molecules, such as GM1 ganglioside, were selectively included into macropinosomes, but Rab5 effector early endosome autoantigen (EEA1) and lysosomal glycoprotein LAMP-1 were excluded from macropinosomes containing B. abortus induced by swimming internalization [3].
• We report here the cloning of a novel neurite outgrowth factor, designated neurocrescin, from chick denervated skeletal muscle [4].
• A recombinant neurocrescin promoted neurite outgrowth from cultured neurons of spinal cord and telencephalon of chick embryo [4].
• Identification of a new alternative-splicing transcript of Rabaptin-5 interacting with protein kinase MAK-V [5].

Anatomical context of Rabep1

• Thus, neurocrescin appears to be a novel neurite outgrowth factor that is secreted in an activity-dependent fashion [4].

Analytical, diagnostic and therapeutic context of Rabep1

• Neurocrescin: a novel neurite-outgrowth factor secreted by muscle after denervation [4].

References