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Gene Review

sdc2  -  syndecan 2

Xenopus (Silurana) tropicalis

 
 
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High impact information on sdc2

  • These results demonstrate that PKCgamma regulates the cytoplasmic phosphorylation of syndecan-2 and, consequently, syndecan-2-mediated inside-out signaling to adjacent cells [1].
  • The transmembrane proteoglycan syndecan-2 cell nonautonomously regulates left-right (LR) development in migrating mesoderm by an unknown mechanism, leading to LR asymmetric gene expression and LR orientation of the heart and gut [1].
  • A partial syndecan-2 sequence (147 bp) was obtained from chicken embryonic fibroblast poly(A)+ RNA by reverse transcription-PCR [2].
  • Chicken Syndecan-2 (cSyndecan-2) is the homologue of Xenopus Syndecan-2, a member of the heparan sulfate proteoglycan family with an important role in left-right patterning in frog embryos [3].
  • Ectodermal syndecan-2 mediates left-right axis formation in migrating mesoderm as a cell-nonautonomous Vg1 cofactor [4].
 

Biological context of sdc2

  • Here, we demonstrate that protein kinase C gamma (PKCgamma) mediates phosphorylation of the cytoplasmic domain of syndecan-2 in right, but not left, animal cap ectodermal cells [1].
 

Anatomical context of sdc2

  • We report here that syndecan-2 functions in the ectoderm to mediate cardiac and visceral situs, upstream of known asymmetrically expressed genes but independently of its ability to mediate fibronectin fibrillogenesis [4].
 

Analytical, diagnostic and therapeutic context of sdc2

  • Sequence analysis of randomly selected clones demonstrated expression of both identified (calmodulin, SNARE protein, syndecan-2) and unidentified genes, and confirmed synthesis of full length transcripts [5].

References

  1. PKCgamma regulates syndecan-2 inside-out signaling during xenopus left-right development. Kramer, K.L., Barnette, J.E., Yost, H.J. Cell (2002) [Pubmed]
  2. Molecular characterization of chicken syndecan-2 proteoglycan. Chen, L., Couchman, J.R., Smith, J., Woods, A. Biochem. J. (2002) [Pubmed]
  3. Asymmetric expression of Syndecan-2 in early chick embryogenesis. Fukumoto, T., Levin, M. Gene Expr. Patterns (2005) [Pubmed]
  4. Ectodermal syndecan-2 mediates left-right axis formation in migrating mesoderm as a cell-nonautonomous Vg1 cofactor. Kramer, K.L., Yost, H.J. Dev. Cell (2002) [Pubmed]
  5. Identification of genes expressed in the Xenopus inner ear. Serrano, E.E., Trujillo-Provencio, C., Sultemeier, D.R., Bullock, W.M., Quick, Q.A. Cell. Mol. Biol. (Noisy-le-grand) (2001) [Pubmed]
 
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