Disease relevance of POU3F3

• In silico expression analyses revealed that human WNT8B was expressed in embryoid body derived from embryonic stem (ES) cells, hepatocyte progenitors derived from ES cells, fetal brain, diffuse-type gastric cancer, colorectal cancer, prostate cancer, and ovarian fibrotheoma [1].
• BACKGROUND: Patients with a single episode of neurologic dysfunction and brain magnetic resonance imaging (MRI) scans suggestive of multiple sclerosis are at high risk for clinically definite multiple sclerosis, but the outcome for individual patients is unpredictable [2].
• Deposition of fibrillar amyloid beta-protein (Abeta) in the brain is a prominent pathological feature of Alzheimer disease and related disorders, including familial forms of cerebral amyloid angiopathy (CAA) [3].
• Outcomes; Neurocognitive Outcome and Serum Biomarkers in Inflicted versus Non-Inflicted Traumatic Brain Injury in Young Children [4].
• Images in clinical medicine. Brain herniation in toxoplasmosis [5].

Psychiatry related information on POU3F3

• Pten and the Brain: Sizing up Social Interaction [6].
• METHODS: Brain (15)O-water positron emission tomography was performed in 15 right-handed healthy volunteers during baseline and distal gastric distentions to 10 mm Hg, 20 mm Hg, threshold pain, and moderate pain [7].
• NIH Conference. Brain imaging: aging and dementia [8].
• CONCLUSION: Multiple factors that affect or are affected at the individual level by major depressive episodes in the course of bipolar disorder significantly interact in influencing brain cortical activity in specific areas [9].
• Although previous studies have implicated a diverse set of brain regions in reward-related decision making, it is not yet known which of these regions contain information that directly reflects a decision [10].

High impact information on POU3F3

• Mitochondrial aspartyl-tRNA synthetase deficiency causes leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation [11].
• Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation (LBSL) has recently been defined based on a highly characteristic constellation of abnormalities observed by magnetic resonance imaging and spectroscopy [11].
• Two studies, one in this issue of Cell and the other in Developmental Cell show that the cell-fate determinant Brain Tumor (Brat) suppresses self-renewal in one of the daughter cells that arise from the asymmetric division of a neural stem cell [12].
• BACKGROUND: Brain (B-type) natriuretic peptide is a neurohormone synthesized predominantly in ventricular myocardium [13].
• Neurobiology. Brain center linked to perfect pitch [14].

Chemical compound and disease context of POU3F3

• The database of the Brain Resuscitation Clinical Trial I, a multi-institutional study designed to evaluate the effect of thiopental sodium therapy on neurological outcome following brain ischemia, was used for a retrospective review of the effects of glucocorticoid treatment on neurological outcome after global brain ischemia [15].
• As in major depression, selective serotonin reuptake inhibitors targeting brain serotonin transporters are first-line treatments for bipolar depression [16].
• Phase II evaluation of temozolomide and 13-cis-retinoic acid for the treatment of recurrent and progressive malignant glioma: a North American Brain Tumor Consortium study [17].
• Dose escalation of carmustine in surgically implanted polymers in patients with recurrent malignant glioma: a New Approaches to Brain Tumor Therapy CNS Consortium trial [18].
• Phase I trial of tipifarnib in patients with recurrent malignant glioma taking enzyme-inducing antiepileptic drugs: a North American Brain Tumor Consortium Study [19].

Biological context of POU3F3

• Human class III POU genes, POU3F1 and POU3F3, map to chromosomes 1p34.1 and 3p14.2 [20].
• We have previously characterized binding sites for the NF-Y transcription factor (-71/-52) and Brn-2 POU-domain protein (-92/-71) in the neuronal promoter of the human aromatic L-amino acid decarboxylase gene [Mol. Brain Res. 56 (1998) 227] [21].
• Editorial: Brain infarction and blood pressure [22].
• Exploring brain connectivity: a new frontier in systems neuroscience. Functional Brain Connectivity, 4-6 April 2002, Dusseldorf, Germany [23].
• Phosphorylation of S783 is evident in many brain regions, and is increased dramatically after ischemic injury [24].

