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Gene Review

dof1  -  DNA-binding with one finger1

Zea mays

 
 
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Disease relevance of MNB1a

 

High impact information on MNB1a

  • The basic region of MNB1b exhibits homology to the high mobility group (HMG) box of the vertebrate HMG1 family, whereas MNB1a exhibits no homology to any known proteins [2].
  • Southern blot analysis of genomic DNA revealed that the cDNA for MNB1a is derived from a multigene family whose members have highly homologous N-terminal basic domain, whereas the gene for MNB1b exhibits only limited homology to a few other genes [2].
  • Mutations at cysteine residues eliminated the DNA-binding activity of MNB1a [1].
  • In this study, isolation of cDNAs from the gene family to which MNB1a belongs revealed a unique conserved domain, referred to herein as the Dof domain, that contains a novel cysteine-rich motif for a single putative zinc finger [1].

References

 
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