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Gene Review

POU4F1  -  POU class 4 homeobox 1

Homo sapiens

Synonyms: BRN3A, Brain-3A, Brain-specific homeobox/POU domain protein 3A, Brn-3A, Homeobox/POU domain protein RDC-1, ...
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Disease relevance of POU4F1


High impact information on POU4F1


Anatomical context of POU4F1

  • We have refined the location of the Brn-3a genomic locus (POU4F1), using somatic cell hybrid analysis, to 13q21.1-->q22 [5].
  • A virtual screen of in-house compounds was then performed and positive hits screened for their ability to invoke a Ca2+ response in a recombinant RDC1 HEK293 cell line, as measured by FLIPR [2].
  • Transcripts of RDC1 were found in astrocytes, heart, kidney, the mesangial tumor line MES-13, spleen, and neutrophils by means of northern blot [6].


  1. A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system. Collum, R.G., Fisher, P.E., Datta, M., Mellis, S., Thiele, C., Huebner, K., Croce, C.M., Israel, M.A., Theil, T., Moroy, T. Nucleic Acids Res. (1992) [Pubmed]
  2. The orphan G-protein coupled receptor RDC1: evidence for a role in chondrocyte hypertrophy and articular cartilage matrix turnover. Jones, S.W., Brockbank, S.M., Mobbs, M.L., Le Good, N.J., Soma-Haddrick, S., Heuze, A.J., Langham, C.J., Timms, D., Newham, P., Needham, M.R. Osteoarthr. Cartil. (2006) [Pubmed]
  3. Molecular cytogenetic mapping of recurrent chromosomal breakpoints in tenosynovial giant cell tumors. Nilsson, M., Höglund, M., Panagopoulos, I., Sciot, R., Dal Cin, P., Debiec-Rychter, M., Mertens, F., Mandahl, N. Virchows Arch. (2002) [Pubmed]
  4. Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells. Bhargava, A.K., Li, Z., Weissman, S.M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  5. The Brn-3a transcription factor gene (POU4F1) maps close to the locus for the variant late infantile form of neuronal ceroid-lipofuscinosis. Still, I.H., Cowell, J. Cytogenet. Cell Genet. (1996) [Pubmed]
  6. Cloning and chromosomal mapping of an orphan chemokine receptor: mouse RDC1. Heesen, M., Berman, M.A., Charest, A., Housman, D., Gerard, C., Dorf, M.E. Immunogenetics (1998) [Pubmed]
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