Anatomical context of POU3F3

• In addition, investigators have reported effective use of allogeneic adult pluripotent stem cells in acute ischemic injury models in the heart and brain, supporting the 'off the shelf' product concept for this cellular therapy [25].
• No significant pathomorphological changes were observed in liver, kidney, brain and gonads of F(2B) pups [26].
• In this study, we transplanted adult neural precursor cells (aNPCs) from the brain of adult transgenic mice into the spinal cords of adult Shiverer (shi/shi) mice, which lack compact CNS myelin [27].
• Re: Brain and other central nervous system cancers: recent trends in incidence and mortality [28].
• Brain areas in the frontal lobe have been implicated in behavioral flexibility and control [29].

Associations of POU3F3 with chemical compounds

• Antagonists were also identified of the related BRN1/DNA and BRN2/DNA transcription factor complexes indicating that a 1,4-disubstituted naphthalene may be a privileged scaffold for preparing screening libraries targeting this family of transcription factor complexes [30].
• Neither age, brain weight and pH, hemisphere, post-mortem interval, disease onset/duration, nor cumulative dose of fluphenazine affected S-adenosyl methionine content [31].
• Alanine, glycine, and proline repeats were present in the mammalian Brain-1 gene, whereas most of these repeats were absent in the nonmammalian homologue [32].
• Recommendations for the establishment of primary stroke centers. Brain Attack Coalition [33].
• Proceedings of the meeting will be published in Progress in Brain Research in 2005 [34].

Physical interactions of POU3F3

• Based on these conflicting observations, we sought to determine whether brain parenchymal factors that selectively interact with and modulate CAA mutant Abeta fibril assembly exist [3].
• In contrast, venlafaxine increased [123I]beta-CIT binding to DAT in the striatum (10.1%) after 5 days of administration of 150 mg/d. The displacement of [123I]beta-CIT from brain SERT and the increase in striatal [123I]beta-CIT binding to DAT appear similar to previous work with the SSRI citalopram (40 mg/d) [35].
• The transcription factor CREB (cyclic AMP response element binding protein) is implicated in diverse brain functions and represents a prospective target in gene therapy for human disorders [36].
• The discovery of glial NMDA receptors further indicates the complex nature of intercellular signaling mechanisms in the brain, which involve all types of neural cells, connected through diverse types of chemical and electrical synapses [37].
• METHODS: Brain samples from RE and complex partial epilepsy control patients were analyzed immunohistochemically [38].

Regulatory relationships of POU3F3

• Apolipoprotein-E (apoE) regulates brain lipid transport and specific neuronal functions and previous research, investigating non-neuronal cell types, identified an association between apoptosis and increased apoE expression [39].
• Expression of cellular adhesion molecule 'OPCML' is down-regulated in gliomas and other brain tumours [40].
• Northern hybridization revealed that EFCBP1 is specifically expressed in brain and its abundance varies in different brain regions [41].
• Understanding the mechanisms of leukocyte trafficking into the brain might provide insights into how to modulate pathologic immune responses or enhance host protective mechanisms in neuroinflammatory diseases such as multiple sclerosis [42].
• By contrast, in healthy children, possession of the risk allele was associated with different trajectories in gray matter only and was confined to frontotemporal regions, reflecting epistatic or other illness-specific effects mediating NRG1 influence on brain development in COS [43].

Other interactions of POU3F3

• Evidence for a wide extra-astrocytic distribution of S100B in human brain [44].
• HOXA1 is a member of the homeobox gene family and is involved in early brain development [45].
• HER4/ErbB4 is a receptor tyrosine kinase whose transcript undergoes alternative splicing in the brain [46].
• Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo [47].
• Estrogen-Induced Activation of Mammalian Target of Rapamycin Is Mediated via Tuberin and the Small GTPase Ras Homologue Enriched in Brain [48].

Analytical, diagnostic and therapeutic context of POU3F3

• BACKGROUND: Brain tumours rarely occur in survivors of childhood acute lymphoblastic leukaemia after cranial radiotherapy [49].
• Cardiopulmonary bypass in brain-dead organ donors. The Brain Death Study Group [50].
• MAIN OUTCOME MEASURES: Brain blood oxygen level-dependent functional magnetic resonance imaging using a 3.0-T scanner before and after treatment [9].
• Here, we used magnetoencephalography to measure time-dependent brain responses in human observers experiencing texture completion [51].
• Phase II study of first-line chemotherapy with temozolomide in recurrent oligodendroglial tumors: the European Organization for Research and Treatment of Cancer Brain Tumor Group Study 26971 [52].

References