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TOMM7  -  translocase of outer mitochondrial...

Homo sapiens

Synonyms: AD-014, Mitochondrial import receptor subunit TOM7 homolog, TOM7, TOMM07, Translocase of outer membrane 7 kDa subunit homolog
 
 
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High impact information on TOMM7

  • Tom7 functions in mitochondrial protein biogenesis by a new mechanism, segregation of a sorting component, leading to a differentiation of beta-barrel assembly [1].
  • Mitochondrial protein sorting: differentiation of beta-barrel assembly by Tom7-mediated segregation of Mdm10 [1].
  • Tom7 is imported into mitochondria in a nucleotide-independent manner and is anchored to the outer membrane with its C terminus facing the intermembrane space [2].
  • Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane [2].
  • Unlike studies in fungi, we found that human Tom7 assembles into an approximately 120-kDa import intermediate in HeLa cell mitochondria [2].
 

Analytical, diagnostic and therapeutic context of TOMM7

  • The cDNA encoding TOM7 (translocase of outer mitochondrial membrane subunit 7) like protein in wheat was cloned through RT-PCR, and its genomic DNA fragment was subsequently cloned [3].

References

  1. Mitochondrial protein sorting: differentiation of beta-barrel assembly by Tom7-mediated segregation of Mdm10. Meisinger, C., Wiedemann, N., Rissler, M., Strub, A., Milenkovic, D., Schönfisch, B., Müller, H., Kozjak, V., Pfanner, N. J. Biol. Chem. (2006) [Pubmed]
  2. Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane. Johnston, A.J., Hoogenraad, J., Dougan, D.A., Truscott, K.N., Yano, M., Mori, M., Hoogenraad, N.J., Ryan, M.T. J. Biol. Chem. (2002) [Pubmed]
  3. Cloning and characterization of TOM7-like gene in wheat. Zhang, Z.Z., Ma, Z.Q. Yi Chuan Xue Bao (2005) [Pubmed]
 
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