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POLE  -  polymerase (DNA directed), epsilon,...

Homo sapiens

Synonyms: CRCS12, DNA polymerase II subunit A, DNA polymerase epsilon catalytic subunit A, FILS, POLE1
 
 
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Disease relevance of POLE

 

Psychiatry related information on POLE

  • A significant decrease in social interaction with fellow crewmembers occurred at South Pole Station, Vostok Station, and Poland's Arctowski Station [4].
 

High impact information on POLE

  • Subretinal Posterior Pole Injury Induces Selective Proliferation of RPE Cells in the Periphery in In Vivo Studies in Pigs [5].
  • Structural organization and splice variants of the POLE1 gene encoding the catalytic subunit of human DNA polymerase epsilon [6].
  • Sequential sera collected from 16 of the 18 subjects wintering at South Pole during 1976 were tested by hemagglutination inhibition for antibody against parainfluenzavirus types 1 and 3 [7].
  • Anthropogenic iodine-129 in seawater along a transect from the Norwegian coastal current to the North Pole [8].
  • Variation in the concentrations of iodine-129 (129I, T1/2=15.7 Myr), a low-level radioactive component of nuclear fuel waste, is documented in surface waters and depth profiles collected during 2001 along a transect from the Norwegian Coastal Current to the North Pole [8].
 

Biological context of POLE

  • The NO2 concentrations increased when nearing to the South Pole, supporting the theory that atmospheric circulation converges in the polar regions [9].
  • The CELSS Antarctic Analog Project: an advanced life support testbed at the Amundsen-Scott South Pole Station, Antarctica [10].
  • Estimates of energy expenditure using both isotope-labelled (2H2(18)O) water and dietary intake/body composition changes were made during an attempt by two men (MS and RF) to walk to the North Pole [11].
 

Other interactions of POLE

  • Transventricular impedance was measured by injecting a subthreshold biphasic rectangular pulse of 600 micro A between poles 1 of the CS catheter and pole 1 of the RVA catheter and the voltage measured between CS pole 10 and RVA catheter pole 4 [12].
 

Analytical, diagnostic and therapeutic context of POLE

  • This would imply that, for South Pole conditions, halo polarimetry (or even photometry) is a more reliable method for crystal size determination than actual sampling [13].
  • Longitudinal studies of behavior and performance during a winter at the South Pole [14].
  • A high-resolution mapping and sampling study of the Gakkel ridge was accomplished during an international ice-breaker expedition to the high Arctic and North Pole in summer 2001 [15].
  • Today the ozone hole over the South Pole reaches about the size of Europe. This means for the physician to prescribe aerosol therapy completely free of CFCs, e.g. by DPIs and nebulizers or CFC-free pMDIs [16].
  • The World Wide Web server of the PBIL (Pôle Bioinformatique Lyonnais) provides on-line access to sequence databanks and to many tools of nucleic acid and protein sequence analyses [17].

References

  1. Persistent parainfluenza virus shedding during isolation at the South Pole. Muchmore, H.G., Parkinson, A.J., Humphries, J.E., Scott, E.N., McIntosh, D.A., Scott, L.V., Cooney, M.K., Miles, J.A. Nature (1981) [Pubmed]
  2. Recovery of Pseudoterranova decipiens (Anisakidae) larvae from codfish of the Antarctic Ocean. Chai, J.Y., Guk, S.M., Sung, J.J., Kim, H.C., Park, Y.M. Korean J. Parasitol. (1995) [Pubmed]
  3. Thermal changes observed before and after J.-L. Etienne's journey to the North Pole. Is central nervous system temperature preserved in hypothermia? Bittel, J.H., Livecchi-Gonnot, G.H., Hanniquet, A.M., Poulain, C., Etienne, J.L. European journal of applied physiology and occupational physiology. (1989) [Pubmed]
  4. Cross-cultural differences in psychosocial adaptation to isolated and confined environments. Palinkas, L.A., Johnson, J.C., Boster, J.S., Rakusa-Suszczewski, S., Klopov, V.P., Fu, X.Q., Sachdeva, U. Aviation, space, and environmental medicine. (2004) [Pubmed]
  5. Subretinal Posterior Pole Injury Induces Selective Proliferation of RPE Cells in the Periphery in In Vivo Studies in Pigs. Kiilgaard, J.F., Prause, J.U., Prause, M., Scherfig, E., Nissen, M.H., la Cour, M. Invest. Ophthalmol. Vis. Sci. (2007) [Pubmed]
  6. Structural organization and splice variants of the POLE1 gene encoding the catalytic subunit of human DNA polymerase epsilon. Huang, D., Pospiech, H., Kesti, T., Syväoja, J.E. Biochem. J. (1999) [Pubmed]
  7. Serologic evidence for parainfluenzavirus infection during isolation at South Pole Station, Antarctica. Parkinson, A.J., Muchmore, H.G., McConnell, T.A., Scott, L.V., Miles, J.A. Am. J. Epidemiol. (1980) [Pubmed]
  8. Anthropogenic iodine-129 in seawater along a transect from the Norwegian coastal current to the North Pole. Alfimov, V., Aldahan, A., Possnert, G., Winsor, P. Mar. Pollut. Bull. (2004) [Pubmed]
  9. Measurement of atmospheric NO2 concentrations in Antarctica with NO2 filter badge and tube. Matsuki, H., Yoshikawa, K., Yanagisawa, Y., Kasuga, H. Tokai J. Exp. Clin. Med. (2002) [Pubmed]
  10. The CELSS Antarctic Analog Project: an advanced life support testbed at the Amundsen-Scott South Pole Station, Antarctica. Straight, C.L., Bubenheim, D.L., Bates, M.E., Flynn, M.T. Life support & biosphere science : international journal of earth space. (1994) [Pubmed]
  11. Measurements of energy expenditure using isotope-labelled water (2H2(18)O) during an Arctic expedition. Stroud, M.A., Coward, W.A., Sawyer, M.B. European journal of applied physiology and occupational physiology. (1993) [Pubmed]
  12. Can transventricular intracardiac impedance measurement discriminate haemodynamically unstable ventricular arrhythmias in human? Kaye, G., Edgar, D., Mudawi, T., Lippert, M., Czygan, G. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2007) [Pubmed]
  13. Halo polarization profiles and sampled ice crystals: observations and interpretation. Können, G.P., Wessels, H.R., Tinbergen, J. Applied optics. (2003) [Pubmed]
  14. Longitudinal studies of behavior and performance during a winter at the South Pole. Palinkas, L.A., Johnson, J.C., Boster, J.S., Houseal, M. Aviation, space, and environmental medicine. (1998) [Pubmed]
  15. Magmatic and amagmatic seafloor generation at the ultraslow-spreading Gakkel ridge, Arctic Ocean. Michael, P.J., Langmuir, C.H., Dick, H.J., Snow, J.E., Goldstein, S.L., Graham, D.W., Lehnert, K., Kurras, G., Jokat, W., Mühe, R., Edmonds, H.N. Nature (2003) [Pubmed]
  16. Chlorofluorocarbon-free aerosol therapy in patients with pulmonary airflow obstruction. Matthys, H. Respiration; international review of thoracic diseases. (1996) [Pubmed]
  17. Integrated databanks access and sequence/structure analysis services at the PBIL. Perrière, G., Combet, C., Penel, S., Blanchet, C., Thioulouse, J., Geourjon, C., Grassot, J., Charavay, C., Gouy, M., Duret, L., Deléage, G. Nucleic Acids Res. (2003) [Pubmed]
 
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