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Gene Review

SPIN2A  -  spindlin family, member 2A

Homo sapiens

Synonyms: DXF34, Protein DXF34, SPIN-2, SPIN-2A, SPIN2, ...
 
 
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Disease relevance of SPIN2A

  • A 2-Mb YAC contig encompassing three loci (DXF34, DXS14, and DXS390) that lie between Xp11.2 translocation breakpoints associated with incontinentia pigmenti type 1 [1].
 

High impact information on SPIN2A

  • In 32Dcl3 cells, expression of exogenous SPIN-2 provides 25% protection from apoptosis following growth factor withdrawal compared to controls which show approximately 1-2% survival [2].
  • Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression [2].
  • SPIN-2 overexpression slows cell growth rates and increases the percentage of cells in G(2)/M (32% vs control cells at 12%) [2].
  • This expansion of the cloned region around DXF34 and DXS390 will enable the isolation of additional conserved sequences that will help in understanding both the lesions underlying the pathogenesis of IP1 and the size and extent of the man-mouse homologous block defined by DXF34 [1].
  • The mapping of another probe that detects a novel sequence family (DXF34) close to the X chromosome centromere in both species suggests that a block of pericentromeric material is conserved between the X chromosomes of man and mouse [3].

References

  1. A 2-Mb YAC contig encompassing three loci (DXF34, DXS14, and DXS390) that lie between Xp11.2 translocation breakpoints associated with incontinentia pigmenti type 1. Reed, V., Rider, S., Maslen, G.L., Hatchwell, E., Blair, H.J., Uwechue, I.C., Craig, I.W., Laval, S.H., Monaco, A.P., Boyd, Y. Genomics (1994) [Pubmed]
  2. Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression. Fletcher, B.S., Dragstedt, C., Notterpek, L., Nolan, G.P. Leukemia (2002) [Pubmed]
  3. Novel sequences conserved on the human and mouse X chromosomes. Laval, S.H., Boyd, Y. Genomics (1993) [Pubmed]
 
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